tumor promoter
Hepatitis B Virus X Protein Acts as a Tumor Promoter in Development of Diethylnitrosamine-Induced Preneoplastic Lesions
... Previous work with humans and woodchuck X-transgenic mice has established a cancer cofactor role for the HBx (or WHx) protein (13, 54, 58). The purpose of the present study was to investigate the molecular basis of the ...
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
... a tumor promoter came from experiments showing that SIRT1 physi- cally interacts with p53 and attenuates p53-mediated functions through deacetylation of p53 at its C-terminal Lys382 residue [12, ...many ...
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Original Article Up-regulation of the tumor promoter Glyoxalase-1 indicates poor prognosis in breast cancer
... Abstract: Glyoxalase 1 (Glo1) is an enzyme that plays a role to metabolize and inactivate methylglyoxal. Previous studies also have confirmed that Glo1 is closely related with tumorigenesis, metastasis, and ...
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Leucine-rich alpha-2-glycoprotein-1 is up-regulated in colorectal cancer and is a tumor promoter
... Background: Leucine-rich α-2-glycoprotein-1 (LRG1) is differentially expressed in many kinds of diseases including cancer, however, it has not been thoroughly studied yet. Purpose: The objective of this study was to ...
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Original Article PKCδ reveals a tumor promoter function by promoting cell proliferation and migration in somatotropinomas
... transduction [10, 11], cell proliferation [12], dif- ferentiation [13], migration [14], invasion [15] and apoptosis [16]. PKCδ, a subtype of PKC family, is involved in tumor progression of vari- ous tumor ...
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Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter induced transformation of JB6 cells
... for tumor promotion and neoplastic transformation, and are highly expressed in the promoter-sensitive JB6P + cells, and the inhibition of both or either one of these signaling pathways is sufficient to ...
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Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
... a tumor promoter, can cause either proliferation or cell cycle arrest, depending on cellular ...The tumor promoter PMA is a gero-promoter, which may be useful to study aging in ...
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Activation of latent Epstein-Barr virus genomes: selective stimulation of synthesis of chromosomal proteins by a tumor promoter.
... Although TPA is able to induce replication of EBV genomes in P3HR-1 cells in all phases of growth, the greatest increase in viral genome copies per cell 15-fold above the control level o[r] ...
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<p>The role of low density lipoprotein receptor-related protein 11 as a tumor promoter in cervical cancer</p>
... particularly transformation, progression, and metastasis, suggesting that bioactive lipids are mediators of a number of carcinogenesis processes. 3 The low-density lipoprotein receptor-related protein families are ...
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Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter
... DAB2 promoter could account for the low level of DAB2 expres- sion (Supplemental Figure 2A) in the 3 cell lines that displayed minimal promoter methylation (A431, SCC25, and ...DAB2 promoter ...
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Epigenetic downregulation of human disabled homolog 2 switches TGF β from a tumor suppressor to a tumor promoter
... minutes, then with or without 1 ng/ml TGF-β for a further hour. Cells were washed with PBS and fixed with 10% neutral buffered formalin for 1 hour at room temperature. Fixed cells were washed with PBS and resuspended in ...
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Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma
... Cervical cancer is the second most common malignant tumor after breast cancer in women worldwide [1]. Due to widespread practice of cervical screening, most cervical cancerous and precancerous lesions can be ...
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Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma
... the promoter region of TERT gene in several human tumors including melanoma, glioblastoma, bladder cancer, anaplastic thyroid cancer and HCC ...TERT promoter mutations have been also identified as a ...
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Synergistic Action of GA-Binding Protein and Glucocorticoid Receptor in Transcription from the Mouse Mammary Tumor Virus Promoter
... Formation of heterotetrameric complexes. GABP forms an ␣22 tetramer on tandemly arranged sites (like those in the immediate-early promoter of herpes simplex virus) through a leucine zipper domain at the carboxyl ...
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Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients
... ABCC1 promoter which was found to be hypomethylated (methylation status < LOQ) in all tumor, tumor-adjacent and tumor-distant tissues, the ABCB1 and ABCG2 promoters were found to be ...
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LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition
... and facilitated promoter access for transcription factors and cofactors, with the help of NF-Y. In the second scenario, HDAC inhibitors might impact directly on NF-Y, as suggested by binding of both histone acetyl ...
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Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non Hodgkin and Hodgkin lymphomas
... Deletions of the 3p22-21.3 region have been identified as one of the earliest molecular events in various malig- nancies [3], including naspharyngeal [4], head and neck [5], lung [6], gastric [7], breast [8], cervix [9] ...
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Homeobox D10 Gene, a Candidate Tumor Suppressor, Is Downregulated through Promoter Hypermethylation and Associated with Gastric Carcinogenesis
... HoxD10 promoter frequently was detected in gastric cancer cell lines, as well as in primary gastric cancer tissues (see Figure 7C, ...of tumor suppressor genes (TSGs) in can- cer cells ...though ...
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Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
... within promoter-proximal regions, we have found that approximately 50% of the p53-associated promoters con- tain a p53 consensus site [30], whereas only 20% of the p73-associated promoters contain such a consensus ...
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Prognostic value of aberrant promoter hypermethylation of tumor-related genes in early-stage head and neck cancer
... sex, tumor site, smoking status, alcohol exposure, tumor size, lymph node status, stage, and recurrence events were obtained from clinical ...neck tumor tissues and adjacent normal mucosal tissues ...
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