v-Src
Suppression of v-src Transformation by the drs Gene
... The v-src gene also positively or negatively alters the expression of many cellular genes (1, 6, 12, 14, 16, 28, 33, 40, 44, 45, ...by v-src have been shown to function as tumor suppressor ...
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Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.
... 11 Autophosphorylation Is Required for High Kinase Activity and Efficient Transformation Ability of Proteins Encoded by Host Range Alleles of v-src KATHLEEN M.. VERDERAMEl12* Cell and Mo[r] ...
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Isolation of Transformation Suppressor Genes by cDNA Subtraction: Lumican Suppresses Transformation Induced by v-src and v-K-ras
... the v-K-ras gene or MRSV containing the v-src gene and then inoculated into soft ...of v-K-ras gene expression. The band corresponding to v-K-ras mRNA was detected at ...of ...
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Tumor immunity generated in the course of regression of v-src-induced sarcomas.
... The present results, which establish that v-src-induced sarcoma growth in line TK chickens is associated with the induction of an immunity that confers protection against a subsequent sa[r] ...
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Cellular aging is a critical determinant of primary cell resistance to v-src transformation.
... to v-src ...a v-src gene after 2, 7, 14, 21, and 28 days of continuous ...to v-src ...span. v-src was capable of inducing formation of foci and growth in soft agar ...
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A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.
... 338 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The v-src oncogene of Rous sarcoma virus RSV is able to transform both avian and mammalian cells, but the mutant all[r] ...
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Expression of the pRb-Binding Regions of E1A Enables Efficient Transformation of Primary Epithelial Cells by v-src
... enhance v-src transformation of BRK ...and v-src, a plasmid express- ing v-Src was transfected alone or cotransfected with a plasmid expressing either WT or mutated E1A 12S genes ...
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JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells
... 3 v-Src-transformed CEFs with coinhibition of JunD and DAPK1 by shRNA form larger and more numerous colonies in soft ...are v-Src transformed and coinfected with the viruses ...
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Pleiotropic Action of AP-1 in v-Src-Transformed Cells
... in v-Src-transformed CEF, with apoptosis and the accumulation of lipid-rich vesicles observed in response to JunD and Fra-2 inhibition, ...that v-Src-transformed CEF are particularly sensitive ...
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A transformation-competent recombinant between v-src and Rous-associated virus RAV-1.
... 1873 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The LTR, v-src, LTR provirus, which arose by the reverse transcription and integration of src mRNA in the H-19 hams[r] ...
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Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants.
... As previously observed in the transfected rat-2 cells, mutations in the amino-terminal src-specific domain amino acids 8 to 87 did not affect the transforming capacity of v-src, while mo[r] ...
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Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.
... In the presence of the G-300-to-V mutation, this SH3 domain lesion does not affect v-Src in vitro kinase activity and cytoskeletal association, but it nonconditionally enhances cellular [r] ...
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Isolation and structural mapping of a human c-src gene homologous to the transforming gene (v-src) of Rous sarcoma virus.
... FUJITA2* Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824,' and Cancer Research Laboratory and Department of Biochemistry, University of Western Ontari[r] ...
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v-Src enhances phosphorylation at Ser-282 of the Rous sarcoma virus integrase.
... The enhanced phosphorylation of IN does not appear to be a general function of transformed cells, since enhanced phosphorylation was not detected in AMV derived from viremic chickens or [r] ...
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Host range mutants of v-src: alterations in kinase activity and substrate interactions.
... In the case of mutants SPX1, SHX13, and XD6, which contain linker insertions or small deletions within the SH2 domain, the kinase activitics of the mutant proteins, with enolase as the s[r] ...
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Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.
... 1927 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest A monoclonal antibody, R2D2, raised to the src gene product of Rous sarcoma virus was found to inhibit the tyrosine[r] ...
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Generation of recombinant murine retroviral genomes containing the v-src oncogene: isolation of a virus inducing hemangiosarcomas in the brain.
... * 5333 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest A series of recombinant retroviral genomes was generated by cotransformation of NIH 3T3 cells with a mixture of c[r] ...
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The membrane-binding domain of the Rous sarcoma virus Gag protein.
... wild-type v-src gene or the v-src-G2A allele (which encodes an unmyristylated form of Src and cannot transform cells [10]), were transfected into NIH 3T3 cells by a standard calcium ...
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Control of expression of an integrated Rous sarcoma provirus in rat cells: role of 5' genomic duplications reveals unexpected patterns of gene transcription and its regulation.
... The presence of v-src sequences in the 5' duplication flanking the RSV provirus in All cells raised the possibility that this duplicated gene, rather than the unrearranged proviral v-src[r] ...
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2519.full.pdf
... Our data indicate that (i) only a portion of c-src is represented within v-src, (ii) the leftward re- combination between the genome of the transducing virus and c- src occurred in an in[r] ...
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