VEGF-B
Dual effects of VEGF B on activating cardiomyocytes and cardiac stem cells to protect the heart against short and long term ischemia–reperfusion injury
... factor B (VEGF‑B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion (I/R) heart and promotes CSC mobilization and ...human VEGF‑B protein ...
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Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease
... factor B (VEGF-B) was evident, while vascular endothelial growth factor A (VEGF-A) levels remained ...applied VEGF-B performed as a neuroprotective agent facilitating neuron ...
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Increased CSF biomarkers of angiogenesis in Parkinson disease
... of VEGF ( b 5 0.22, p 5 0.037), PlGF ( b 5 ...( b 5 ...and VEGF as well as PlGF were similar in the PDND ...CSF VEGF (b 5 0.46, p 5 0.003) and PlGF (b 5 ...
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Ziv-aflibercept in metastatic colorectal cancer
... (VEGF)-A, VEGF-B, and placental growth factor (PlGF); it was approved in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) for the treatment of patients with metastatic colorectal ...
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Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
... The strong correlations found between the proangiogenic factors revealed that mice showing high expression of ang- iogenic growth factors VEGF-A and VEGF-B, also showed high expression of their ...
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Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells
... Although VEGF and PDGF are growth factors with multi-potentials for vascular formation, their sequential roles have not been ...of VEGF and PDGF B signals for vascular formation by a 3D culture ...
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Intrauterine growth restriction and placental angiogenesis
... factors VEGF, b-FGF, and eNOS have important roles in villous proliferation, trophoblast function, and angiogenesis as characterized by the formation of new vascular structures in the villous stroma ...
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Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels
... by VEGF-B, VEGF-C and VEGF-D ...preadipocytes, VEGF-B and VEGF-C mRNA levels are less modulated, whereas that of VEGF-A are up-regulated ...of VEGF-C and ...
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Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction
... Numerous studies have demonstrated that stimulation of angiogenesis is beneficial to ischemic and infarcted heart [34–37]. Collateral growth during ischemia requires proliferation of endothelial cells, recruitment of ...
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Review Article Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract
... members VEGF-A, VEGF-B, VEGF-C, VEGF-D, PIGF, three tyrosine kinase receptors VEGFR-1, VEGFR-2, VEGFR-3 and two non protein kinase co-receptors (neutropilin -1 and ...neutropilin-2). ...
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Key words
... decreased VEGF−A level in some patients after STEMI could be related to the anti−inflammatory effects of ...of VEGF−A not only in plasma, but also in ...of VEGF−A reflects total cytokine level ...
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Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism
... Abnormalities in cell death control contribute to a variety of diseases including cancer, autoimmunity, degenerative disorders and osteoporosis [1,2,17,23]. Signaling for apoptosis occurs through multiple independent ...
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VEGF - A Precis’
... lived VEGF mrNA is both induced and stabilized on exposure to ...of VEGF harbours a conserved OrF which can add a 180 aminoacid stretch in front of ...Long VEGF (L-VEGF). Effective cleavage of ...
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Tumor VEGF:VEGFR2 autocrine feed forward loop triggers angiogenesis in lung cancer
... the VEGF/VEGFR2/mTOR autocrine feed-forward loop enhanced ERK signaling, as a result of activation of the insulin growth fac- tor receptor (IGFR) signaling pathway via IRS-1 (Figure 4, C and ...and B, and ...
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Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis
... of VEGF receptors has not been reported in immature mesenchymal cells or ureteric bud epithelial cells (14, 15), direct effect of VEGF on those cells seems to be less ...endogenous VEGF activity, ...
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The Different Impact of VEGF-A and VEGF-D on Peritumoral Brain Edema
... both VEGF-dependent and VEGF-independent pathways of edema production in gliomas and may explain whye demais not reduced in some patients following anti-VEGF treatment ...of VEGF-A in brain ...
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1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis
... of VEGF upregulation in this model, treatment with naked VEGF-A siRNA did not relevantly inhibit tumor ...naked VEGF-A siRNA sequence achieved sig- nificant antitumoral effects in a prostate cancer ...
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Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
... driven VEGF expression following MI leads to edema and cardiac dam- ...Upon VEGF stimulation, Src activity is required for the disruption of a preformed Flk-cadherin-catenin complex, which loosens EC-cell ...
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Evaluation of the potential of a simplified co-delivery system with oligodeoxynucleotides as a drug carrier for enhanced antitumor effect
... as 100%. For lipo/siRNA group, the silencing efficiencies were 61.98% ± 6.96%, 31.93% ± 6.43% and 37.02% ± 3.17% at 24, 48 and 72 h, respectively. The decreased expression of VEGF mRNA reflected that gene ...
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Age-related macular degeneration: experimental and emerging treatments
... inhibit VEGF by using VEGF Trap. It is a recombinant soluble VEGF receptor pro- tein in which the binding domains of VEGF receptors one and two are combined with the Fc portion of ...
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