Ubiquitinated proteins
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus
... pro-survival proteins (see also ...pro-apoptotic proteins, followed by a qualitative in- crease in the number of degenerating ...damage proteins and aggresome-like structures ...of ...
10
<p>Anti-Tumor Efficacy of an Adjuvant Built-In Nanovaccine Based on Ubiquitinated Proteins from Tumor Cells</p>
... Recent studies have con fi rmed that DRibbles (defective ribosomal products-containing blebs) isolated from tumor cells with the induction of autophagy and inhibition of lysosomal/proteasomal activity are suf fi cient to ...
15
Ubiquitinated proteins enriched from tumor cells by a ubiquitin binding protein Vx3(A7) as a potent cancer vaccine
... short-lived proteins are not contained in inactivated whole tumor cells or tumor cell lysates vaccines due to rapid ...Ub-enriched proteins could in- duce higher immune response than whole tumor cell lysate ...
12
HIV-1 Vpr Redirects Host Ubiquitination Pathway
... Analysis of Vpr determinants critical for reducing whole-cell ubiquitination. Structure analysis by nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy showed that Vpr contains three helical domains ...
12
Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells
... induced ubiquitinated protein ac- cumulation ...unfolded proteins, which were then ubiquiti- nated, and bortezomib inhibited their ...The ubiquitinated protein accumulation is also in accordance with ...
9
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
... We found significant down-regulation of proteasome activities in Ctsd-/- brains. The reduction of proteasome activity may be due to reduced expression of UPS regula- tors and proteasome subunits, inactivating ...
18
SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI)
... weight ubiquitinated proteins fol- lowing forebrain ischemia ...These ubiquitinated- protein aggregates are visualized in cultured astrocytes following glucose deprivation/recovery ...misfolded ...
15
VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase
... UBX-domain proteins, most of which interact with the p97 ATPase via their C-terminal UBX-domain ...UBA-UBX proteins due to the presence of a ubiquitin-associated (UBA) domain at their N-terminus, which ...
20
Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model
... of ubiquitinated proteins [14], the levels of Ser403 (corre- sponding to mouse Ser405)-phosphorylated SQSTM1 be- tween SQSTM1;SOD1 H46R and SOD1 H46R mice were most comparable ...
16
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
... understood. Ubiquitinated protein aggregates, of which TDP-43 is a major component, are a characteristic pathological feature of most ALS and FTD ...of ubiquitinated proteins, including TDP-43 and a ...
8
Investigations into the significance of Nrf2 signalling and ubiquitination of proteins in Respiratory Syncytial Virus infection
... of proteins selected from the proteomics (DDX21, annexin A1, HMGB1, RPS10, prohibitin and ...are ubiquitinated proteins in the samples and if so, whether their amount changes following viral ...
179
The many faces of ubiquitinated histone H2A: insights from the DUBs
... towards ubiquitinated histones has not been ...of ubiquitinated proteins and ubiquitin receptors at the chromatin will potentially reveal novel players in ...
14
p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation
... The ubiquitin – proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body of ...
14
The synucleins
... soluble proteins expressed primarily in neural tissue and in certain ...known proteins: D -synuclein, E -synuclein, and J ...abundant’ proteins. The D - and E -synuclein proteins are found ...
6
Alpha synuclein in the neurodegenerative mechanisms of Parkinson's disease and dementia with Lewy bodies
... mitochondrial dysfunction in disease related neurodegeneration. These pathways are further implicated through pharmacological induction of Parkinsonism and PD, by MPTP and rotenone. However, there is little evidence ...
234
Characterization of a ubiquitinated protein which is externally located in African swine fever virions.
... Characterization of UB18 present in virions. Purified extra- cellular virions were extracted with 0.25% OG, and solubilized proteins were separated by SDS-PAGE and blotted onto a PVDF membrane. UB18 cross-reacted ...
9
Cryopreservation of fluorescence activated cell sorted boar spermatozoa based on extracellular ubiquitination
... ABSTRACT: The present study is focused on the methodology of fluorescence activated cell sorting (FACS) of spermatozoa stained by the antibody against extracellular surface marker ubiquitin (eUb) and subsequent protocol ...
7
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel–Lindau protein–interacting deubiquitinating enzymes regulates thyroid hormone activation
... Alto, California, USA) was used to screen for potential D2-interacting proteins. A human-brain cDNA library cloned into pACT2 such that it contains a GAL4 acti- vation domain (GAL4 AD) and an hemaglutinin (HA) tag ...
9
Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival
... One mechanism by which Degs1 might regulate cell survival is via ER stress, as lipid composition and particularly ceramide and dihydroceramide in the ER membrane activate ER stress responses (7, 16, 17). This can lead to ...
19
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
... more common RNA-binding proteins that reliably associates with the various types of stress granules and is therefore commonly used as a specific marker [49]. PABP-1 labels NCI in ALS-FUS with a R521C mutation, as ...
13