Tumor models
Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation
... utilized tumor models only poorly reflect relevant pathophysiology and, thereby, do not predict clinical applicability of novel pharmacological ...ACC models has remained a challenge with only one ...
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ANTITUMOR ACTIVITY OF CRATEVA MAGNA IN TRANSPLANTABLE TUMOR MODELS IN MICE:
... transplantable tumor models. Ascites tumor model is a type of rapidly growing carcinoma, which is inoculated in the outbred mice by serial intraperitoneal ...the tumor-bearing mice and ...
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Interleukin 13 receptor α2 DNA prime boost vaccine induces tumor immunity in murine tumor models
... We have previously demonstrated that splenocytes from C57BL/6 mice challenged with mouse melanoma (D5a2) when vaccinated with IL-13Ra2 DNA, mediated a significant lysis of target cells (38% lysis at E/T 50:1) [24]. ...
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Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models
... in tumor cell lines presenting different metabolic profiles ...prototypical tumor models in vivo, namely the glycolytic MDA- MB-231 human breast cancer model and the oxidative SiHa human cervical ...
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<p>Targeted delivery of doxorubicin to HER2 positive tumor models</p>
... Currently, the main approach of drug delivery is using arti fi cial nanoparticles such as liposomes to encapsulate and deliver chemotherapeutic drugs to tumor sites. Despite being widely used, synthetic particles ...
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Solving Discontinuous Collocation Equations for a Class of Brain Tumor Models on GPUs
... Simulations of the progress of untreated diffusive brain tumors are based on classical reaction-diffusion mathemat- ical models, such as in [1],[2] and [3]. Recently, Swanson ([4],[5]) introduced an appropriately ...
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An algorithm for classifying tumors based on genomic aberrations and selecting representative tumor models
... We applied our algorithm to datasets for NSCLC, CRC, and melanoma, each containing copy number profiles for hundreds of patient tumors and ~50 cell lines. The algo- rithm identified distinct new genomic subtypes for each ...
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Comparison of Multimodality Image Based Volumes in Preclinical Tumor Models Using In Air Micro CT Image Volume as Reference Tumor Volume
... soft tissue contrast even though tumors were located subcutaneously. Also the assumption of an ellipsoidal tu- mor shape in calculating tumor volumes caused a systematic error. The acquisition parameters for the ...
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Rabbit VX2 lung tumor models can form early nodal metastases
... A stock of VX2 tumor cells was propagated in rabbit hindlimb muscle, as previously described [11]. A total of 16 female New Zealand White (NZW) rabbits (Charles River, St. Constant, QC) weighing 3–3.5 kg were ...
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Effects of Kuan Sin Yin decoction on immunomodulation and tumorigenesis in mouse tumor models
... In the C3-B mouse model, the expression of the anticancer-associated cytokines (TNF- α , IFN- γ , IL-2, and IL-12) were measured by ELISA assay in the host spleen and the local tumor area. The result showed that ...
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The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma
... their tumor-specific profiles and further emphasize the importance of the genotype-specific context of mtDNA in investigating mtDNA methylation. The findings iden- tified by MeDIP further indicate that, among ...
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Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models
... cancer models, with or without and underlying BRAF or KRAS mutation [52, ...in tumor cellular contexts that are highly dependent on EGFR family signaling, such as the HER2 -amplified (Calu3) and EGFR ...
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Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma
... Different tumor models of ...vivo tumor formation, as well as the capability to form progeny with a more restricted fate (darker ...of tumor formation, which makes them all targets of ...
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Bioengineered models to study tumor dormancy
... mouse models, including genetic- ally engineered mouse models, orthotropic /subcutane- ous tumor models, tumor resection models, as well as experimental metastasis mouse ...
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Tumor endothelin 1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer
... in tumor macrophages (Figure ...in tumor- and host-derived IL-6 and MCP-1 in lungs but not in subcutaneous tumor lysates (data not ...subcutaneous tumor Figure ...
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Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion.
... are linked to the specific biological materials and protocols employed and hybrid organoid environment may substantially differ from the adult brain. Additional studies are required in terms of comparing stem cell-based ...
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Wilms tumor 1 (WT1) regulates KRAS driven oncogenesis and senescence in mouse and human models
... a tumor suppressor, considerable evidence points to a potential role for this protein as an onco- gene in other tumor types ...cell tumor (DSRBCT) carry an EWS-WT1 translocation (47, ...in ...
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Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models
... Protein-protein interactions and regulate the signal transduction circuitry play pivotal roles in tumor metastasis as well as angiogenesis. FGF2 regulates angiogenesis and by binding to its receptor FGF2R, which ...
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Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients
... cell models MCF-7, MDA-MB-231 and ZR- 75– 1; the cervical cancer cell line KB-3-1; the ovarian carcinoma A2780; the prostate cancer cell line PC-3; the osteosarcoma MG-63 and U2-OS; the multiple myeloma U266 and ...
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Hypoxia inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
... Hypoxia-inducible factor 1a (HIF-1a) and HIF-2a display unique and sometimes opposing activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis. Macrophages exposed to hypoxia accumulate ...
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