type I interferons
Overview of the biology of type I interferons
... Firstly, type I interferons are widely used for the treatment of chronic viral infections, mainly by hepatitis B virus and hepatitis C virus ...that type I interferons are not ...
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Effects of Type I Interferons on Friend Retrovirus Infection
... that type I IFN negatively regulates CD8 ⫹ T-cell responses after DNA vacci- nation ...class I tetramer-positive CD8 ⫹ T cells between IFNAR and wild-type mice after FV infection (data not ...
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Species independent bioassay for sensitive quantification of antiviral type I interferons
... Type-I interferons (IFN-a/b) are potent cytokines that can be released from virtually all vertebrate cells follow- ing viral infection. They comprise a large number of IFN- a subspecies and a single ...
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Effects of Type I Interferons on the Adjuvant Properties of Plasmid Granulocyte-Macrophage Colony-Stimulating Factor In Vivo
... of type I interferons were also detected in the ...As type I interferons have been reported to damp foreign gene expression in vivo, we examined the possibility that these local ...
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Type I interferons regulate immune responses in humans with blood-stage Plasmodium falciparum infection
... identify type I interferons (IFNs) as important regulators in developing anti- parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum .... Type ...
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Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I Interferons
... This type of immune response is crucial for the clearance of virus infection and for long-term protection against ...reinfection. Type I interferons (IFNs), the primary innate cytokines that ...
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Evidence for a Different Susceptibility of Primate Lentiviruses to Type I Interferons
... Type I interferons induce a complex transcriptional program that leads to a generalized antiviral response against a large panel of viruses, including human immunodeficiency virus type 1 ...
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Type I Interferons Are Associated with Subclinical Markers of Cardiovascular Disease in a Cohort of Systemic Lupus Erythematosus Patients
... Type I interferons (IFNs) appear to play major pathogenic roles in SLE [17] and their increased levels are reported in lupus blood and tissues ...that type I IFNs induce abnormal ...
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Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ
... Type I interferons alpha and beta (IFN- ␣ and IFN-  ) play key roles in both innate and adaptive immunity (17). Viral infection activates cellular signaling pathways through various pattern ...
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Vaccinia Virus K1L and C7L Inhibit Antiviral Activities Induced by Type I Interferons
... Construction of mutant viruses. (i) vK1L ⴚ C7L ⴚ /GFP ⴙ . vK1L ⫺ , a K1L dele- tion mutant of WR VACV, was described previously (19). vK1L ⫺ C7L ⫺ /GFP ⫹ was constructed by replacing the C7L gene of vK1L ⫺ with ...
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Type I Interferons Are Essential in Controlling Neurotropic Coronavirus Infection Irrespective of Functional CD8 T Cells
... class I heavy chains, nonclassical class I molecules, and multiple cofactors involved in class I antigen processing ...class I upregulation in microglia following sublethal MHV-JHM infection ...
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Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver
... Induction of IFN-α/β protein in liver. As IFN- α / β can have profound effects on cell trafficking (13–16) and on cytokines and chemokines (11, 12), liver IFN-α/β expression was examined by immunohistochemistry. Tissue ...
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Partial Inhibition of Human Immunodeficiency Virus Replication by Type I Interferons: Impact of Cell-to-Cell Viral Transfer
... Like other virus species, HIV encounters the antiviral effects of type I IFN in infected individuals and has evolved multiple strategies to overcome these constraints. Some viral proteins, including Vpu and ...
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Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection
... NK cells are a second line of SSM defense. The finding that IFNAR blockade did not increase MuHV-4 passage through SSM implied additional, IFN-I-independent restriction, before adap- tive immunity comes into play ...
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Type I interferons regulate susceptibility to inflammation-induced preterm birth
... all type I IFN family members remains ...a type I IFN family member that is constitutively expressed by epithelial cells of the female reproductive tract and pro- tects from common sexually ...
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Identification and Characterization of Novel Type I Interferons in Pteropus vampyrus Bats.
... individual interferons [175-177]. How different interferons are able to produce different biological actions through the same receptor and highly conserved downstream signaling is not fully ...the ...
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Alphavirus evasion of type I interferons
... cell type. However, we saw no differences in the type I IFN induction phenotype for mam- and mos-RRV virus stocks, regardless of whether the virus stocks had equivalent capsid/glycoprotein signal, or ...
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Impact of genotype 1 and 2 of porcine reproductive and respiratory syndrome viruses on interferon-α responses by plasmacytoid dendritic cells
... immunity. Type I interferons (IFN) are essential for mounting efficient antiviral innate and adaptive immune responses, but in a recent study, North American PRRSV genotype 2 isolates did not induce, ...
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Malaria parasite DNA harbouring vesicles activate cytosolic immune sensors
... P athogens are sensed by pattern recognition receptors (PRR) of the mammalian innate immune system, which directly recognize pathogen-associated molecular patterns (PAMP), and also host-derived damage-associated ...
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Rational combinations of immunotherapeutics that target discrete pathways
... including type I interferons, and express multiple costimulatory ligands; induction of a productive T cell response within lymph nodes; migration of activated T cells to the tumor microenvironment in ...
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