tumor angiogenesis
25 Years On: A Retrospective on Migration Inhibitory Factor in Tumor Angiogenesis
... into tumor microenvi- ronments, early studies clearly indicated a role for MIF as an endothelial cell-acti- vating proangiogenic cytokine that acts directly on ECs to enhance proliferation (3), motility (14) and, ...
6
Roles of Polo-like kinase 3 in suppressing tumor angiogenesis
... The association of Plk3 with tumor angiogenesis was discovered in a recent genetic study demonstrating that PLK3 null mice display an increased tumor incidence [19]. Importantly, tumors developed in ...
13
Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability
... require angiogenesis to grow beyond a certain ...and tumor necrosis factor ...pathological angiogenesis, implying that Piezo2 plays an anti- angiogenic role during tumor ...growth. ...
14
SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
... Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to ...VEGF-induced tumor angiogenesis both in vitro and in ...in ...
11
Computational Analysis of Tumor Angiogenesis Patterns Using a Two dimensional Model
... of tumor angiogenesis in which continuous or dis- crete models were ...of tumor angiogenesis using a combination of both the discrete and continuous ...a tumor angiogenesis ...
9
Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization
... increased tumor angiogenesis and vascular per- meability ...including tumor cells in which the expression of L1 per se promoted EMT (42, ...in tumor microenvironment and as a master ...
17
Neutrophils responsive to endogenous IFN β regulate tumor angiogenesis and growth in a mouse tumor model
... to tumor vascularization are not fully ...mouse tumor model, we have demonstrated that endogenous IFN-β inhibits tumor angiogenesis through repression of genes encoding proangiogenic and ...
15
ION CHANNEL MODULATORS AS ANTI-ANGIOGENIC TOOLS IN TUMOR ANGIOGENESIS
... channels (VGSCs) showed expression in both excitable and non-excitable cells [50] . They influence cell motility, cell proliferation, secretion, differentiation, and phagocytosis [51]-[54] . Thus, they play a vital role ...
15
Tryptase plays a role in solid tumor angiogenesis and cell proliferation
... VEGF expression on endothelial and intestinal cell surfaces is also increased by tryptase activated PAR-2, thus playing a role in tumor proliferation, growth, and angiogenesis. This theory was tested out in ...
7
The role of microenvironment in tumor angiogenesis
... to tumor angiogenesis, and there are many reports of associ- ations between macrophage infiltration, vascularity and ...prognosis. Tumor-associated macrophages accumulate in poorly vascularized ...
6
Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice
... associated inflammatory cells has a similar function. We found that Stat3 signaling mediates multidirectional crosstalk among tumor cells, myeloid cells in the tumor stroma, and ECs that contributes to ...
12
Transcription controlled gene therapy against tumor angiogenesis
... A major drawback of current approaches to antiangiogenic gene therapy is the lack of tissue-specific targeting. The aim of this work was to trigger endothelial cell–specific apoptosis, using adenoviral vector–mediated ...
9
Zebrafish embryo, a tool to study tumor angiogenesis
... Indeed, tumor-induced vessels show profound morpho- functional alterations when compared to the normal vasculature (Carmeliet and Jain, ...and tumor- derived endothelium (Ghilardi et ...which tumor ...
6
Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor
... induce angiogenesis during tumor ...Salmonella-treated tumor cells (B16F10 and ...two tumor cell lines varied, ranging from ...Salmonella-treated tumor cells (B16F10 and 4T1) than those ...
11
Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma
... that tumor angiogenesis is probably not the only pathway to affect prognosis for ...during tumor progression by reducing me- tastasis but at later stages, acting to promote proliferation and thereby ...
7
Original Article The value of tumor angiogenesis activity for stratification of HCC patients
... given therapy option. There is no doubt as to the presence of a tight link between the VEGF and VEGFR protein concentration in the tumor tissue and poor treatment outcome after surgi- cal treatment. Confirmation ...
14
Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice
... promote tumor angiogenesis, in part via a VEGF-independent mechanism, by recruiting inflammatory ...for tumor angiogenesis and tumor progression in several ways ...in tumor ...
15
Targeting prion like protein doppel selectively suppresses tumor angiogenesis
... therapy, but more studies are needed to completely define the role of doppel in the growth of tumoral blood vessels. Selective upregu- lation of doppel in TECs suggests that doppel targeting is unlikely to ...
17
Imaging Key Biomarkers of Tumor Angiogenesis
... of angiogenesis is expected to help in early diagnosis of primary tumor and emerging metastatic ...starve tumor to death resulted in enormous research and drug development efforts by countless ...
14
Establishing a Link between Oncogenes and Tumor Angiogenesis
... Oncogenes (and Tumor Suppressor Genes) and Angiogenesis Inhibitors The emphasis in this discussion has been on the idea that oncogenes can contribute to tumor an- giogenesis primaril[r] ...
10