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Voltage-gated proton channel

pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1

pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1

... the channel was not discovered until 2006 when two groups cloned human and murine HVCN1 genes [8,9], which prompted a wave of new studies on voltage-gated proton channel function and ...

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Perspective The gp91 phox Component of NADPH Oxidase Is Not a Voltage-gated Proton Channel

Perspective The gp91 phox Component of NADPH Oxidase Is Not a Voltage-gated Proton Channel

... H channel properties change during activation of NADPH oxidase; there is one channel with two gating ...of voltage-gated proton channels are radically different than in cells studied ...

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Voltage-gated proton channel in a dino agellate

Voltage-gated proton channel in a dino agellate

... gated proton channels in 1972 in bioluminescent dinoflagellates, where they were thought to trigger the fl ash by activating ...luciferase. Proton channel genes were subsequently identi fi ed in ...

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Consequences of Dimerization of the Voltage-Gated Proton Channel

Consequences of Dimerization of the Voltage-Gated Proton Channel

... tetrameric channel, crossed most of the membrane electrical ...(a) channel opening before all the VSDs have moved and (b) tran- sitions between open ...BK channel, whose g–V relationship at ...

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Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hH 1

Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hH 1

... produce proton-selective conduction without requiring contribution from the rest of the protein beyond providing a scaffold and focusing aqueous access to the selectivity filter (Dudev et ...to ...

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Construction and validation of a homology model of the human voltage-gated proton channel hH 1

Construction and validation of a homology model of the human voltage-gated proton channel hH 1

... Specifically, we examine the conformational fluctua- tions of residues located at the narrowest part of the channel (Fig. 7) and the time-averaged probability dis- tribution of water along the mean axis of the ...

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The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma Thomas E. DeCoursey

The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma Thomas E. DeCoursey

... tetrameric voltage-gated ion channels (Figure 1) whose four VSDs surround a single central pore and all contribute to prying it ...a voltage-induced conformational change before either conduction ...

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Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hH 1

Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hH 1

... the channel conserved, but there was also no significant axial displacement of individual helices in response to any of the mutations, and the plasticity of the channel with respect to axial helix movement ...

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Biophysical properties of the voltage-gated proton channel H 1 Boris Musset and Thomas DeCoursey

Biophysical properties of the voltage-gated proton channel H 1 Boris Musset and Thomas DeCoursey

... in the nonconducting C15orf27. Only one of those mutations (D112V) abolished proton current. This position was mutated further into basic, acidic, and neutral residues. The reversal potential was measured in seven ...

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Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

... where proton channels sus- tain B-cell receptor (BCR) signaling via regulation of reactive oxygen species production by the NADPH oxidase enzyme com- plex ...cells, proton channels prevent excessive ...

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Selectivity Mechanism of the Voltage-gated Proton Channel, H V

Selectivity Mechanism of the Voltage-gated Proton Channel, H V

... Although the interactions between ions and the known SF ligands (notably, both amino acids directly implicated in selectivity by mutation studies) have been treated in detail using all-electron quantum mechanical ...

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Detailed comparison of expressed and native voltage-gated proton channel currents

Detailed comparison of expressed and native voltage-gated proton channel currents

... human proton channel was expressed in HEK-293 cells (downward green triangles), the mouse channel in COS-7 cells ...Native proton currents are from other studies in THP-1 cells (upward ...

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Aspartate 112 is the selectivity filter of the human voltage-gated proton channel

Aspartate 112 is the selectivity filter of the human voltage-gated proton channel

... The Cl – permeability of D112H was completely unexpected, given strong precedents for His imparting proton selectivity to channels. Histidine shuttles protons in K 1 or Na 1 channel VSDs with ArgRHis ...

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Philosophy of voltage-gated proton channels

Philosophy of voltage-gated proton channels

... the proton channel adopts two functional con- ...each channel allows up to 10 5 H þ to cross the membrane per second but when they are ‘closed’, they do not allow any ions to cross the ...A ...

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VOLTAGE-GATED PROTON CHANNELS: MOLECULAR BIOLOGY, PHYSIOLOGY, AND PATHOPHYSIOLOGY OF THE H V

VOLTAGE-GATED PROTON CHANNELS: MOLECULAR BIOLOGY, PHYSIOLOGY, AND PATHOPHYSIOLOGY OF THE H V

... a voltage-gated proton channel (207) and contradictory evidence was presented, is recounted in detail elsewhere ...authentic proton channel genes were identified in human (416), ...

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Voltage-gated proton channels in microglia

Voltage-gated proton channels in microglia

... closed channel to open, but rather a measure of the average time spent by each channel in the closed state before it randomly ...each channel on average stays open before it ...In voltage ...

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Abstract: Voltage-gated proton channels are highly proton selective ion channels that are present in many cells. Although their unitary

Abstract: Voltage-gated proton channels are highly proton selective ion channels that are present in many cells. Although their unitary

... Voltage-gated proton channels recently left the ranks of a shrinking number of ion channels whose genetic and molecular identity is ...of voltage-gated proton ...human ...

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Voltage-gated proton channels: what’s next?

Voltage-gated proton channels: what’s next?

... mouse channel, mVSOP, with either HA or Myc, co-expressed the two constructs and then fished with antibodies to the ...the proton channel comprised multimers that contain both ...intestinalis ...

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Voltage-Gated Proton Channels and Other Proton Transfer Pathways

Voltage-Gated Proton Channels and Other Proton Transfer Pathways

... channel is a molecular entity distinct from any known NADPH oxidase component. Although much progress has been made, the most exciting discoveries lie in the future. I thank Vladimir V. Cherny for nearly a decade ...

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A RT I C L E The Antibacterial Activity of Human Neutrophils and Eosinophils Requires Proton Channels but Not BK Channels

A RT I C L E The Antibacterial Activity of Human Neutrophils and Eosinophils Requires Proton Channels but Not BK Channels

... observe voltage- gated proton channels and have never seen evidence of BK channels in human neutrophils or eosinophils, whereas Ahluwalia et ...ion channel expression refl ect donor ...lacked ...

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