tumor suppressor in mice
Cop1 constitutively regulates c Jun protein stability and functions as a tumor suppressor in mice
... the tumor suppressor p53 as its ...hypomorphic mice spontaneously developed malignancy at a high frequency in the first year of life and were highly susceptible to radiation-induced ...a tumor ...
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CBX7 is a tumor suppressor in mice and humans
... generated mice null for Cbx7. Mouse embryonic fibroblasts derived from these mice had a higher growth rate and reduced susceptibility to senescence compared with their WT ...Cbx7-KO mice developed ...
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The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice
... the tumor spectrum of p53 mutant mice from lymphoma toward epithelial carcinomas (Table 3), similar to telomerase overexpression (31), telomerase knockout (33), or telomere deprotection ...haploinsufficient ...
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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice
... molecular tumor subclasses and their respective driver genes presents ...bone tumor suppressor gene capable of directing subclass development and driving RANKL overexpression during OSA ...Thus, ...
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CP 31398 restores mutant p53 tumor suppressor function and inhibits UVB induced skin carcinogenesis in mice
... both tumor and perilesional skin following ...wild-type mice but not in their p53-deficient ...p53 tumor suppressor functions in vivo by ...
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Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice
... male mice carrying a heterozygous deletion of p53 and an activated HER-2/ neu transgene (BALB-p53Neu mice), that develop urethral rhabdomyosarcomas with nearly full penetrance and early onset (4 months of ...
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Compensation by tumor suppressor genes during retinal development in mice and humans
... It has been shown previously that retinoblastoma forms in Rb;p107-deficient retinas [10,11,14,15]. Therefore, we propose that reciprocal compensation between Rb and p107 in retinal progenitor cells prevents ...
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Tumor suppressor in oral carcinogenesis
... knockout mice due to the absence of all TAp73 and ΔNp73 isoforms (Kazushi Inoue and Elizabeth ...all tumor cells, while only basal cells were stained in well differentiated carcinomas as in normal ...
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The Smads
... flies, mice and ...in mice has revealed their importance in embryonic development, and a tumor-suppressor role for Smads in human cancers has been ...
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Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
... KO mice com- pared to WT mice (Figures 3C and 3D), and these results indicated that the absence of Nrf2 augmented the expression of matrix-degrading proteinases, includ- ing pro-MMP-9, in response to UVB ...
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Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors
... Pten tumor suppressor gene in the thyroid follicular cells exhibit constitutive PI3K pathway activation and develop, from birth, hyperplastic glands that progress to nodular lesions by 6-10 months of age ...
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Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer
... and mice models has revealed their role as a negative growth regulator and tumor suppressor (Justice et ...a tumor suppressor in human (Tao et ...
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SOX17 is a tumor suppressor in endometrial cancer
... days. Mice were then euthanized and tumors were excised. Tumor weights (Figure 6C) and sizes (Figure 6D) from SOX17-overexpressing cells were reduced compared to ...
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
... On the other front, expression and/or activity of SIRT1 are also subjected to regulation by several tu- mor suppressors. Hypermethylated in cancer-1 (HIC1) encodes a transcriptional repressor with zinc finger motifs and ...
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Coadministration of doxorubicin and etoposide loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model
... model. Tumor-bearing mice treated with a combination of Dox and ETP loaded into CML-Lip showed increased survival and reduced tumor growth compared to other groups, including the combination of Dox ...
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von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia inducible factor 2α signaling and splenic erythropoiesis
... (VHL) tumor suppressor protein (pVHL) is unique in that it is not associated with tumor development, but rather with Chuvash polycythemia, a heritable disease char- acterized by elevated hematocrit ...
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The regulation of cellular metabolism by tumor suppressor p53
... null mice [19]. In another most recent study, mice bearing lysine to argin- ine mutations at three (p53(3KR); K117R+K161R+K162R) of p53 acetylation sites were ...null mice, which rap- idly succumb to ...
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DYRK1A in Down syndrome: an oncogene or tumor suppressor?
... The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus ...
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SETD2: an epigenetic modifier with tumor suppressor functionality
... In the past decade important progress has been made in our understanding of the epigenetic regulatory machinery. It has become clear that genetic aberrations in multiple epigenetic modifier proteins are associated with ...
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MTG16 is a tumor suppressor in colitis-associated carcinoma
... Immunohistochemistry. Five-micron sections of paraffin-embedded colons were cut and hematoxylin and eosin (H&E) staining was performed by the Vanderbilt University Translational Pathology Shared Resource. Histologic ...
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