-Tubulin Acetylation
The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells
... addition, acetylation of α-tubulin and HDAC6 inhi- bition enhance autophagy in non-small cell lung cancer ...α-tubulin acetylation between apoptosis and autophage is not well known and even ...
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HDAC3 promotes meiotic apparatus assembly in mouse oocytes by modulating tubulin acetylation
... - tubulin heterodimers (Nogales, 2000). Tubulin is one of the most abundant non-histone proteins subject to ...-tubulin acetylation serves as a marker for the presence of stable microtubules ...
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Role of α Tubulin Acetylation and Protein Kinase D2 Ser/Tyr Phosphorylation in Modulation by Ghrelin of Porphyromonas gingivalis Induced Enhancement in Matrix Metalloproteinase 9 (MMP 9) Secretion by Salivary Gland Cells
... its tubulin subunit acetylation on Lys 40 [11] [15], we have monitored the impact of ...-tubulin acetylation is reversible [11] [42], and hence presents a tempting target for therapeutic ...
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Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics
... of tubulin (Sirajuddin et al., 2014). Tubulin acetylation is a post-translational modification that alters the microtubule structure and affects the interaction between microtubules and ...
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Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis
... on tubulin acetylation in mouse oocyte ...acetylated tubulin level, which might be the reason for the spindle organization defects after Kif18a knock down in oocyte meiosis, and the decreased ...
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TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii
... -tubulin acetylation parallel the effects observed when microtubules are destabilized with oryzalin (13, 14, 39, 56, ...K40 acetylation, as we detect numerous structures resembling daughter caps that ...
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Histone Deacetylase 3 indirectly modulates tubulin acetylation
... on tubulin acetylation ...increased tubulin acetylation levels, but at higher concentrations (5 or 10 μ M), levels of tubulin acetylation ...acetylated tubulin (Figure ...
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Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy
... inhibition, tubulin acetylation [23]. We evalu- ated tubulin acetylation by Western blot after treatment with TDPs and FK228 at drug concentrations that inhibited cell viability and induced ...
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The diversity of acetylated proteins
... for acetylation of tubulins was obtained with a flagellar tubulin from the unicellular alga Polytomella ...[38]. Tubulin acetylation has since been observed in verte- brates, insects, ...
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Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated α-Tubulin Enhances Viral Replication
... -tubulin acetylation using the pharmacological inhibitor trichostatin A (TSA), RNA interference (RNAi) knockdown of the deacetylase enzymes histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2), or expression ...
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<p>Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines</p>
... β tubulin, are highly dynamic structures and represent the target of tubulin- binding anti-cancer ...29 Tubulin acetyla- tion is an indicator of microtubule ...in tubulin acetylation ...
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Original Article Chronic pethidine treatment induces histone H3 acetylation in rat brain
... histone acetylation at specific gene pro- ...histone acetylation and gene expres- sion, the levels of H3 acetylation at the promot- ers of these genes were analyzed in the subicu- lum of hippocampus ...
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Deciphering the Regulatory Circuitry That Controls Reversible Lysine Acetylation in Salmonella enterica
... Pat does not acetylate IolR and is not required during growth on myo-inositol. IolR represses the expression of genes encoding myo-inositol-degrading enzymes (16, 27), and it was surprising to find that IolR may also ...
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The acetylation and methylation of starch
... chloroform from water and from an aqueous solution of potas sium carbonate trimethyl methylglucoside and dimethyl methylglucoside were obtained In the proportion of 7*3 ^ 4.7 The monome[r] ...
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Archaeal origin of tubulin
... one of the subunit of the ESCRT-III complex (Figure 1B). The ESCRT-III complex is conserved in all eukar- yotes and is involved in intracellular membrane remo- deling [17]. Recently, archaeal homologs of ESCRT-III ...
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Small Molecule Acetylation Controls the Degradation of Benzoate and Photosynthesis in Rhodopseudomonas palustris
... BadL is required for the expression of the genes encoding enzymes that dearomatize the benzene ring. As shown by in vivo data (Fig. 2A and B), R. palustris requires BadL function to grow on benzoate as the source of ...
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Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter.
... ment located furthest upstream of the Cp known to affect Cp activity, the FR located within the origin of plasmid replication (30). It also contains restriction sites introduced to facilitate the isolation of discrete ...
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Paper 03-2013-2
... Extension of the axon with applied force leads to the disorder of tubulin concentration and provokes the diffusion of tubulin toward the growth cone and axonal elongation [r] ...
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Function of Tubulin Binding Proteins in Vivo
... of tubulin polypeptides into preexisting heterodimer in ...dissociated tubulin polypep- tides ...dissociated tubulin heterodimers and so rescue cells from the deleterious effects of free ...
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Glycolytic metabolism influences global chromatin structure
... effects, acetylation of lysine residues results in neutralization of the positive charges promoting an open chromatin configuration whereas histone de-acetylation is associated with a condensed compact ...
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