Virus Replication
Network Guided Discovery of Influenza Virus Replication Host Factors
... influenza virus proteins are central to the PPI ...of virus-interacting and non-virus-interacting host ...influenza virus proteins (viral PB2, PB1, PA, HA, NP, NA, M1, M2, NS1, NS2, and PB1-F2 ...
14
miR 124 attenuates Japanese encephalitis virus replication by targeting DNM2
... miRNAs regulate many biological processes by interact- ing with their target genes. Host miRNAs were previously shown to directly target viral genomic RNAs; for example, miR-122 facilitates hepatitis C virus ...
10
DMO CAP inhibits influenza virus replication by activating heme oxygenase 1 mediated IFN response
... regulating virus replication by inhibiting oxidative stress and inflammation [38, ...influenza virus activity in this ...IAV replication at least in part by up-regulating the expression of ...
9
Muscovy duck reovirus σNS protein triggers autophagy enhancing virus replication
... To determine the effects of MDRV-induced autophagy on virus replication, DF-1 cells were plated in 6-cm cell culture dishes. Cells were infected with MDRV at an MOI of 1 for 24 h. In rapamycin, chloroquine, ...
10
Quinic acid derivatives inhibit dengue virus replication in vitro
... dengue virus replication (RepDV1 and ...dengue virus replication only for serotype-3 (RepDV3), not showing any effect against replication of dengue virus serotype-1 ...dengue ...
13
C terminal region of apoptin affects chicken anemia virus replication and virulence
... The animal experiments were performed in strict com- pliance with the Guideline for the Care and Use of Laboratory Animals of the Ministry of Science and Technology of the People’s Republic of China. The ani- mal ...
10
Cirsimaritin inhibits influenza A virus replication by downregulating the NF κB signal transduction pathway
... A major host signaling pathway implicated in in- fluenza virus replication is the NF-κB pathway. IAV infection has been shown to activate the NF- κ B pathway [7]. In most cells, NF-κB exists as an in- ...
9
COS 7 based model: methodological approach to study John Cunningham virus replication cycle
... Our model could be used to try to study one of the unresolved question regarding the ability of archetype JCV NCCR to mutate. In fact the NCCR is the highest variable sequence in the JCV genome. The mechanisms, through ...
6
Inhibition of protein kinase C promotes dengue virus replication
... Methods: In silico analyses in conjunction with in vitro kinase assay were used to study kinases that potentially phosphorylate DENV NS5. Potential kinase was inhibited or activated by a specific inhibitor (or siRNA), or ...
13
Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy
... Influenza A viruses are enveloped negative-stranded RNA viruses of the Orthomyxo- viridae family that possess segmented genomes. Each ribonucleoprotein (RNP) complex of an influenza virion consists of an RNA strand ...
18
DNA Virus Replication Compartments
... the virus is not associated with these nuclear ...EBV replication immedi- ately disrupts PML-NBs by dispersing Sp100, Daxx, and ...to replication compartments and in- teracting with the EBV DNA ...
17
Interferon lambda inhibits dengue virus replication in epithelial cells
... DENV replication and its interaction with the innate response led by ...DENV-2 replication in a dose-dependent ...viral replication inhibition by exogenous IFN-λ1 was also observed, although at ...
14
Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model
... influenza virus-induced mortality and ALI in mice [10, ...influenza virus-induced ALI in mice infected with HPAI H5N1 and H9N2 without affecting the virus replication [9, ...influenza ...
13
Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... immunodeficiency virus type 1 (HIV-1) ...influence virus mutant ...on virus mutant frequencies resulted in different mutant frequency ...when virus replication occurred in the presence ...
10
Multicomponent origin of cytomegalovirus lytic-phase DNA replication.
... Described herpesvirus replication origins vary in their structure and function; alphaherpesvirus e.g., herpes simplex virus and varicella-zoster virus replication origins consist of a si[r] ...
7
The Capsid-Binding Nucleolar Helicase DDX56 Is Important for Infectivity of West Nile Virus
... to virus replication cannot usually be discerned by these ...this virus protein has been implicated in a variety of processes that may contribute to pathogenesis, including in- duction of apoptosis ...
10
Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of Herpes Simplex Virus and Human Immunodeficiency Virus Type 1 by Targeting Cellular, Not Viral, Proteins
... block replication of several viruses, in- cluding herpes simplex virus type 1 (HSV-1) and human immunodeficiency virus type 1 ...DNA replication proteins, or proteins involved in nucleotide ...
9
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro
... A virus, Viperin targeted lipid rafts to interfere virus re- lease from the plasma membrane of infected cells ...influence virus release. And virus binding/entry examination indicated the ...
11
Inhibition of Virus DNA Replication by Artificial Zinc Finger Proteins
... of virus infections in both agricultural crops and humans have been vigorously sought for a long ...DNA virus replication is well con- served among plants and mammals ...the replication origin ...
6
Replication of Murine Cytomegalovirus in Differentiated Macrophages as a Determinant of Viral Pathogenesis
... the virus and the ...MCMV replication, are target cells for MCMV infection within tissues, and harbor latent MCMV ...MCMV replication in macrophages positively correlates with virulence in ...
11