UDP-glucuronosyltransferase (UGT)
Bucolome N Glucuronide Formation: Species Differences and Identification of Human UDP Glucuronosyltransferase Isoforms
... the UDP-glucuronosyltransferase (UGT) isoform (s) responsible for forma- tion of BCP-NG in ...the UGT isoforms involved in formation of BCP-NG in humans, we investigated BCP-NG formation by ...
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In vitro and in vivo effect of Eurycoma longifolia root extract on UDP-glucuronosyltransferase activity
... is that herbal drugs are natural, and therefore safe for consumption have resulted in many herbal products on sale in the market (Newall et al., 1996; Zhang et al., 2005). However, there are many possibilities that any ...
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Identification of a genetic alteration in the code for bilirubin UDP glucuronosyltransferase in the UGT1 gene complex of a Crigler Najjar type I patient
... glucuronosyltransferase (transferase) activity. The recent identification of two bilirubin transferase isoforms with identical carboxyl termini (Ritter, J. K., J. M. Crawford, and I. S. Owens. 1991. J. Biol. Chem. ...
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Characterization of Bucolome N Glucuronide Formation: Tissue Specificity and Identification of Rat UDP Glucuronosyltransferase Isoform (s)
... the UGT isoform distri- bution at the mRNA level in 10 rat tissues (liver, kidney, lung, stomach, duodenum, jejunum, ileum, large intestine, cerebellum, and cerebral cortex), in which 3 UGT iso- forms ...
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UDP glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
... contribute to sex hormone concentrations in vivo could not be considered as part of the study. As with any genetic association study, the results must be interpreted in the light of the possibility that observed ...
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Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1H-indazole (benzpyrazole)
... 188 mM HEPES buffer (adjusted to pH 7.5) were mixed with 40 μl of enzyme source (liver S9 fraction or SF9 insect cell microsomes (UGT supersomes™) and 10 μl of substrate solution (100 mM of 1 in DMSO) giving a ...
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Original Article Human UDP-glucuronosyltransferase 1A1, 1A7, 1A8, 1A9 and 1A10 are mainly responsible for icariside II-7- O-glucuronidation
... Abstract: Icariside II (IC-II) is a well-known flavonoid glycoside with many bioactivities in Epimedium plants. However, its glucuronidation involving human UDP-glucuronosyltransferases (UGTs) remains unclear. In ...
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Metabolic inactivation of estrogens in breast tissue by UDP glucuronosyltransferase enzymes: an overview
... by UDP-glucuronosyltransferases (UGTs), which involves the covalent addition of glucuronic ...the UGT-mediated process leads to the formation of glucuronides that are devoid of biologic activity and are ...
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PubMedCentral-PMC4876189.pdf
... that UDP-glucuronosyltransferase (UGT) 1A proteins and UGT2B7 are variably expressed throughout the tubule components of the human nephron ...from UGT 1A6 and 1A9 [2]), was ...
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Association of Neonatal Hyperbilirubinemia With Bilirubin UDP-Glucuronosyltransferase Polymorphism
... The missense mutation causing G71R is the first reported polymorphism for UGT1A1, and the mutation is a risk factor for nonphysiologic neonatal hyperbilirubinemia.. The high incidence of[r] ...
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Down-regulation of aminopeptidase N and ABC transporter subfamily G transcripts in Cry1Ab and Cry1Ac resistant Asian corn borer, Ostrinia furnacalis (Lepidoptera: Crambidae)
... Several uridine diphosphates (UDP)-glucuronosyltransferase-like transcripts were also significantly repressed in the midgut of both Cry1Ab and Cry1Ac resistant O. The statistics for t[r] ...
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Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro
... accumulation of bilirubin to toxic levels in patients with Crigler-Najjar type 1 (CN-I). Genetic and biochemical criteria are required to link CN-I with mutations in UGT1. Here we present analysis of mutations at the ...
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UDP 4 Keto 6 Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP Galactopyranose Mutase
... of UDP-rhamnose production in B. cinerea (10). The first enzyme (UDP-glucose-4,6-dehydratase [DH]) converts UDP- glucose to produce the intermediate metabolite UDP-KDG, which is quickly ...
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Thesis.pdf
... to UDP-glucose with final concentrations of either 5 mM or 10 ...the UDP-glucose product using high performance liquid chromatography (HPLC) to separate the individual components of the ...
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networkprotocol.doc
... UDP ws-tel:microsoft-ds *:* UDP ws-tel:1027 *:* UDP ws-tel:1034 *:* UDP ws-tel:3456 *:* UDP ws-tel:3864 *:* UDP ws-tel:netbios-ns *:* UDP ws-tel:netbios-dgm *:* ...
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Discovery of the Elusive UDP Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis
... of UDP-2,3-diacyl-GlcN (UDP-DAGn) to form lipid X is carried out by two unrelated enzymes: LpxH in beta- and gammaproteobacteria and LpxI in ...the UDP-DAGn hydrolase function in ...of ...
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UGE1 and UGE2 Regulate the UDP-Glucose/UDP-Galactose Equilibrium in Cryptococcus neoformans
... for UDP-galactose or UDP-glucose at different tem- ...on UDP-galactose (Fig. 7B). The recombinant Uge1p converted UDP-galactose to UDP-glucose, but the affinity of the enzyme was ...
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Prolonged Unconjugated Hyperbilirubinemia Associated With Breast Milk and Mutations of the Bilirubin Uridine Diphosphate- Glucuronosyltransferase Gene
... ABSTRACT. Objective. Breast milk jaundice is a com- mon problem in nursing infants. It has been ascribed to various breast milk substances, but the component or combination of components that is responsible re- mains ...
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INTERNET SECURITY USING IPTABLE
... In UDP Flood attack attacker sends large number of UDP packets to a victim system, due to which there is saturation of the network and the depletion of available bandwidth for legitimate service requests to ...
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The search for the gene mutations underlying enterotoxigenic Escherichia coli F4ab/ac susceptibility in pigs: a review
... ACK1: Activated CDC42 kinase 1; B3GALT3: UDP-Gal, β -GlcNAc- β -1,3-galactosyl transferase 3; B3GnT5: UDP-GlcNAc: β -Gal- β -1,3-N-acetylglucosaminyl transferase 5; B4GALT4: UDP-Gal: β -[r] ...
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