translation initiation factor 3
The eukaryotic translation initiation factor 3 subunit L protein interacts with FlavivirusNS5 and may modulate yellow fever virus replication
... eukaryotic translation initiation factor 3 (eIF3L) is one of the subunits of the mammalian translation initiation factor eIF3 ...eIF3 factor plays a central role in ...
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Eukaryotic translation initiation factor 3 subunit G (EI F3G) resensitized HC T116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1
... mortality factor for patients due to no available therapeutic ...eukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized 5-Fu-resistant human CRC cells (HCT116/5-Fu) ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia ...
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PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes
... a factor greater than three) revealed that ~58% also fell into three categories: mRNAs encoding proteins involved in nucleic acid metabolism ...vs. factor of enrichment of the 106 mRNAs most enriched in the ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... indeed, as a scaffold protein bridging together CB, eIF3 and mTOR, and that CB, maybe through its GEF activ- ity, is the protein responsible for activation of mTOR signaling. One possibility is that CB may promote gua- ...
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Activation of AP-1-Dependent Transcription by a Truncated Translation Initiation Factor
... eukaryotic translation initiation factor 3 (eIF3) that has also been reported to interact with subunits of the proteasome and the COP9 ...
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Experimental Analysis of Mimivirus Translation Initiation Factor 4a Reveals Its Importance in Viral Protein Translation during Infection of Acanthamoeba polyphaga
... (1, 3, 17). The discovery of protein-coding genes belonging to translation in its genome is highly intriguing as their biological importance remains unknown (18, ...in translation, along with aa-RSs ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... eukaryotic translation initiation factor 2, which is a key protein that catalyzes the initiation of protein ...the translation initiation factor family, plays a key role ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... Figure 3.—Suppression of the lethal effect associated with deletion of the five eIF2B sub- unit genes. Low-copy (L.C.; pSB32) or high-copy (H.C.; YEp13) LEU2 plasmids indi- cated to the left of the figure were ...
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Cell-Type-Specific Growth Restriction of Vesicular Stomatitis Virus polR Mutants Is Linked to Defective Viral Polymerase Function
... ⬃ 3-fold less in hamster BHK ...eukaryotic translation initiation factor 2 (eIF-2 ␣ ) was enhanced ⬃ 3-fold in polR versus wild-type virus-infected L-929 cells, but neither inhibition ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... were counted at different times by trypan blue exclusion after trypsination. Mutagenesis and expression of recombinant NSP3. Expression of NSP3 fused to a track of 6 histidine residues in Escherichia coli using the T7 ...
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Translational Control of the Abundance of Cytoplasmic Poly(A) Binding Protein in Human Cytomegalovirus-Infected Cells
... and 3 ⬘ polyadenylate tails like their host cell counterparts and are primarily translated by a cap-dependent ...tion initiation factor eIF4F represents a key step regulating translation ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... (Fig. 3, lanes 1 to ...the 3 * part of the ...and 3 but not with those carrying a deletion of stem-loop ...the 3 9 -terminal half of stem-loop 5 or insertion of a se- quence of six nucleotides ...
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Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... Figure 4.—Localization of wild-type eIF5A. (A) Endoge- nous eIF5A localization in fixed cells. Wild-type cells (FY23) Figure 2.—Lesions in tif51A temperature-sensitive alleles. were grown at 25⬚ to midlog phase and fixed ...
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mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation Factor
... Although Vhs does not discriminate between mRNAs, it does exhibit two important kinds of selectivity. First, it exhibits a strong preference for mRNAs, as opposed to non-mRNAs. This is true in vivo (27, 28) as well as in ...
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The IE180 Protein of Pseudorabies Virus Suppresses Phosphorylation of Translation Initiation Factor eIF2α
... PRV interferes with eIF2 ␣ phosphorylation. We previously de- scribed that PRV is able to counteract IFN-mediated phosphory- lation of eIF2 ␣ in 50B11 neuronal cells (24). Here, we used thap- sigargin to induce ...
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Two Genes Become One: The Genes Encoding Heterochromatin Protein SU(VAR)3-9 and Translation Initiation Factor Subunit eIF-2γ Are Joined to a Dicistronic Unit in Holometabolic Insects
... In contrast to already known cases of polycistronic clusters (Alfonso et al. 1994; Zhang et al. 1999) where the shared exons are noncoding, the fused Su(var)3-9 and eIF-2␥ genes are unique in sharing N-terminally ...
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The Biological Roles of Translation Initiation Factor 3b
... growth factor (TGF) 5’ untranslated regions (UTRs) and eIF3b in an RNA-independent manner can promote the translation of TGF-1, 2, and 3 in NIH-3T3 cells ...gene) 3’UTR, which regulates the ...
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Interaction of Translation Initiation Factor eIF4B with the Poliovirus Internal Ribosome Entry Site
... their 3⬘ borders (8, 42, ...actual initiation codon further downstream is reached by ribosomal scanning (20, 22, 25, ...of initiation factors. In addition to the standard initiation factors, ...
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Regulation of Translation by Ribosome Shunting through Phosphotyrosine-Dependent Coupling of Adenovirus Protein 100k to Viral mRNAs
... Tyrosine phosphorylation of 100k protein promotes its pref- erential late viral interaction with tripartite leader mRNAs. We recently showed that 100k has two distinct RNA-binding motifs (25). A nonspecific RNA-binding ...
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