Uremic toxins
Hepatic Drug Metabolism, Uremic Toxins and Bacterial Composition Over Chronic Kidney Disease Progression
... of uremic toxins where mechanistic studies currently suggest a wide array of pathways from pre-transcriptional regulation through to direct inhibition of DMEs by uremic toxins, inflammatory ...
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Removal of uremic toxins by renal replacement therapies: a review of current progress and future perspectives
... The oral charcoal adsorbent AST-120 is known to re- duce serum levels of IS through the adsorption of indole, which is converted from dietary tryptophan in the gastrointestinal tract in non-dialysis CKD patients [53]. ...
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The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins
... by uremic toxins and/or siRNA was paralleled by the DIO1 activities, which was also confirmed by western blot, we speculated that the reduction in DIO1 function in HepG2 cells could be due to the inhibition ...
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Emodin via colonic irrigation modulates gut microbiota and reduces uremic toxins in rats with chronic kidney disease
... reduce uremic toxins for the treatment of CKD in China [19, ...the uremic toxins, including urea, creatinine and IS, preserves the renal function and help patients avoid the dialysis ...
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A Simple HPLC-MS/MS Method for Quantification of Naltrexone and 6-beta Naltrexol: An Application to Effect of Uremic Toxins on Metabolic Reduction
... that uremic toxins accumulated in the serum of kidney disease patients are implicated in this ...various uremic tox- ins at 10 and 100 µM on naltrexone ...
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Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins
... a uremic plasma ultrafiltrate resulted in a loss of > 50% of the binding sites for the osteocalcin ...the uremic ultrafiltrate was due to a specific interaction with the VDR, not retinoid X ...addition, ...
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Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients
... The role of indolic toxins or paracresyl-sulfate (PCS) in anemia has recently been proposed. Indoxyl sulfate (IS) and indole-3-acetic acid (IAA) are protein bound in- dolic uremic toxins derived from ...
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Prevalence of candidiasis, uremic stomatitis, uremic frost and colonization of candida subspecies in hemodialysis patients
... 34 nephrons produces erythropoietin in response to hypoxic stress, which triggers increased production of erythrocyte from the bone marrow. As kidney disease progresses (often when GFR < 30 mL/min/1.73 m2), ...
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Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study
... of uremic toxins such as indoxyl sulfate and p-cresyl sulfate ...These uremic toxins, which are nor- mally excreted by the kidney via tubular secretion, are poorly cleared by dialysis ...
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Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model
... Third, uremic toxins are not limited to AGEs; thus, we cannot exclude the possibility that spironolac- tone can ameliorate endothelial dysfunction induced by uremic toxins other than ...
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Constipation in chronic kidney disease: it is time to reconsider
... with uremic plasma exhibited a blunted level of contraction from those incubated with healthy ...with uremic toxins at the con- centration encountered in ESKD ...some uremic toxins ...
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Effect of hemodialysis on left ventricular function Dissociation of changes in filling volume and in contractile state
... Prior studies of the effect of hemodialysis on left ventricular function have not distinguished between the removal of uremic toxins and the change in cardiac filling volume. To separate these effects, left ...
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The Effect of AST-120 on Hepatic Metabolism and Transport in Chronic Kidney Disease
... characteristic uremic syndrome that can specifically demarcate the condition (Depner, ...advanced uremic syndrome (Depner, ...of uremic syndrome as renal function is preserved (Meyer and Hostetter, ...
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Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease
... in uremic rats (Magnusson et ...both uremic rats and human patients with CKD and conclude that these relatively large molecules are able to undergo paracellular transport across the intestinal epithelium in ...
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A Retrograde Trafficking Inhibitor of Ricin and Shiga Like Toxins Inhibits Infection of Cells by Human and Monkey Polyomaviruses
... by toxins and polyomaviruses to effect ER ...bacterial toxins to target the ER, since ricin and Shiga-like toxins rapidly traffic to the Golgi apparatus (44), an association that has yet to be ...
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Coral venom toxins
... 1. Toxins have been characterized from four of the Anthozoa order and examples of these toxins are given in Table 1 to highlight the structural diversity, range of bioactivities and potential ...into ...
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Research and development in optical biosensors for determination of toxic environmental pollutants
... environmental toxins, such as simazine, atrazine, nonylphenol and T-2 mycotoxin were registered with the methods of surface plasmon resonance (SPR) and the recently developed total internal reflection ellipsometry ...
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The anemia of chronic renal failure in sheep Response to erythropoietin rich plasma in vivo
... in uremic and normal sheep, regardless of the degree of ...Nondialyzed uremic sheep responded as well as dialyzed ...the uremic dialyzed animals. The anemia was corrected in the uremic sheep ...
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Binding of NAD+ Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus
... both toxins are present; derivatives with a deletion in either toxin, in both in vitro and in vivo models, are less cytotoxic (4–7, 16, 22, ...two toxins appears to be critical for pathogenesis, the ...
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Toxins and drug discovery
... of toxins into medicines began in the 1940s with the introduction of tubocurarine into anaesthetic practice as a selectively acting muscle relaxant (Bowman, ...other toxins that could cause ...
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