VEGF-C
Original Article Overexpression of both VEGF-A and VEGF-C in gastric cancer correlates with prognosis, and silencing of both is effective to inhibit cancer growth
... from VEGF-A-knockdown cells, VEGF-C- knockdown cells, negative control cells and SGC7901 cells, ...for VEGF-A were 5’-ATAAGTCC- TGGAGCGTGTACGTT-3’ (forward), 5’-CAGGAACA- TTT ACACGTCTGCG-3’ ...
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Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer
... Immunohistochemistry was carried out on paraffin- embedded tumor specimens fixed in 4% buffered for- malin. Four-micrometer-thick histological slides were de-paraffinized in xylol and heated in 0.01 M citrate buffer for ...
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Rapamycin reversal of VEGF-C–driven lymphatic anomalies in the respiratory tract
... Double-transgenic CCSP-rtTA/tetO-VEGF-C (CCSP/VEGF-C) mice of both sexes in a FVB/N background were generated by breeding Clara cell secretory protein reverse tetracycline transactivator ...
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VEGF C and aortic cardiomyocytes guide coronary artery stem development
... other VEGF family members could have a role during mammalian coronary development, embryos were treated with the pan-VEGFR inhibitor axitinib in ...the VEGF pathway as a poten- tial player during stem ...
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Immunohistochemical expression of vascular endothelial growth factor-c (vegf-c) in salivary gland tumours
... Salivary gland tumours constitute 1-4% of all tumours occurring in human body (11) . Among these, pleomorphic adenoma is the most commonly occurring benign salivary gland tumour in any location mostly involving the ...
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Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
... VEGF: vascular endothelial growth factor; VEGF-C: vascular endothelial growth factor-C; VEGFR-l: vascular endothelial growth factor receptor-l (Fit-I); VEGFR-2: vascular e[r] ...
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<p>Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression</p>
... tumors, VEGF-C is secreted by the tumor cells and ...to VEGF-C and VEGF-D. VEGF-C contacts with VEGFR-3, triggers the activation of intracellular down- stream signal ...
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WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
... and VEGF-C transcription factors are ...up-regulating VEGF-A and VEGF-C ...and c-Myc, the important target genes of the Wnt/ β-catenin ...and VEGF-C in ACC invasion ...
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Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation
... in VEGF-C–transgenic mice suffering from chronic inflammation has been reported before (38) and represents one possible mechanism for the fusion protein’s antiinflammatory ...K14- VEGF-C mice, ...
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Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway
... on VEGF-C- induced tube formation, we transduced a Slit2N-expressing adenovirus or a control virus into L-LECs, and observed Slit2N expression by Western blot analysis, 24 hours post- transduction (Figure ...
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VEGF C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
... of VEGF-C cDNA in the skin of transgenic mice induced lymphatic endothelial cell proliferation and hyperplasia of the lymphatic vas- culature, and recombinant VEGF-C specifically stimu- lated ...
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The Schlemm’s canal is a VEGF C/VEGFR 3–responsive lymphatic like vessel
... that VEGF-C overexpression in the anterior chamber of the eye results in the sprouting, proliferation, and mi- gration of SC ECs with a trend toward IOP ...reduction. VEGF, on the other hand, which ...
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Foxp3 is correlated with VEGF C expression and lymphangiogenesis in cervical cancer
... cases. VEGF-C is essential for most lymphangiogenic processes by activating the vascular endothelial growth factor receptors VEGFR-3 and VEGFR-2 ...of VEGF-C in lymphangiogenesis, we evaluated ...
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VEGF C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
... phatic pumping, implicating the lymphatic system as a player in various inflammatory disorders, including IBD. For this reason, we next investigated whether inhibition of lymphangiogenesis in mF431C1-treated mice is ...
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Basic fibroblast growth factor promotes VEGF-C-dependent lymphangiogenesis via inhibition of miR-381 in human chondrosarcoma cells
... on VEGF-C expression is largely ...bFGF-induced VEGF-C expression as well as LEC migration and tube ...represses VEGF-C protein expression through binding with the 3′UTR region ...
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Original Article Clinical study on the correlation between lymph node metastasis and lymphangiogenesis in colon cancer
... Colon cancer is a common clinical malignant tumor of the digestive tract [1, 2] and surgical resection is the main treatment method. How- ever, studies have found that the postoperative recurrence rate of this disease is ...
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The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer
... Results: VEGF-D produced by tumor cells has an autocrine affinity for its receptor ...regions VEGF-D-induced receptor activation by autophosphorylation at Tyr1214 seems to be a possible initial event of the ...
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Increased lymphangiogenesis in joints of mice with inflammatory arthritis
... Recently, VEGF-C or VEGFR-3 antagonists have been used to directly stimulate or block VEGF-C/VEGFR-3-mediated lymphangiogenesis in sev- eral models of ...by VEGF-C antagonism ...
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Molecular Properties of Lymph Node Micrometastasis as an Important Therapeutic Target in Gastric Cancer
... of VEGF-C and VEGF-D was identified in ...of VEGF-C and VEGF-D expression demonstrated that the expression levels of VEGF-C and -D were significantly correlated ...
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Review Article Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract
... members VEGF-A, VEGF-B, VEGF-C, VEGF-D, PIGF, three tyrosine kinase receptors VEGFR-1, VEGFR-2, VEGFR-3 and two non protein kinase co-receptors (neutropilin -1 and ...neutropilin-2). ...
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