Ubiquitin ligase (E3)
Putative E3 Ubiquitin Ligase of Human Rotavirus Inhibits NF κB Activation by Using Molecular Mimicry To Target β TrCP
... The E3 ubiquitin ligase SCF -TrCP recognizes this phosphodegron through its  -transducin repeat-containing protein (  -TrCP) subunit and induces I B degrada- tion, allowing NF- B to ...
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Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase
... bind ubiquitin enzymes or their sub- strates, hence functioning as E3 ligases ...an E3 ubiqui- tin ...pRK5-HA- ubiquitin-WT polypeptide ...tagged ubiquitin conjugated ...2A, ...
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The E3 ubiquitin ligase TRIM62 and inflammation induced skeletal muscle atrophy
... the ubiquitin-proteasome system (UPS) [10], which is activated in muscle of critically ill pa- tients [1,8,11] and involves the F-box adaptor protein FBXO32/Atrogin1 [12] and the E3 ubiquitin ...
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The RING Finger Domain of Varicella-Zoster Virus ORF61p Has E3 Ubiquitin Ligase Activity That Is Essential for Efficient Autoubiquitination and Dispersion of Sp100-Containing Nuclear Bodies
... an E3 ubiquitin ligase to target several host proteins for proteasomal ...has E3 ubiquitin ligase activity (4), and its presence results in decreased levels of Sp100 (8, ...
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Regulation of the Centromeric Histone H3 Variant Cse4 by the E3 Ubiquitin Ligase, Pshl
... An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain.. de FACTo nucleosome dynamics..[r] ...
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Autographa californica Nucleopolyhedrovirus AC141 (Exon0), a Potential E3 Ubiquitin Ligase, Interacts with Viral Ubiquitin and AC66 To Facilitate Nucleocapsid Egress
... Baculoviruses are unique, as they produce two structurally different virions: BV, which is required for systemic transmission, and ODV, which is utilized for interhost transmission. Nucleocapsids for both virion types ...
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The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1
... miR-1 is a small noncoding RNA molecule that modulates gene expression in heart and skeletal muscle. Loss of Drosophila miR-1 produces defects in somatic muscle and embryonic heart development, which have been partly ...
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Dissection of the HIV Vif Interaction with Human E3 Ubiquitin Ligase
... the E3 ligase with 1:1 ...human E3 ubiquitin ligase: the Vif BC box interacts with EloBC ...human E3 ubiquitin ligase machinery to evade the cellular innate immune ...
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The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation
... transmembrane domains to uncover new modulators of NF- κ B activation, using tumor necrosis factor –α (TNF- α ) receptor (TNFR) stimulation as a model. We report here the identification of a new Golgi Apparatus-resident ...
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Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4
... The present study focuses on the tumor suppressor protein Salvador (Sav), which, together with Hpo and Wts, was one of the first Hpo pathway components to be identified [5,6]. Sav is a WW domain-containing scaffold ...
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The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells
... Background: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide, and deciphering underlying molecular mechanism is essential. The loss of monoubiquitinated histone H2B (H2Bub1) was ...
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Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
... Furthermore, we examined whether binding of wild- type spartin to AIP4 in vitro also results in increased self-ubiquitination of AIP4. We investigated the levels of self-ubiquitination of the glutathione S-transferase ...
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Modulating Parkin E3 Ubiquitin Ligase Activity Using Phospho-Ubiquitin Variants
... Despite intense research on pUb S65 , little is yet known about how other phosphorylation sites on Ub modulate parkin activity. Both traditional and high- throughput proteomic investigations have identified variants of ...
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Regulation of the anaphase-promoting complex by phosphorylation
... polymeric ubiquitin chains and subsequent degradation of the protein by the 26s proteosome (Pickart, ...a ubiquitin-activating enzyme (E1) begins by hydrolyzing ATP to form a high energy thio-ester bond ...
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How to Orient Yourself in the Wilderness
... the E3 ubiquitin ligase activity; meaning that p53 is being ubiquitinated and proteosomally ...this ligase is through a negative feedback loop that uses overexpressed p53 to abolish the MDM2 ...
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DNA Replication Origin Function Is Promoted by H3K4 Di-methylation in Saccharomyces cerevisiae
... ABSTRACT DNA replication is a highly regulated process that is initiated from replication origins, but the elements of chromatin structure that contribute to origin activity have not been fully elucidated. To identify ...
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Parkinson’s disease-associated protein Parkin: an unusual player in cancer
... Parkin gene mutations linked to cancer are missense mutations, with > 10% involving frameshifts or trunca- tions [22]. Many missense mutations in cancer, such as T173A, T240M and P294S, impair E3 ...
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Degradation of Centromeric Histone H3 Variant Cse4 Requires the Fpr3 Peptidyl-prolyl Cis–Trans Isomerase
... To examine whether Fpr3 and Fpr4 regulate Cse4 pro- teolysis, we performed a protein stability assay (Figure 2). Cse4 was transiently induced from a GAL1 promoter by the addition of galactose. Then, glucose was added to ...
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Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads
... Eight E3 ligase inhibitors namely, thalidomide, proTAME, NSC 66811, Nutlin 3, HLI 373, JNJ 26854165, SMER 3 and NSC 146109 were used in the ...an E3 ubiquitin ligase complex with ...
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Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins
... an E3 ubiquitin ligase of the RING finger class that is required for efficient lytic infection and reactivation from ...have E3 ubiquitin ligase activity in ...
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