Type Three Secretion System and Effectors
Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition
... expand the series, it was decided to replace the car- bonyl function with a sulfone group, creating further derivatives for testing. One key advantage of AV compounds compared with traditional antibiotics is the reduced ...
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Targeting of Flavobacterium Johnsoniae Proteins for Secretion By the Type IX Secretion System
... with type B CTDs but eleven species had predicted proteins with type A ...with type A CTDs (ranging from 18 to 147), suggesting a link between type A CTDs and the large outer membrane protein ...
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Activation and Inhibition of Multiple Inflammasome Pathways by the Yersinia Pestis Type Three Secretion System: A Dissertation
... Immune evasion by T3SS pathogens related to Y. pestis Pathogens use secretion systems to export molecules which can manipulate the host environment and promote bacterial fitness. The survival strategy of Y. ...
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Regulation of type III secretion system in Pseudomonas syringae
... known regulators. KB/pin/min/fin genes may regulate the known TTSS gene regulatory genes at posttranslational level, and this can be determined by examining the known regulatory proteins in the KB/pin/min/fin mutants by ...
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The Type III Secretion System of Pathogenic Escherichia coli
... et al. 2015). As such, ETT2 classi fication may provide an insight into the phylo- genetic origin of E. coli isolates. A secretion-competent ETT2 has never been identi fied, therefore the question of its function ...
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Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein.
... truncated secretion construct, a number of indings provided new information on the roles of the secretion signal peptide and UTRs of FliC ...FT3SS secretion platform could become a forerunner for use ...
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Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion
... protein secretion by employing the same protein components was ...promotes secretion of intermediate T3SS substrates, ...of secretion and expression ...and secretion by component migration ...
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Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein
... prototype secretion construct ...in secretion efficiency ...protein secretion assay was carried out ...the secretion construct (SC1) ...
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LcrH, a Class II Chaperone from the Type Three Secretion System, Has a Highly Flexible Native Structure
... The type three secretion system is a large and complex protein nano-machine that many Gram-negative pathogens employ to infect host ...effective secretion and thus pore formation of the ...
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Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.
... because type IV secretion is generally thought to involve substrate unfolding ( Cabezon et ...effector-secreting type III secretion systems and also not uncommon for other host-targeting T4SS ...
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SsaV Interacts with SsaL to Control the Translocon to Effector Switch in the Salmonella SPI 2 Type Three Secretion System
... mediates secretion of translocon proteins until neutral pH is sensed, which causes their dissociation, resulting in arrest of translocon secretion and derepression of effector ...SPI-2 type III ...
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A putative lytic transglycosylase tightly regulated and critical for the EHEC type three secretion
... are three enzymes found in this family: flgJ for constructing flagellum [23], pilT for the assembly of pilus [24] and l0045 in the LEE ...decreasing secretion of Tir, EspB and EspA when compared to that of ...
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Current knowledge on the Ralstonia solanacearum type III secretion system
... T3SS regulation in planta An experimental limitation of the above described regula- tory circuits is that they were all defined based on experi- ments carried out in vitro using synthetic media. Recent research has ...
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The Type VI Secretion System in Escherichia coli and Related Species
... Escherichia coli Salmonella Shigella Enterobacter Citrobacter.. Plus.[r] ...
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Structural Basis for the Secretion of EvpC: A Key Type VI Secretion System Protein from Edwardsiella tarda
... the three major EVP secreted proteins and shares high sequence similarity with Hcp1, a key T6SS virulence factor from Pseudomonas ...the secretion of ...
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Structural insights into the function of type VI secretion system TssA subunits.
... A final question is to consider the mismatch in symmetry between the assemblies formed by members of different TssA clades, on the one hand, and other components of the T6SS, on the other, and how this impacts on the ...
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Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli
... E.M. and K.B. contributed equally to this article. ABSTRACT Type III secretion systems (TTSSs) are employed by pathogens to translocate host cells with effector proteins, which are crucial for virulence. ...
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The architecture of EssB, an integral membrane component of the Type VII secretion system
... bacterial type VII secretion system that can contribute to ...or secretion system ...the secretion apparatus, which is embedded in the cytoplasmic membrane with the C-terminal ...
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Identification of sequence motifs for the protein components of type IX secretion system
... PorT as the putative lipid A 3-O-deacylases. Experimental validations are required to validate the deacylase activities of PorP and PorT proteins. The identified motifs for five components of the T9SS, PorK, PorQ, Sov ...
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Exploration of chlamydial type III secretion system reconstitution in Escherichia coli
... While these approaches have yielded valuable information for the cT3SS, they both have limitations. Therefore, even though small T3SS inhibitors demonstrate specificity in targeting T3S in free- living bacteria, ...
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