TRPM2 channel
The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia
... (TRPM2) channel has emerged as a molecular mechanism conferring cells with the ability to sense oxidative stress/ ROS and mediating oxidative damage (Hara et ...multiple TRPM2-mediated cellular and ...
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TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies
... elevated TRPM2 mRNA expression in rat brains at 1 and 4 weeks after transient middle cerebral artery occlusion (MCAO), a widely-used rodent model of ischemic stroke (Fonfria et ...the TRPM2 channel, ...
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TRPM2 channel: A novel therapeutic target alleviating ischemia-reperfusion, chronic cerebral hypo-perfusion and neonatal hypoxic-ischemic brain damage
... the TRPM2 expression using lentivirus expressing TRPM2‐specific shRNA, or by genetically deleting the TRPM2 ...the TRPM2 channel in mediating ischaemia‐reperfusion brain ...
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Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
... The TRPM2 channel is expressed in both excitable and non-excitable cells ...the TRPM2 channel as a common mechanism mediating cell death after exposure to high levels of ROS or diverse ...
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TRPM2 channel-mediated ROS-sensitive Ca2+ signaling mechanisms in immune cells
... of TRPM2 channels in the CXCL2 production by immune cells in responses to infection and there were significant discrepancies in these studies using different cell preparations and infection ...and TRPM2-KO ...
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Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
... TTX. TRPM2 currents were generated with either repeated NMDAR activation or voltage ...the TRPM2 current stabilized, or after 10 minutes of recording, calcium free solution was applied (total divalent ...
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TRPM2 channel deficiency prevents delayed cytosolic Zn²⁺ accumulation and CA1 pyramidal neuronal death after transient global ischemia
... and TRPM2-KO mice. The survival rate of WT and TRPM2-KO mice was examined over a period of 72 h after being subjected to bilateral common carotid artery occlusion (BCCAO) followed by reperfusion, an in vivo ...
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A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species‐induced delayed cell death
... the TRPM2 channel is localized to the mitochondria and required for mitochondrial Zn 2+ ...TRPC3 channel is located in the mitochondria and plays an important role in mediating mitochondrial Ca 2+ ...
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<p>Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation</p>
... 9 TRPM2, the second member of this subfamily to be cloned, is a 1503-amino acid channel permeable to Ca 2+ , Na + , and K + ...of TRPM2 channel is oxidative stress. 11 TRPM2 knockdown ...
9
Inactivation of TRPM2 channels by extracellular divalent copper
... The TRPM2 channel belongs to the melastatin subfamily of the mammalian transient receptor potential (TRP) channels, which share several conserved domains with other TRPM channels, such as the TRPM homology ...
9
TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice
... TRPM2-deficient mice are more resistant to chronic experimental colitis due to defective chemokine (C-X-C motif ) ligand 2 (CXCL2) production by monocytes and reduced neutrophil infiltration [9]. Yet, a recent ...
8
Ionic signalling and mitochondrial dynamics
... The first step in the signalling pathway was a rise in intracellular ROS by the diabetic stress. By stimulating the TRPM2 channel, ROS increased the cytosolic Ca 2+ . Rise in Ca 2+ triggered lysosomal ...
7
Regulation of TRPM2 channels by Fyn kinase
... recordings. TRPM2 currents were isolated by exploiting distinctive channel activation and inactivation ...Peak TRPM2 current amplitudes were measured in cells treated with constitutively active ...
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Nitration of TRPM2 as a Molecular Switch Induces Autophagy during Brain Pericyte Injury
... pericyte TRPM2 channel during ZnO-NP-induced neurovascular ...the TRPM2 KO mice coincided with reduced pericyte injury in brain ...that TRPM2-dependent autophagy plays a crucial role in ...
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TRPM2 in the Central Nervous System: Physiological Role and Critical Regulatory Pathways
... cation channel which is permeable to ...for TRPM2 in neurons is ...regulating TRPM2 channel function requires further ...that TRPM2 is required for NMDAR-dependent ...of TRPM2. ...
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Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses
... in TRPM2 -/- slices results from enhanced phosphorylation and inactivation of ...in TRPM2 -/- slices and effectively rescued LTD induction by repetitive low-frequency ...of TRPM2 function by ...
9
Integrated chronological control on an archaeologically significant Pleistocene river terrace sequence: the Thames Medway, eastern Essex, England
... HMR’s research in eastern Essex was initially funded by a NERC studentship. The Medway Valley Palaeolithic Project was funded by English Heritage under the Aggregates Levy Sustainability Fund (Project 3836). In addition ...
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The role of individual, product and channel characteristics in brand switching behaviour
... the channel, a number of issues attract particular ...a channel context, even though there have been previous attempts to compare the three channels according to their ability to provide particular benefits ...
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Based on Premium Channels Package Optimum Combination of 0 1 Programming Model Design
... join channel j, get the current optimal combination packages, get the corresponding creating profit index value sum r i ", the A (j + 1, Y + 1) is the dynamic clock of this ...
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Predicting and Repurposing of Drug and Drug Like Compounds for Inhibition of the Covid-19 and Its Cytokine Storm by Computational Methods
... human TRPM2, is a dangerous condition for human and its body organ such as kidney, heart, and ...human TRPM2 that can initiate of the viral cell cycle infection and human cytokine storm ...with TRPM2 ...
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