UCH-L1
Original Article The effect and mechanism of UCH-L1 inhibitor LDN-57444 on hypoxic/ischemic injury in neonatal rats
... in the perinatal stage of neonatal, and its com- mon pathogenesis is intrauterine fetal distress, which can be caused by various of causes such as umbilical cord around the neck, abnormality in amniotic fluid and so on. ...
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C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes
... of UCH-L1 results in reduced amounts of LMP1 in ...and UCH-L1 wild-type or mutant expression vectors, and exosome fractions were purified by ...
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Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study
... were obtained within 4 hours of time of injury. Repeated blood sampling was conducted for as long as the patient remained in hospital at 4, 8, 12, 16, 24, 36, 48, 60, 72, 84, 96, 108, 120, 132, 144, 156, 168 and 180 ...
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Original Article Wnt/β-catenin pathway involved in podocyte injury is regulated by UCH-L1
... Immunoprecipitation was performed according to a previously described protocol [22]. Briefly, cells were harvested and lysed in TNT buffer (20 mM Tris–HCl, pH 7.4, 200 mM NaCl, 1% Triton X-100, 10 mM iodoacetamide, 1 mM ...
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UCH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer
... of UCH-L1 correlated with negative ERα status and advanced tumor stage [37], yet whether UCH-L1 indeed has a role in the regulation of ERα remains largely ...that UCH-L1 ...
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Original Article UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer
... the UCH proteases family that deubiquitinates ubiquitin-protein conjugates in the ubiquitin-proteasome ...that UCH-L1 and EGFR could regulate the expression of P-gp, CD147 and MMPs in multi-drug ...
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Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure
... of UCH-L1 as a putative biomarker of neuronal injury and BBB dysfunction in patients after seizure in an emergency department, where this information could be critical to improve the manage- ment and guide ...
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Original Article Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma
... that UCH-L1, neural inva- sion, differentiation and tumor stage were inde- pendent predictors for the DFS of hilar cholan- ...giocarcinoma. UCH-L1, differentiation, TNM stage and tumor stage ...
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The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis
... 25-kDa UCH-L1 band during TNF-induced necroptosis was accompanied by the con- current appearance of a prominent band of ~35 kDa (Figure ...25-kDa UCH-L1 form (most clearly visible after 8 ...
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Original Article UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma
... cells, UCH-L1 has a wide interaction with various cellular signaling path- ways, such as mTOR [30], cyclins [28], Akt [31] and Wnt/b-catenin pathway ...that UCH-L1 might po- tentiate the ...
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Effects of postoperative dexmedetomidine sedation on nerve function, inflammation and oxidative stress in patients with craniocerebral injury
... markers UCH-L1 (ng/mL), NSE (ng/mL), GFAP (pg/ mL), BDNF (pg/mL) and NGF (pg/mL) between the two groups of patients was as follows: compared with those before surgery, UCH-L1, NSE and GFAP ...
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Identification of biomarkers for the detection of subtle brain injury after cannabis and/or tramadol administration
... that UCH-L1 and GFAP proteins in- creased in the brain and serum after cannabis and/or tramadol ...administration. UCH-L1 is abundant in neur- onal cell body and increased release of this ...
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Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma
... tissue, UCH-L1 promotes apoptosis. In testicular germ cells UCH-L1 expression is responsible for an early apop- totic wave during spermatogenesis but tight regulation of UCH-L1 ...
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Functional study of ubiquitin C terminal hydrolase L1 gene promoter haplotypes
... common UCH-L1 promoter haplotypes elucidated – AAGAC, GAGGT and AGAAC - were incorporated into a modified pGL3 vector to ascertain transcriptional activity ...
28
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4
... radical (OH·), have been shown to be up-regulated in the tumor microenvironment and trigger cell adhesion, cell migration and invasion [41]. NOX4 has been detected in focal adhesions [42], and on the plasma membrane ...
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Cabell_Chapter 1-5_V4.docx
... Concussions are a common injury in contact sports yet are difficult to diagnose. The current concussion assessment battery is not foolproof, and blood biomarkers are a possible solution to improve sensitivity. To ...
57
The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations
... As with the results from the mutant ORF2 proteins in the retrotransposition assays, we did not observe any additive effect on the ability of ENp to cause toxicity as the number of mutations was increased from one to four ...
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Scoring of PD-L1 expression intensity on pulmonary adenocarcinomas and the correlations with clinicopathological factors
... In our preliminary study, we noticed that AMs in NSCLC tissues were strongly stained with anti-PD-L1 antibody. AMs are localised in the air space of pulmon- ary alveoli, and are relatively larger in size (20 – 50 ...
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Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)
... Interestingly, the inhibitor binding induces a small, but significant rearrangement of the sidechains at the surface of PD-L1 (compared to the apo-structure), which is partly different to that induced by the PD-1 ...
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Autophagy inhibition enhances PD-L1 expression in gastric cancer
... PD-L1 expression in tumor cells could be triggered by intrinsic cellular signaling molecules, including NF-κB, MAPK, PI3K, mTOR and JAK/STAT [11]. The adaptor protein p62/SQSTM1 has been implicated in the activa- ...
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