β-lactamases
Prevalence and molecular characterization of β lactamases in clinical isolates of klebsiella pneumoniae from north of palestine
... of β-lactamase genes in single isolates was observed in this ...of β- lactamase classes or multiple genes of ESBLs, MBLs or AmpC β-lactamases has been reported from different species of ...
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Molecular Characteristics of Extended Spectrum β Lactamases in Escherichia coli and Klebsiella pneumoniae and the Prevalence of qnr in Extended Spectrum β Lactamase Isolates in a Tertiary Care Hospital in Korea
... spectrum β -lactamases (ESBLs) are cephalosporinases that confer resistance to a wide variety of oxyimino cephalosporins and create serious therapeutic ...
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Phylogenetic typing and detection of extended-spectrum β-lactamases in Escherichia coli isolates from broiler chickens in Ahvaz, Iran
... data correlating β-lactamases in commensal and pathogenic E. coli strains from animal origin in Iran are limited. Therefore, this study was carried out to determine the phylogenetic background, to establish ...
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Assessment of extended-spectrum β-lactamases and integrons among Enterobacteriaceae in device-associated infections: multicenter study in north of Iran
... as the most common cause of extended-spectrum β- lactamases (ESBL) producing bacteria in ICUs. These bacteria have a plethora of resistance mechanisms and often use multiple mechanisms against the same ...
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DETECTION CTX M TYPES EXTENDED SPECTRUM β LACTAMASES (ESBLs) IN ESCHERICHIA COLI ISOLATION FROM PREGNANT URINARY TRACT INFECTIONS (UTIs) IN BASRA, PROVINCE, IRAQ
... TEM and SHV are most widespread ESBLs, but strains expressing CTX-M ESBLs have initiate to emerge in many countries. [12,11] The non-TEM, non-SHV most frequent ESBLs type, β-lactamases CTX-M type are ...
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Antibiotic susceptibility profile and extended spectrum β-lactamases production by uropathogenic Escherichia coli from tertiary care hospital of rural settings
... Antibiotic susceptibility profile and extended spectrum β-lactamases production by uropathogenic Escherichia coli from tertiary care hospital of rural settings.[r] ...
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Metallo β Lactamases: A Major Threat to Human Health
... Antibiotic resistance is one of the most significant challenges facing global healthcare. Since the 1940s, antibiotics have been used to fight infections, initially with penicillin and subsequently with various ...
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High levels multi-resistance to antibiotics among extended-spectrum β-lactamases-producing Enterobacteriaceae from Northwest Morocco
... spectrum β-lactamases (ESBL) producing Enterobacteriaceae are increased worldwide and are often associated with amplified morbidity and ...families. β-lactam groups are most concerned with values ...
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Identification and preliminary characterization of novel B3 type metallo β lactamases
... Antibiotic resistance has emerged as a major global threat to human health. Among the strategies em- ployed by pathogens to acquire resistance the use of metallo-β-lactamases (MBLs), a family of dinuclear ...
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The Mechanisms of Catalysis by Metallo β Lactamases
... B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and ...the ...
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Bench to bedside review: The role of β lactamases in antibiotic resistant Gram negative infections
... Group 1/Class C cephalosporinases are among the most abundant β-lactamases on the basis of the number of organisms that produce these enzymes. Th ese cephalo- sporinases, frequently named as species-specifi ...
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Detection of metallo β lactamases encoding genes among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital, Kathmandu, Nepal
... Among various mechanism of resistance for carbape- nem in P. aeruginosa, production of MBLs is of particular concern because of their rapid spread, potent carbap- enemase activity, resistance to β-lactamase ...
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Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates
... The -Lactam antibiotics represent the most successful dug class for treatment of bacterial infections. Resistance to them, importantly via production of -lactamases, which collectively are able to hydrolyse all ...
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Intrinsic Class D β Lactamases of Clostridium difficile
... Combined, our experiments showed that C. difficile strains produce intrinsic broad- spectrum CDD  -lactamases. In the two studied strains, the enzymes are poorly expressed and responsible only partially for the ...
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βlasEN: Microdilution Panel for Identifying β Lactamases Present in Isolates of Enterobacteriaceae
... A dried investigational use-only microdilution panel named  lasEN (a short named derived from the panel’s purpose, to identify  -lactamases in Enterobacteriaceae) containing 10  -lactam drugs with and without  ...
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Phenotypic Screening of Carbapenemases and Associated β Lactamases in Carbapenem Resistant Enterobacteriaceae
... Dissemination of carbapenem resistance among Enterobacteriaceae poses a considerable threat to public health. Carbapenemase gene detection by molecular methods is the gold standard but is available in only a few ...
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Using Nucleic Acid Microarrays To Perform Molecular Epidemiology and Detect Novel β Lactamases: a Snapshot of Extended Spectrum β Lactamases throughout the World
... Conclusions. Microarray combined with PCR-sequencing ap- pears to be an efficient strategy for examining quickly the molec- ular epidemiology of resistance genes, especially where large col- lections of isolates require ...
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Prevalence of CTX M β Lactamases in Philadelphia, Pennsylvania
... CTX-M  -lactamases were thought to be rare in the United States, but a recent study in Texas showed that up to 70% of extended-spectrum  -lactamase (ESBL)-containing members of the Enterobacteriaceae family were ...
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Genome sequence of Lysobacter dokdonensis DS-58T, a gliding bacterium isolated from soil in Dokdo, Korea
... 17 β-lactamases for degrading chemicals such as β-lactam antibiotics, biotin-biosynthetic pro- teins, and type IV fimbrial biogenesis proteins that could be involved in gliding motility were ...
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Key words
... The susceptibility test data showed that the ESBL-positive isolates (donors) were multiresist- ant strains, displaying resistance to most β-lactams and non-β-lactams. It should be emphasized that these ...
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