Tumor Biology
Tumor biology and cancer therapy – an evolving relationship
... The aim of palliative chemotherapy is to increase survival whilst maintaining maximum quality of life for the individual concerned. Although we are still continuing to explore the optimum use of traditional chemotherapy ...
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Selecting patients with hepatocellular carcinoma for liver transplantation: incorporating tumor biology criteria
... limited tumor burden (under the so-called Milan criteria) are considered as potential can- didates for LT in most ...of tumor recurrence if patients with favorable biological behavior are carefully ...
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Thick primary melanoma has a heterogeneous tumor biology: an institutional series
... A noteworthy observation from our study is that 72.5% of our positive SLNB patients ultimately had only one positive node and only 22% of the CLND specimens had additional positive nodes on final pathology. Inter- ...
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The emerging role of voltage gated sodium channels in tumor biology
... The whole-cell patch clamp technique was employed to isolate and identify voltage-gated Na + currents as a major component of the inward flow in cervical cancer cells (35). While in normal cervical biopsies exclusively ...
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Hereditary paraganglioma : genetics and tumor biology
... It was recently proposed that a quantitative epigenetic switch, more pronounced in SDHB mutants than in other SDHx-related tumors, explains the increased malignancy risk conferred by SDHB mutations (2). Certain ...
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The role of mitochondrial DNA in the tumor biology of glioblastoma multiforme and multiple myeloma
... aggressive tumor is known as a secondary ...malignant tumor, estimated to affect 80% of adults diagnosed with primary brain cancer 156 ...brain tumor, classified as the most severe of its kind ...
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Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer
... cancer biology are still to be ...ensuing tumor progression looks logical in the context of hypoxia, which is known to promote tumor growth, chemoresistance, invasiveness, and metastasis ...With ...
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Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21
... of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Department of Oncology, Division of Surgery and Cancer and Transplantation Medicine, Oslo University Hospital, Oslo, ...
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MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
... Xenograft tumor take or growth rate was also not influenced by prior transient transfection with either CD9 or LacZ control vector in BE(2)-C cells subcutaneously implanted into CB17-SCID mice (Supplementary ...
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Association of Breast Cancer Risk with Genetic Variants Showing Differential Allelic Expression: Identification of a Novel Breast Cancer Susceptibility Locus at 4q21
... of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Department of Oncology, Division of Surgery and Cancer and Transplantation Medicine, Oslo University Hospital, Oslo, ...
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DCE-MRI, DW-MRI, and MRS in Cancer: Challenges and Advantages of Implementing Qualitative and Quantitative Multi-parametric Imaging in the Clinic.
... understanding tumor biology, where discordance between techniques may provide an understanding with underlying histopathology, which could then be clinically ...and tumor-specific antigens and ...
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The global cancer genomics consortium’s symposium: new era of molecular medicine and epigenetic cancer medicine - cross section of genomics and epigenetics
... and Tumor Biology at the Graduate School of Medicine Kyoto University presented a plenary lecture on mutational landscape and clonal architecture in low-grade ...
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Role of Molecular Biology in Cancer Treatment: A Review Article
... Tumor suppressor genes can be studied at the levels of DNA, mRNA, and proteins in the nor- mal and cancerous cells using various methods. Tests for the detection of heterozygosity can be helpful for identifying ...
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Phosphorylation of T-antigen and control T-antigen expression in cells transformed by wild-type and tsA mutants of simian virus 40.
... MARTIN'* Laboratory of Molecular Biology, National Institute ofArthritis, Metabolism and Digestive Diseases,' and Laboratory of DNA Tumor Viruses, National Cancer Institute,2 Bethesda, M[r] ...
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Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC
... Background: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways ...
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From the tumor inducing principle to plant biotechnology and its importance for society
... for tumor induction, but we also had to prove that introduction of such a plasmid in a non‐oncogenic strain, would make that strain ...the tumor‐inducing principle and they were therefore named the ...
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Aging: Past, Present and Future
... The discovery of telomerase in 1987 [59] lead to an understanding of how telomere attrition causes a DNA damage response (DDR), culminating in cell cycle arrest and cellular senescence [46, 60-62]. Recent findings show ...
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Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?
... inhibit tumor angiogenesis: 1) Angiogenic pathway blockades and 2) Endogenous angiogenesis inhibitors (Folkman, ...for tumor growth and metastasis (Cao et al., 2007) (Fig. 1). These tumor-derived ...
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Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature
... Estimated intraoperative blood loss was 200 mL and the opera- tive time was 100 minutes. The hospital stay was 7 days long. Seven days after surgery, serum creatinine and eGFR were 0.98 mg/dL and 81 mL/minute, ...
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Type 2B von Hippel-Lindau disease : molecular biology, tumor growth, and development
... Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer susceptibility syndrome resulting from germline mutation of the VHL tumor suppressor gene which affects 1 in 36,000 live births in the US ...
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