tumour suppressor
Analysis of gene rearrangements and protein expression of the tumour suppressor genes, RB1 and p16, in acute myeloid leukaemia: Possible roles in leukaemogenesis
... retinoblastoma tumour cells had interstitial deletions affecting the q14 band of chromosome 13 (Yunis and Ramsay, ...Wilm's tumour cells revealed a specific loss of genetic material associated with the p i ...
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A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation
... Here, we report the characterisation of a new isoform of the tumour suppressor gene TSC2 which is derived from an internal androgen-regulated alternative promoter and has potentially oncogenic activity. ...
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Interaction of the growth and tumour suppressor NORE1A with microtubules is not required for its growth suppressive function
... Background: The NORE1 protein was identified in a yeast two-hybrid screen as a Ras effector that binds Ras protein in a GTP-dependent manner. NORE1A is a growth and tumour suppressor that is inactivated in ...
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Mutations in the von Hippel-Lindau Tumour Suppressor Gene in Central Nervous System Hemangioblastomas
... 9. Tse JY, Wong JH, Lo KW, Poon WS, Huang DP and Ng HK. Molecular genetic analysis of the von Hippel-Lindau disease tumour suppressor gene in familial and sporadic cerebellar hemangioblastomas. Am J Clin ...
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Nuclear factor one B ( NFIB ) encodes a subtype-specific tumour suppressor in glioblastoma
... Here we report that NFIB expression correlates inversely with astrocytoma grade. In GBM, NFIB expression is lowest in mesenchymal GBM, highest in proneural GBM and is associated with significantly improved survival in ...
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Characterization of a tumour suppressor function of RanBPM
... of tumour development including cell growth, proliferation, differentiation, and migration ...the tumour suppressor p73 and Mammalian Lethal Giant Larvae-1 (Mgl-1) [17, ...a tumour ...
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NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines
... of tumour sup- pressor genes, by loss of alleles. In case of tumour suppressor genes, usually both alleles must be inactivated in order to abrogate the function of a gene, which can be achieved by ...
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CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma
... CMTM4 is the most conserved member of this family and forms a gene cluster with CKLF and CMTM1-3 on chromosome 16q22.1, a locus that is frequently deleted or modified in multiple tumours and that harbours a number of ...
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Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes
... a tumour suppressor function ...Wilms' tumour suppressor protein Wt1 [28] and has also been shown to have a highly conserved 3' UTR which through miRNA activity regulates the mRNA levels ...
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A study of the role of oncogenes and tumour suppressor genes in malignant pancreatico-biliary tumours
... and tumour suppressor genes is still awaited in the clinical ...and tumour suppressor genes which control cell proliferation are also implicated in programmed cell death and ...
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Study of tumour suppressor genes in malignant tumours of liver, pancreas and biliary system
... Inactivation of tumour suppressor activity of the wild type p53 is an almost universal step in the development of human cancers. This has in turn stimulated an intense search for the biochemical and ...
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Tumour suppressor function of MDA-7/IL-24 in human breast cancer
... activity, tumour- specificity and efficacy across a spectrum of human can- cers have yet to be fully ...specific tumour suppressor function may not be entirely dependent upon these pathways ...
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O -mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer
... In this study we have demonstrated that protein O-mannosylation in human gastric cancer patients is overall reduced, suggesting that the O-mannosylation profile of several glycoproteins are changed affecting thereby the ...
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Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim
... Using recombinant viruses established with a bacterial artificial chromosome (BAC) system, we recently showed that EBNA3A and EBNA3C are both necessary for repression of the cellular gene Bim [4]. The Bim protein (Bcl-2 ...
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<p><em>Cadherin-11</em> is inactivated due to promoter methylation and functions in colorectal cancer as a tumour suppressor</p>
... a tumour suppressor gene. The tumour suppressor gene inactivation is closely related to epigenetic ...in tumour cell lines by perform- ing 1-Mb array comparative genomic hybridization ...
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MicroRNA profiling of the pubertal mouse mammary gland identifies miR 184 as a candidate breast tumour suppressor gene
... miR-184 is epigentically silenced in human cancers There is emerging evidence for epigenetic silencing by hypermethylation [48] of miRNAs with tumour suppressor properties or growth inhibitory functions in ...
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TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer
... the tumour suppressive function of TMEM196 in lung cancer, functional analysis of TMEM196 was performed in vitro and in ...and tumour formation in nude ...a tumour suppressor in lung ...the ...
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Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction
... novel tumour suppressor that exhibits tyrosine phosphatase activity as well as homology to the cytoskele- tal proteins tensin and auxilin ...certain tumour-like features such as attach- ment to ...
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No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer
... Background: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Increased succinate or fumarate levels ...
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Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma
... RB1 tumour suppressor gene (TSG) inactivation by promoter hypermethylation 17 years ago (Ohtani-Fujita et al 1993) it has become increasingly apparent that tumour suppressor promoter ...
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