translation initiation factors 3
Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution.
... (Fig. 3, compare mutants pND11-4 and ...(1, 3, 12, 38). Within any of the energy levels, differences in translation efficiency have been observed ...cell factors has been recently documented ...
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VPg of murine norovirus binds translation initiation factors in infected cells
... MNV-1 VPg was amplified from pSPORT-T7-MNV-1 (gift from H. Virgin, Washington University School of Medi- cine) using the primers MNV-VPg/BamHI(+) 5'-cgcggatc- cggaaagaagggcaagaac-3' and MNV-VPg/XhoI(-) 5'- ...
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PubMedCentral-PMC4848592.pdf
... the translation “start” codon ...a translation start site, which almost always consists of an AUG methionine codon in a favorable sequence context ...eIF5 initiation factors position the tRNA ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... Translation initiation in eukaryotes requires the parti- cipation of several eukaryotic initiation factors (eIFs), and the eIF3 is the largest and most complex of the eIFs, consisting of 13 ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... of translation of mRNAs encoding several cell cycle-related proteins, including cyclin D1, are increased in cells that overexpress eIF4E, and eIF4E overexpression stimulates cells to enter the cycle and/or un- ...
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Foot-and-Mouth Disease Virus 3C Protease Induces Cleavage of Translation Initiation Factors eIF4A and eIF4G within Infected Cells
... about 3 h postinfection in these ...of translation initiation factors was assessed by immunoblotting cell extracts with a panel of specific antibod- ...this initiation factor was also ...
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Translation Initiation Factor eIF4B Interacts with a Picornavirus Internal Ribosome Entry Site in both 48S and 80S Initiation Complexes Independently of Initiator AUG Location
... other initiation factors) to the IRES is the small ribosomal subunit able to enter the IRES ...of initiation com- plexes with the FMDV IRES appears to be a rather slow ...
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Impaired Binding of Standard Initiation Factors Mediates Poliovirus Translation Attenuation
... all initiation factors that are involved in formation of initiation complexes with the EMCV IRES also act on the poliovirus ...subunits, initiation factors, and possibly other cellular ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... a 3⬘ terminal poly(A) ...the 3⬘ poly(A) and the eukaryotic initiation factor eIF4G (14, 23, ...first initiation codon ...the translation of the mRNA by allowing rapid reinitiation of ...
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Targeting trypanosomatid translation factor interactions
... Trypanosomatids have multiple isoforms for some of its translation initiation factors ( e.g. it has 6 eIF4E, 5 eIF4G and 3 PABP isoforms). The existence of such a high number of isoforms is ...
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Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
... Little is known about the mechanisms by which the expression of EIF5A1 gene is regulated, but it was docu- mented that KRas 12th/13th codon mutated lung adeno- carcinoma has an increased eIF5A1 protein level [20]. What ...
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The Maize macrohairless1 Locus Specifically Promotes Leaf Blade Macrohair Initiation and Responds to Factors Regulating Leaf Identity
... macrohair initiation complex does exist in their greatest effect on promoting MH initiation in gl15 maize, we believe mhl1 would be most likely to represent mutant leaves, where mhl1 would be stimulated by ...
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Expression of p27Kip1, A Cell Cycle Repressor Protein with Dual Roles for Both Cancer Prevention and Promotion, Is Regulated Primarily at the Level of Unusual p27Kip1 mRNA—A Short Concept Proposal
... At this point, Dr. Albert Einstein’s “visualized thought experiments (German: Gedanken experiment)” will be used as a fundamental tool for understanding how anti-cancer agents modify the primary structure of the ...
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Genome-wide microRNA changes in human intracranial aneurysms
... protein translation machinery, including various eukaryotic translation initiation factors and ribosomal proteins, and this finding was highly correlated with our previous transcriptome data ...
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Translation initiation at a downstream AUG occurs with increased efficiency when the upstream AUG is located very close to the 5' cap.
... To determine whether the short length of the untranslated leader of this mRNA affects the efficiency of translation initiation at the LP1 initiation signal, monkey cells were transfected[r] ...
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The Biological Roles of Translation Initiation Factor 3b
... essential for rigorous AUG recognition [9,21,22]. Similarly, PRT1, a homolog of eIF3b in yeast, binds TIF32 (eIF3a), TIF35 (eIF3g), TIF34 (eIF3i), HCR1 (eIF3j), and Pci8 (eIF3e), which highlight the conserved nature of ...
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Loss of Ypk1 Function Causes Rapamycin Sensitivity, Inhibition of Translation Initiation and Synthetic Lethality in 14-3-3-Deficient Yeast
... disrupted translation, at least in part by causing depletion of eIF4G, a central adaptor protein required for cap-dependent mRNA translation ...translation initiation. These results suggest ...
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Genomic RNA of mengovirus. VI. Translation of its two cistrons in lysates of interferon-treated cells.
... The sequences of mengovirus RNA recognized by ribosomes of interferon-treated cells at initiation of translation were compared with those present in initiation complexes formed by riboso[r] ...
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Two Genes Become One: The Genes Encoding Heterochromatin Protein SU(VAR)3-9 and Translation Initiation Factor Subunit eIF-2γ Are Joined to a Dicistronic Unit in Holometabolic Insects
... In contrast to already known cases of polycistronic clusters (Alfonso et al. 1994; Zhang et al. 1999) where the shared exons are noncoding, the fused Su(var)3-9 and eIF-2␥ genes are unique in sharing N-terminally ...
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High expression of eIF3d is associated with poor prognosis in patients with gastric cancer
... A polyclonal antibody against eIF3d (ab155419; Abcam, Cambridge, MA, USA) was used in this study. Specimens were sectioned into 3- to 4-μm slices. After routine xylene dewaxing and gradient ethanol hydration, the ...
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