Transmission-Blocking
Methylene blue induced morphological deformations in Plasmodium falciparum gametocytes: implications for transmission blocking
... interrupt transmission. Primaquine is recommended as a transmission blocking drug for its effect on mature gametocytes but is not extensively utilized because of associated safety concerns among ...
9
The biology of sexual development of Plasmodium: the design and implementation of transmission blocking strategies
... a transmission-blocking vaccine (TBV), current active transmission reduction approaches rely on ...on transmission may be over-estimated because despite reducing gametocyte carriage [41] the ...
11
Plasmodium P25 and P28 Surface Proteins: Potential Transmission-Blocking Vaccines
... Several transmission-blocking vaccine formulations are be- ing developed using Plasmodium vivax and ...with transmission-blocking activity ...significant transmission-blocking ...
6
Asymptomatic Plasmodium vivax parasitaemia in the low transmission setting: the role for a population based transmission blocking vaccine for malaria elimination
... ongoing transmission through relapsed infections and asymptomatic infections, especially as chloroquine- resistant ...reduce transmission from both latently and subclinically low- level parasitaemic ...
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Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission blocking vaccine candidates
... including transmission from humans to mosquitoes [3]. Such transmission-blocking vaccines (TBVs) would not block disease in the vaccine recipients directly but rather would reduce the prevalence of ...
12
A discovery and development roadmap for new endectocidal transmission blocking agents in malaria
... for transmission-blocking vaccines [64, ...to transmission-blocking vac- cines [66, 67], with the most advanced candidate being in clinical testing ...
15
Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds
... The impact of Ver-EtOH on An. stephensi blood feeding was assessed to evaluate whether a reduction in mosquito infection in the in vivo transmission blocking experi- ment might be the result of decreased ...
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A controlled human malaria infection model enabling evaluation of transmission blocking interventions
... into transmission-blocking interventions (TBIs) has accelerated in the last decade (2, ...vivo transmission- blocking efficacy has yet to be determined, making it challenging for researchers ...
13
Arbovirosis and potential transmission blocking vaccines
... Designing vaccines that prevent the pathogen from completing its life-cycle in the vector is one approach to halting transmission to humans [45]. Such vaccine alterna- tives have received the name of ...
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Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates in Anopheles coluzzii mosquitoes
... Approximately 8 mL of gametocytaemic blood was collected from each selected child by venous puncture using heparinized tubes. Care was taken to keep the blood tubes constantly at 37°C to avoid gametocyte acti- vation ...
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<p>In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds</p>
... on transmission-blocking drugs, and TPP 1, that de fi nes drug ...interesting transmission-blocking pro fi le, given by their capacity to interfere with various transmissible stages, in the ...
15
Modelling the benefits of long acting or transmission blocking drugs for reducing Plasmodium falciparum transmission by case management or by mass treatment
... to transmission by treated versus untreated infected people ...to transmission of treated people is dwarfed by the relatively much longer tail of infectivity in untreated ...to transmission would be ...
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N-Terminal Prodomain of Pfs230 Synthesized Using a Cell-Free System Is Sufficient To Induce Complement-Dependent Malaria Transmission-Blocking Activity
... The monoclonal antibodies (MAbs) recognizing the CM do- main of Pfs230 potently block the infectivity of the P. falcipa- rum parasites to mosquitoes (26, 28, 29, 37). Several regions of Pfs230 have been expressed as ...
8
Transmission blocking strategies: the roadmap from laboratory bench to the community
... of transmission-blocking ...a transmission blocking vaccine, and drugs are being currently screened for gametocytocidal activity, and also some new and less conventional approaches are drawing ...
13
A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission blocking interventions
... multiple transmission-blocking interventions (TBIs) currently under development that aim to reduce transmission by inhibiting the development of oocysts in the mosquito midgut or by targeting sexual, ...
10
Cloning, expression and transmission blocking activity of anti PvWARP, malaria vaccine candidate, in Anopheles stephensi mysorensis
... Female An. stephensi mosquitoes were fed on mem- brane feeders (constructed from aquarium hitter, beaker and parafilm) containing 200 μl of P. vivax-infected blood plus 70 μl of antisera and normal human sera (donor ...
7
Transmission blocking activity of antibodies to Plasmodium falciparum GLURP 10C chimeric protein formulated in different adjuvants
... malaria transmission through use of insecticides and/or bed nets have resulted in only limited success ...mission blocking malaria vaccines (TBMV) which induce antibodies that target the sexual stages of ...
9
Prevention of Babesia canis in dogs: efficacy of a fixed combination of permethrin and fipronil (Effitix®) using an experimental transmission blocking model with infected Dermacentor reticulatus ticks
... block transmission of ...prevented transmission of mature Babesia sporozoites into the treated dogs, whereas they were readily transmitted to the untreated control ...the transmission of ...
10
A novel combination of fipronil and permethrin (Frontline Tri Act®/Frontect®) reduces risk of transmission of Babesia canis by Dermacentor reticulatus and of Ehrlichia canis by Rhipicephalus sanguineus ticks to dogs
... Both transmission blocking models were initially used to determine the level of transmission blocking of ...canis blocking model; one study addressed the preventive capacity of a ...
10
Sex and death : the effects of innate immune factors on the sexual reproduction of malaria parasites
... Currently, two complementary evolutionary theories predict how and why parasites should adjust their investment into male and female gametocytes to maximise fertilization success. These theories – Fertility Insurance and ...
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