tuberculosis dormancy model and drug testing
Drug susceptibility testing for optimising tuberculosis treatment
... agar-based testing methods are considered less reliable. 23 Susceptibility testing on solid Löwenstein-Jensen media is acceptable according to some experts, 3 but is not used for drug susceptibility ...
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A Mathematical Model of Tuberculosis with Drug Resistance Effects
... deterministic model for the transmission dynamics of ...many tuberculosis models in literature, we include the class resistant to the first line of treatment for ...modeling tuberculosis in low and ...
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Conventional and radiometric drug susceptibility testing of Mycobacterium tuberculosis complex
... This observa- tion deserves further study, because it implies that the critical concentration of EB used in the standard PR method (Loewenstein-Jensen medi- um), cannot be equated to the[r] ...
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From competency to dormancy: a 3D model to study cancer cells and drug responsiveness
... Methods: In this study, we mimic different restriction forces that tumor cells are exposed to using a physiologically relevant 3D model with tunable mechanical stiffness. Results: Breast cancer MDA‑MB‑231, colon ...
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Second-line anti-tuberculosis drug resistance testing in Ghana identifies the first extensively drug-resistant tuberculosis case
... Mycobacterial isolates Isolates analyzed in this study were obtained from pulmo- nary patients attending various health facilities in the Accra Metro and the East Mamprusi District in the Greater-Accra and Northern ...
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The implications of model–informed drug discovery and development for tuberculosis
... a model-informed approach in clinical drug development Most of the known issues for the clinical development of anti-TB agents cannot be overcome by PreDiCT-TB ...individual drug exposure is not ...
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Mathematical analysis of a drug resistance in a tuberculosis transmission model
... For drug-susceptible active tuberculosis, a stan- dard 6-month treatment with 4 anti-tuberculosis medicines is administered through the provi- sion of information, surveillance and patient support ...
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Direct susceptibility testing for multi drug resistant tuberculosis: A meta analysis
... direct testing with the above mentioned ...direct testing, thereby delaying decisions on adoption of this approach for prompt detection of MDR ...direct testing against con- ventional indirect ...
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Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug Resistant Tuberculosis in Malatya, Turkey
... of drug-resistant isolates and acquired resistance due to treatment default and failure to the burden of drug resistance, we examined the number of drug resistance patterns observed within each ...
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Drug resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing
... diagnostic of DR-TB and initiation of treatment as well as estimates the prevalence of SLD resistance accurately [26]. In Mozambique there is a lack of information about re- sistance to the second line drugs. Samo Gudo ...
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Discordance across Several Methods for Drug Susceptibility Testing of Drug Resistant Mycobacterium tuberculosis Isolates in a Single Laboratory
... repeat testing due to contamina- ...repeat testing is required, the turnaround time doubles to 42 ...laboratory-specific drug pan- ...extremely drug- resistant isolates were subcultured on ...
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NON-COMMERCIAL CULTURE AND DRUG-SUSCEPTIBILITY TESTING METHODS FOR SCREENING OF PATIENTS AT RISK OF MULTI-DRUG RESISTANT TUBERCULOSIS
... • Phage-based assays: Assays which uses bacteriophages to infect and detect the presence of viable M. tuberculosis in clinical specimens and culture isolates. In 2009, the strength of the evidence for these ...
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Introduction. Keywords drug development, drug-resistant tuberculosis, drug-susceptible tuberculosis, multidrug therapy
... for drug-susceptible TB is one of non- ...led drug developers to select the use of superiority trial designs in MDR-TB patients, that entail testing the new drug against placebo, in ...
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Evaluation of Molecular Tools for Detection and Drug Susceptibility Testing of Mycobacterium tuberculosis in Stool Specimens from Patients with Pulmonary Tuberculosis
... past tuberculosis treatment, or if their disease does not im- prove during the first months of ...MDRTB testing of follow-up samples collected dur- ing therapy is microbiologically challenging because ...
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The antifibrotic drug pirfenidone promotes pulmonary cavitation and drug resistance in a mouse model of chronic tuberculosis
... those with latent TB infection. This is especially important since the approval of the only 2 orally available drugs, pirfenidone and nintedanib, has ushered in an important new management modality for IPF. In light of ...
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Early results of systematic drug susceptibility testing in pulmonary tuberculosis retreatment cases in Cameroon
... through drug vendors in the informal sec- ...and testing for HIV with consequent Co-trimoxazole prophylaxis is offered free-of-charge to all newly diagnosed ...
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Interlaboratory drug susceptibility testing of Mycobacterium tuberculosis by a radiometric procedure and two conventional methods
... A total of 224 recent isolates of Mycobacterium tuberculosis from 163 patients selected to have multidrug resistance were tested against streptomycin (SM), isoiiazid, rifampin, and etham[r] ...
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Quantitative Drug Susceptibility Testing of Mycobacterium tuberculosis by Use of MGIT 960 and EpiCenter Instrumentation
... of drug-resistant Mycobacterium tuberculosis strains are on the rise, the simple classification into “susceptible” and “resistant” strains based on susceptibility testing at “critical concentrations” ...
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Performance of Tuberculosis Drug Susceptibility Testing in U S Laboratories from 1994 to 2008
... proficiency testing or external quality assessment program, the participants know they are being tested, so there is always the possibility that results may not reflect routine ...or testing process and ...
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Current Perspectives on Drug Susceptibility Testing of Mycobacterium tuberculosis Complex: the Automated Nonradiometric Systems
... M. tuberculosis H37Rv (ATCC 27294) strain is currently recommended by the CLSI ...when testing both critical (low) and high drug concentrations, the ideal reference strain would be the one that is ...
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