Tumor antigen
Detection of JC Polyomavirus tumor antigen in gastric carcinoma: a report from Iran
... Regardless of PML (Progressive Multifocal Leu- koencephalopathy), a fatal CNS complication in im- munocompromised patients (10-12), infection with the JC virus has been considered subclinical in hu- mans. However, it has ...
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Nonidentity of Some Simian Virus 40-induced Enzymes with Tumor Antigen
... Acute simian virus 40 SV40 infection of monkey kidney cultures results in the early induction of an intranuclear tumor antigen T antigen, detectable by complement-fixation or immunofluor[r] ...
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The Raccoon Polyomavirus Genome and Tumor Antigen Transcription Are Stable and Abundant in Neuroglial Tumors
... P olyomaviruses (PyVs) infect a wide range of species, including humans. In well-studied PyVs, such as simian virus 40 (SV40), the oncogenic large tumor antigen (LT) protein is necessary and sufficient to ...
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Nature of Hamster Complement-fixing Antibody to Adenovirus 12 Tumor Antigen
... Nature of Hamster Complement-fixing Antibody to Adenovirus 12 Tumor Antigen Received for publication 10 April 1967 The presence of complement-fixing CF antibody reactive with T antigen a[r] ...
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Expression and thermal stability of simian virus 40 tumor-specific transplantation antigen and tumor antigen in wild type- and tsA mutant-transformed cells.
... Mice were followed for at least 5 weeks post challenge for ascites tumor development and On the other hand, a rat embryo transformed cell line, A28-RE, showed a dramatic drop in CF titer[r] ...
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Purification of a native membrane-associated adenovirus tumor antigen.
... To test this directly and to confirm that the protein present in various virus-transformed cells is identical to the E1B/15K protein, [35S]methionine-labeled cell extracts prepared from [r] ...
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Antigen delivery targeted to tumor associated macrophages overcomes tumor immune resistance
... Nanogel-based antigen delivery with a TLR agonist induces antigen presentation by ...of antigen pre- sentation by inactive TAMs is closely associated with immune resistance, we speculated that ...
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Oncogenic cancer/testis antigens: prime candidates for immunotherapy
... of tumor immunology suggests that tumor antigen-negative variants may evolve as the result of immunologic pressure, and thus it would be beneficial to target antigens, which, if lost, would reduce ...
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Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens
... of tumor antigen to DCs has been ...for antigen delivery ...the tumor lysate derived from solid-organ malignancies within PLGA spheres in humans ...for tumor lysates in murine and human ...
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<p>Exosomes as Actively Targeted Nanocarriers for Cancer Therapy</p>
... the tumor antigen is directly expressed on the surface without modi fi ...the tumor by mediating the immune ...and tumor growth factor- β (TGF- β 1) in tumor ...3LL tumor cells ...
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Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator.
... Positive and negative regulation of transcription in vitro: enhancer binding protein AP-2 is inhibited by SV40 T antigen.. Production of simian virus 40 large tumor antigen in bacteria: [r] ...
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A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.
... The large tumor antigen T antigen of simian virus 40 SV40 is a multifunctional regulatory protein that is required for a number of steps in productive viral infection, including DNA repl[r] ...
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PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses
... Antigen presentation is a crucial step in the initiation of an effective immune response. DCs have a unique ability to efficiently present antigens and thus play a central role in the orchestration of the adaptive ...
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Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation.
... We report here the isolation and characterization of in vitro-constructed amino acid substitu- The large tumor antigen T antigen of simian virus 40 SV40 is a regulatory protein that is e[r] ...
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Engineering switchable and programmable universal CARs for CAR T therapy
... However, the current modular design of the switching molecules relies on adding exogenous sequences/epi- topes. This process requires complicated recombinant engineering processes and also known target sequences. ...
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Insight into Merkel Cell Polyomavirus Replication Through the Study of the Viral Early Proteins: Large and Small Tumor Antigens
... Another MCPyV early protein is called small tumor antigen (sT), which shares the first N-terminal 78 amino acids with LT. This 186-amino acid protein is thought to play a more critical role in oncogenesis ...
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Antitumor Activity of T Cells Generated from Lymph Nodes Draining the SEA-expressing Murine B16 Melanoma and Secondarily Activated with Dendritic Cells
... of tumor-draining lymph nodes (TDLN) as a source of effector cells for cancer immunotherapy depends largely on the immunogenicity of the tumor drained by the lymph nodes as well as the methods for secondary ...
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Original Article Combination therapy of hepatic arterial chemoembolization and radiofrequency ablation for primary liver cancer
... the tumor lesion under CT guidance, and then a RF ablation device was started and lasted for 10-15 min, with the ablation power set at 80-100 W and the center temperature at ...
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Detection and characterization of mouse mammary tumor virus cell surface antigens: estimation of antigen abundance by protein A assay.
... 3 Detection and Characterization of Mouse Mammary Tumor Virus Cell Surface Antigens: Estimation of Antigen Abundance by Protein A Assay Antisera against the following mouse mammary tumor[r] ...
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KBMA Listeria monocytogenes is an effective vector for DC mediated induction of antitumor immunity
... Deletion of selected virulence proteins preserves the DC activation potential of L. monocytogenes. The ability of L. monocytogenes to infect phagocytic cells, as well as to access the host cell cytosol following the ...
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