TTF-1, thyroid transcription factor-1
Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas
... In 2000, Perou and co-workers indentified five mo- lecular subgroups of breast cancers (luminal A, luminal B, normal breast-like, Her2 positive or basal-like) by use of cDNA microarray and un-supervised cluster analysis ...
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Original Article Associations of deregulation of mir-365 and its target mRNA TTF-1 and survival in patients with NSCLC
... while TTF-1 was increased, it was showed that mir- 365 expression could downregulate TTF-1 [13, ...patients. Thyroid transcription factor 1 (TTF-1), ...
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Comparison of napsin a versus thyroid transcription factor 1 in the typing of lung carcinoma
... The NSCLC that lacked these specific histological features were classified under waste basket category of Large cell carcinoma. Distinguishing small cell carcinoma from Non small cell carcinoma was important for planning ...
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Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature
... The initial investigations of the biopsy gave suspicion of metastasis from lung cancer because of the positive TTF- 1 reaction. Previous studies have shown that lung cancer, malignant melanoma and lymphoma ...
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Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma
... Results: A 71-year-old man presented with a slowly growing 5-cm mass on the left side of the neck for approximately two months. The cut surface of the neoplasm was brown and black. Melanin was found in the cytoplasm of ...
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... and thyroid transcription factor-1 (TTF-1) Immunohistochemical profile of a carcino- ma is known to be useful aid in ascertaining the site of origin of an ...are ...
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Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report
... approximately 1% of endo- metrial carcinomas, but appear to be aggressive in na- ture [3, ...for thyroid transcription factor 1 (TTF-1), GATA binding protein-3 (GATA-3), ...
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Thyroid transcription factor-1 expression is significantly associated with mutations in exon 21 of the epidermal growth factor receptor gene in Chinese patients with lung adenocarcinoma
... and/or TTF-1 expression has not been clearly ...or TTF-1 expression (P= ...and TTF-1 expression in patients with disease stages III–IV disease (P= ...and TTF-1( + ...
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Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer
... of TTF-1 is helpful to distinguish primary lung cancer from other non- pulmonary ...While TTF-1-expression was found to be frequent in adenocarcinoma and small cell lung cancer, it appears to ...
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Congenital human thyroglobulin defect due to low expression of the thyroid specific transcription factor TTF 1
... are thyroid-specific transcription factors, from homeo and paired box genes, respectively, that are responsible for thyroid development and for thyroglobulin and thyroperoxidase gene ...However, ...
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The role of osmotic stress transcription factor 1 in fishes
... stress transcription factor 1 (Ostf1) is one of these factors and has been investigated since its discovery in Mozambique tilapia (Oreochromis mossambicus) in ...
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Series Introduction: Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair
... family. Activation of TLR/NF-κB is regulated, at least in part, by binding of pattern recognition molecules that present carbohydrate peptide or lipid compo- nents of pathogens (for example, endotoxin and pro- teoglycan) ...
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Protein-protein interactions of transcription factor CREB 1
... Chapter 1) (Chrivia et a!., 1993), a 2 5 0 kD factor which the authors showed (by Far W estern) to interact specifically with the Seri33-phosphorylated form of CREB and which has since been shown to behave ...
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Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism
... Data shown here bring also evidence that extracellular Hsp70 not only fails to induce TNF-α production in hu- man monocytes, but that it down-regulates their capacity to produce TNF-α and IL-6 in response to LPS. The ...
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Pharmacological inhibition of the transcription factor PU 1 in leukemia
... As we had observed a reduction in mature myelomonocytic colonies upon treatment with PU.1 inhibitors, but persistence or even slight increases in more immature cells (CFU-granulocyte/ ...
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat
... Basal antisense transcription of the HTLV-1 3= LTR is con- trolled by Sp1 binding sites located in the U5 region (65) (see Fig. 4A). Next, to evaluate relative levels of JunD and HBZ across the U5 region of ...
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Expression Pattern of the Ets-related Transcription Factor Elf-1
... Taken together, these data were consistent with the Western blot and in situ hybridization anal- yses of normal mouse tissues demonstrating that Elf-I is expressed at low levels in many [r] ...
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Transcription factor Fra 1 targets arginase 1 to enhance macrophage mediated inflammation in arthritis
... The data presented in this study show that the AP-1 transcrip- tion factor Fra-1 is a central regulator of macrophage function in arthritis. Fra-1 directly repressed proresolving Arg1 in ...
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Pathological transition as the arising mechanism for drug resistance in lung cancer
... express thyroid tran- scription factor-1 (TTF1, also known as NKX2-1) [4, 5], a p53-homologous nuclear protein mainly involved in basal cell ...
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Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin 1beta
... include transcription factors (panel A), cytokines, growth factors, and their receptors (panel B), proteases, matrix proteins, and adhesion molecules (panel C), as well as sig- naling intermediates and tumor ...
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