Viral mechanisms interfering with antigen processing and
Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... altered antigen presentation, and indeed, the major peptide supplier to the ER, TAP, has been shown to be the target of a number of different ...cient antigen presentation is ...for viral ...
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Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
... II processing pathways are to date poorly characterized at the cell biological ...II processing of the nuclear antigen 1 (EBNA1) of the Epstein-Barr virus ...latent antigen for CD4 + T cells ...
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An Avian Retrovirus Uses Canonical Expression and Processing Mechanisms To Generate Viral MicroRNA
... DISCUSSION Of the 295 virus-encoded miRNAs deposited in the miRBase da- tabase, the vast majority are encoded by DNA viruses. The small size and lack of immunogenicity, combined with the ability for specific repression ...
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Catheptic antigen processing
... the antigen must first be internalized and degraded into fragments by an antigen presenting ...as viral proteins, are predominantly presented by MHC class I molecules, which can be expressed on ...
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The Efficacy of Antigen Processing Is Critical for Protection against Cytomegalovirus Disease in the Presence of Viral Immune Evasion Proteins
... Cytomegaloviruses (CMVs) code for immunoevasins, glycoproteins that are specifically dedicated to inter- fere with the presentation of antigenic peptides to CD8 T cells. Nonetheless, the biological outcome is not an ...
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Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells
... epigenetic mechanisms that are likely to be involved in the expression of key genes in spermatogonia, namely Pou5f1 and ...molecular mechanisms revealed by pharmacological treatments of the GC-1 cell line ...
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Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing
... pleiotropic mechanisms of action and were suggested as po- tential adjunct therapy for Ebola virus disease (EVD) during the 2013–2016 outbreak in West ...with viral entry, but the viral particles ...
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Antigen Processing and Presentation; Direct and Cross
... the active proteolytic subunits. Proteins are introduced into core of the proteasome for degradation then released. Three subunits of the proteasome called LMP2, LMP7 and MECL-1 are induced by interferons following ...
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The Viral Latency-Associated Nuclear Antigen Augments the B-Cell Response to Antigen In Vivo
... molecular mechanisms by which KSHV latent genes, such as LANA, lead to B-cell hyperplasia, such as MCD, or frank DLBCL, such as PEL, are poorly ...of mechanisms have been proposed for LANA-dependent cell ...
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Kinetics of protective antibodies are determined by the viral surface antigen
... underlying mechanisms in 2 widely studied viral infection mod- ...the viral surface GP and not by the virus ...the viral GP determines nAb kinetics largely independently of the specific ...
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Multiple Viral Ligands Naturally Presented by Different Class I Molecules in Transporter Antigen Processing-Deficient Vaccinia Virus-Infected Cells
... with antigen processing (TAP) delivers the viral proteolytic products generated by the proteasome in the cytosol to the endoplasmic reticulum lumen that are subsequently recognized by cytotoxic T ...
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Bovine viral diarrhea virus: characterization of a cytopathogenic defective interfering particle with two internal deletions.
... However, it has been reported for HCV that detection of the effects of truncations depends on the assay system and the processing site analyzed (4). Moreover, processing at the two sites analyzed here ...
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Antigen Processing
... Antig tigen en pro proces cessin sing g re refer fers s to to the abili the ability ty of of and APCs and APCs to to bre break ak dow down n a a pro protei tein n ant antige igen n in into to pept peptides and to assoc ...
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Mechanisms of viral emergence
... of viral vectors (arthro- pods, birds, ...a viral disease, once it has ...for viral surveillance have greatly improved our knowledge of the factors that underlie the emergence and re-emergence of ...
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The enzymology of antigen processing
... Cat hep si n B D and E were shown to degrade HEL during cell free digests pe r fo r m ed un der various condit ions. The di ffer ences in the enzy mati c spe ci fic it ie s of each enzyme towards HEL are ev ide nt from f ...
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Molecular Bases of Viral RNA Targeting by Viral Small Interfering RNA-Programmed RISC
... Comparison of the level of virus-derived siRNAs specific for the cleavage hot spot with the siRNA level specific for a non- targeted region did not show any difference. Thus, we hypoth- esized that the presence of a hot ...
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Defective Interfering Particles of Poliovirus IV. Mechanisms of Enrichment
... Hyperenrichment was observed in labeled virus produced shortly after addition of labeled uridine, in the progeny from infected cells which were shifted to temperatures below 37 C at 150 [r] ...
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Interfering with feedback processing: Implications for decision making and learning
... 1.1. Economic models for reward and punishment processing 1.1.1. Expected utility theory According to the expected utility theory a decision within an uncertain environment relies on a comparison between expected ...
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Antigen processing pathways in transplantation
... Lechler and Batchelor used results from studies of specific HLA-DR primed T-cell clones to propose that an allo-MHC can be thought of as having two functional sites (Lechler et al. 1991; Lechler et al. 1990; Lombardi et ...
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Cyclophilin Inhibitors Block Arterivirus Replication by Interfering with Viral RNA Synthesis
... prevented viral RNA and protein synthesis in EAV-infected cells, and CsA treatment resulted in a ...isolated viral replication structures. The small interfering RNA-mediated knockdown of Cyp family ...
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