Type II interferon receptor
Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines
... lacking type I and/or type II IFN receptors have been gener- ated (10, ...that type I IFN receptor triggering is required for maximal T-cell expansion (47), cross-priming of CD8 ⫹ T ...
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Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection
... the type I, II, or III interferon receptors did not significantly alter the disease course from that observed in WT mice ...the type I interferon receptor was not necessary for a ...
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Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence
... Viral RNA was isolated from sera (70 μl/specimen) using the QIAmp Viral RNA Mini kit (Qiagen) and from tissue homogenates using TRIzol reagent (Life Technologies) according to the manufacturer’s protocol. Spleen, liver, ...
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Inhibition of type I and type II interferon signaling by alphavirus nonstructural proteins
... to type I and type II interferons (IFNs) by disrupting Jak/STAT signaling; however, the relevance of this signaling inhibition toward pathogenesis has not been ...IFN receptor-associated ...
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Viral Interferon Regulatory Factors Decrease the Induction of Type I and Type II Interferon during Rhesus Macaque Rhadinovirus Infection
... of type I and type II IFN during RRV infection in both tRFs and ...Toll-like receptor 7 (TLR7) and TLR9, which specifically equips them to recognize bacterial and viral nucleic acids, ...
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Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components
... deletion II (left-hand part of the CVA genome; encompassing nonessential genes M1L, M2L, and K1L), and deletion IV (right-hand part of the CVA genome; HindIII B fragment) ...
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Rinderpest Virus Blocks Type I and Type II Interferon Action: Role of Structural and Nonstructural Proteins
... the type I IFN receptor complex containing RACK1 and STAT1 and thus suppressing of IFN- ␣ signaling ...blocking interferon signaling; our observations on cells infected with RPV mutants that do not ...
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Discrepancy between the in vitro and in vivoeffects of murine mesenchymal stem cells on T cell proliferation and collagen induced arthritis
... collagen type II; COX-2: cyclo-oxigenase-2; DTH: delayed-type hypersensitivity; EDTA: ethylenediaminetetraacetic acid; EdU: 5-ethynyl-2 ’ - deoxyuridine; FCS: fetal calf serum; FITC: fluorescein ...
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PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer
... BMP receptor type 1; BMPR II: BMP receptor type 2; C2-type: constant 2-type; CCLE: cancer cell line encyclopedia; CD80: cluster of differentiation 80; GSEA: gene set ...
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Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response
... The immune modulation functions performed by herpesviral dUTPases may be mediated by a motif(s) and/or structures that are of viral origin. dUTPases are ubiqui- tously expressed in most organisms, including prokaryotes, ...
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Activin signaling as an emerging target for therapeutic interventions
... After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities ...
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Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection
... early type I IFN responses did not affect the reduced susceptibility that was found in the mice deficient in IFNAR at day 7, further supporting our position that a switch in the immune response occurs during the ...
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Porcine Epidemic Diarrhea Virus-Induced Epidermal Growth Factor Receptor Activation Impairs the Antiviral Activity of Type I Interferon
... a receptor tyrosine kinase, serving as a homeostatic regulator of cell proliferation, differentiation, adhesion, and survival (21, ...of interferon-stimulated genes and boosts the antiviral efficacy of ...
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Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the interferon response
... Atwan, Zeenah, Wright, Jordan L., Leppard, Keith and Woodman, Andrew. (2016) Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the ...
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Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by Transforming Growth Factor β and Angiotensin II.
... TGF-β receptor in the cae- cum, which are increased after LS diet (p < ...β receptor on capillary endothelial cells may restore endothelial function, at least in ...
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Topoisomerase II Inhibitors Induce DNA Damage Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion
... An HTS assay to identify small-molecule inhibitors of VP35. A 293T-based stable cell line with a firefly luciferase reporter gene under the control of the IFN-  promoter (293T-FF) was transduced with a lentivirus that ...
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Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors
... monocytes. Administration of rIFN-gamma in vivo also causes enhanced Fc gamma RI expression on these cell populations. Because streptococcal antigens are potent inducers of IFN-gamma in vitro, we postulated that ...
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Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction
... 1994). Type Ib (big) boutons are surrounded by a prominent Dlg-positive SSR, whereas the Dlg-positive SSR enveloping type Is (small) boutons is less ...wild type, the overall proportion with strong ...
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Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis
... Neutrophil recruitment and migration were analyzed by transendothelial migration and ROS generation. Superna- tants of SSc-IgG-treated HMEC-1 increased healthy donor neutrophil migration through an endothelial cell layer ...
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Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
... increased type I interferon signaling contrib- ute to the toxicological effects of GMA-SS? One poten- tial role for Irf7 is ...related type I interferon signaling in the aorta ...of ...
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