ventral midbrain
Regulation of ventral midbrain patterning by Hedgehog signaling
... the ventral midbrain and that this requirement was extinguished by H&H stage 13 (Figs 1, ...dorsal midbrain by HH is a measure of the range of HH signaling (Ericson et ...the ventral limit ...
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Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
... of midbrain dopamine neurons (DNs) have intensified research aimed at deciphering developmental programs controlling midbrain ...the ventral midbrain can be subdivided into molecularly ...
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Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
... (Shh-responding) ventral mesencephalic precursors shifts laterally over time Gli1 is initially expressed in the ventral midline of the neural tube at ...the ventral mesencephalic neural tube receives ...
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Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain
... and ventral midbrain as expected by the lack of Otx2 in these ...the ventral midbrain, such as lack of RN neurons, hypoplasia of the oculomotor nucleus (OM) ...
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Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
... the ventral midbrain, where mesencephalic dopaminergic neurons are ...the ventral midline, while Ngn1, Ngn2 and Mash1 are co-localized more laterally in the ventricular ...
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Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
... developing ventral midbrain (vMB) defined by a combinatorial code of transcription ...the ventral spinal cord, Olig2 and Pax6 were not detected in vMB at ...
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Transcriptional control of early tract formation in the embryonic chick midbrain
... same ventral cluster at the midbrain- forebrain border (MFB) (Tallafuss et ...the ventral midbrain of chick embryos between HH15 and HH25, when the early axon scaffold is ...the ventral ...
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The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons
... of ventral midbrain tissue has been previously described ...dissected ventral mid- brains were homogenized, the RNA isolated using the RNeasy Mini kit (Qiagen group, USA) and reverse- transcribed ...
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A Wnt1 regulated genetic network controls the identity and fate of midbrain dopaminergic progenitors in vivo
... mutant midbrain (Puelles et al., 2003). However, loss of Otx2 in the midbrain FP and BP of En1 +/Cre ; Otx2 flox/flox embryos leads to a ventral expansion of the midbrain Nkx2-2 domain and to ...
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Blocking meningeal lymphatic drainage aggravates Parkinson’s disease like pathology in mice overexpressing mutated α synuclein
... AQP4 is highly localized to perivascular endfeet, which is necessary for glymphatic solute transport in rodent brains [38–40]. Several studies from independent groups have confirmed that reactive astrogliosis causes loss ...
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Derivation of human midbrain-specific organoids from neuroepithelial Stem Cells
... of midbrain dopaminergic neurons ...the midbrain-specific transcription factor OTX2 (Figure 2E) and the mDN marker TH (Figure ...the ventral marker NKX6-1 (Figures 2F and ...toward ventral ...
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Melatonin action in a midbrain vocal acoustic network
... Male plainfin midshipman (Porichthys notatus) (Girard, 1854) contract sonic swim bladder muscles at ~100 Hz to produce several call types distinguishable mainly by their duration and the social context under which they ...
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Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates
... the ventral body wall and in closure of the neural tube, and either an arrest of embryonic turning and heart looping or a randomisation in their direction ...
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The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg
... or ventral fate. One solution would be the ventral- or dorsal-specific expression of a selector gene downstream of Wg and Dpp ...the ventral-specific expression of H15 and midline downstream of Wg ...
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Transcriptional control of midbrain dopaminergic neuron development
... dorsal midbrain progenitors into DA neurons (Kele et ...of midbrain progenitors into mDA neurons, and will also lead to the discovery of downstream components of these regulatory ...the midbrain and ...
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Genome wide analysis of facial skeletal regionalization in zebrafish
... of ventral (V) to intermediate (I) domains, as well as some dorsal (D) domain CNCCs and the otic vesicle; and hand2:GFP and sox10:DsRed in ventral and more weakly in ventral-intermediate (VI) CNCCs ...
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The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds
... The results were evaluated using the Affymetrix Expression Console and MAS5 algorithm. As we had only two replicates for each sample (too small a number to use methods based on analysis of variance or integral methods, ...
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A Clinical study on Ventral Hernias
... It is the smallest of the three flat muscles and originate from lower five ribs, the Thoracolumbar fascia, the internal lip of iliac crest, and the lateral third of the inguinal ligament. The direction of its fibers is ...
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Development of the nervous system in Solenogastres (Mollusca) reveals putative ancestral spiralian features
... the ventral nervous system, which consists of one pair of neurite bundles and a ven- tromedian, unpaired nerve plexus, and the cerebral com- missure at the base of the apical organ have ...
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Midbrain Hindbrain Involvement in Septo Optic Dysplasia
... MH abnormalities are a significant, albeit under-recognized, component of the SOD spectrum. We demonstrated that the pons, medulla, and vermis were significantly hypoplastic in more than 50% of patients with SOD. ...
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