Trypanosoma brucei rhodesiense
Loop-mediated isothermal amplification (LAMP) method for rapid detection of Trypanosoma brucei rhodesiense
... of Trypanosoma brucei rhodesiense, the cause of the acute form of African sleeping sickness, and used to detect parasite DNA from processed and heat-treated infected blood ...b. rhodesiense ...
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Evaluation of the TbgI2 and TbgI17 Tandem Repeat Antigens as Potential Antigens for the Diagnosis of Trypanosoma brucei rhodesiense
... genus Trypanosoma which is transmitted to hu- mans through the bite of a tsetse fly [1] ...by Trypanosoma brucei gambiense ( Tbg ), pre- dominantly found in the Central and West Africa and the acute ...
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Field Evaluation of LED Fluorescence Microscopy for Demonstration of Trypanosoma brucei rhodesiense in Patient Blood
... of Trypanosoma brucei rhodesiense human African trypanosomi- asis requires demonstration of parasites in body fluids by ...b. rhodesiense human African try- ...
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Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania
... Most reported rhodesiense HAT cases have been from the Serengeti National Park in Tanzania, which is in direct vicinity to Masai Mara of Kenya [7, 11–14]. This patient confirmed she was bitten by a tsetse fly in ...
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New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients
... The markers investigated in the present study were combined into panels in order to increase their accuracy in stage determination. The utility of this approach to achieve a better diagnostic accuracy has already been ...
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Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post conflict Uganda
... Interviews, market records and direct observations In 2008 a questionnaire was carried out with the District Veterinary Officers (DVO) from 13 districts in the northern and eastern region (endemic for T. b. ...
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Relationship between Trypanosoma brucei rhodesiense genetic diversity and clinical spectrum among sleeping sickness patients in Uganda
... In previous studies, a link between clinical diversity and parasite genetic diversity was proposed [9]. We investi- gated this possibility using our data set. However, we did not observe any significant associations ...
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Population genetic structure and temporal stability among Trypanosoma brucei rhodesiense isolates in Uganda
... Microsatellite markers in this study were valuable in assessing the genetic polymorphism among T. b. rhode- siense isolates. Results of this study have shown that iso- lates in Kaberamaido-Dokolo-Amolatar HAT focus have ...
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The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness
... b. rhodesiense HAT as this relies on the detection of trypanosomes on blood ...b. rhodesiense HAT diagnosis as compared to ...b. rhodesiense infections is through direct microscopic observation of ...
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A comparative evaluation of PCR based methods for species specific determination of African animal trypanosomes in Ugandan cattle
... (Trypanosoma brucei bru- cei, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense, Trypanosoma evansi and Trypanosoma equi- perdum), the most common ...
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Invivo Anti Trypanosomal Activity of Aqueous Extractof Azadirachta indica Leaves on Trypanosoma brucei brucei Infected Mice
... Azadirachta indica (A. indica) also known as Neem. Neemtree, and Indian Lilac are trees in the mahogany family Meliaceae. It is one of two species in the genus Azadirachta and it is a medicinal plant used in traditional ...
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Sugar Nucleotide Pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major
... 11. Berriman, M., E. Ghedin, C. Hertz-Fowler, G. Blandin, H. Renauld, D. C. Bartholomeu, N. J. Lennard, E. Caler, N. E. Hamlin, B. Haas, U. Bohme, L. Hannick, M. A. Aslett, J. Shallom, L. Marcello, L. Hou, B. Wickstead, ...
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Multiple Triclosan Targets in Trypanosoma brucei
... T. brucei enoyl-ACP reductase to triclosan is that it is structurally different from the conventional type II enoyl-ACP reductase enzyme, ...T. brucei database revealed no homolog to the bacterial FabI, ...
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Mitochondrial DNA Ligases of Trypanosoma brucei
... of Trypanosoma brucei, termed kinetoplast DNA or kDNA, consists of thousands of minicircles and a small number of maxicircles catenated into a single network organized as a nucleoprotein disk at the base of ...
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Molecular epidemiology of African sleeping sickness
... Keywords: African trypanosomiasis; Trypanosoma brucei; sleeping sickness; molecular.. epidemiology; epidemics; microsatellites; genetics; population structure..[r] ...
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Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling
... T. brucei and in the culture medium are Na + and K + ...T. brucei are low- Na + and high-K + cells [22], only a salinomycin-mediated transport of Na + from the exterior to the interior could explain the ...
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Anti-trypanosomal evaluation of Ximenia americana root bark and chromatographic-mass spectrometric profile
... Le et al. [17]. The flavonol has been established to have high radical scavenging capacity, thus anti-trypanosomal activity of X. americana root bark may be attributed possibly to antioxidant activity. Moreover, Maria et ...
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Rab23 is a flagellar protein in Trypanosoma brucei
... Genomes were chosen for sampling based on three main criteria: i) proposed position in the evolutionary tree of eukaryotes [21] ensuring adequate representation of major supergroups, ii) completeness of the sequenced ...
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An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics
... In conjunction with our commercial partner, MGB Biopharma, we have had great success in developing our MGBs as antibacterials [18] and, crucially, structural features of these MGBs are quite distinct from the diamidines. ...
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INVESTIGATION OF LIVESTOCK FOR PRESENCE OF TRYPANOSOMA BRUCEI GAMBIENSE IN TAFA LOCAL GOVERNMENT AREA OF NIGER STATE, NIGERIA
... Blood samples from a total of 460 animals made up of 177 white Fulani/Zebu cattle, 209 Yankasa sheep, 61 red Sokoto goats, 12 local dogs and 1 monkey were examined individually for the presence of pathogenic trypanosomes ...
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