von Willebrand factor A
Thrombin induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets
... concentration-dependent binding of 125I-labeled F. VIIIVWF in a steady-state system. The binding induced by thrombin was specific because it was inhibited by a 100-fold molar excess of unlabeled F. VIIIVWF factor, ...
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Intracellular trafficking of factor VIII to von Willebrand factor storage granules
... plasma, von Willebrand factor (vWf) associates with Factor VIII (FVIII); however, the site at which these pro- teins first interact has not been ...
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Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A
... centrates represent the product of choice in children. The development of IgG alloantibodies (inhibitors) directed against FVIII, neutralizing its activity by a rapid clearance of infused FVIII and resulting in a marked ...
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Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease
... At inclusion in the study, plasma levels of VWF:Ag, VWF col- lagen binding capacity (VWF:CB), VWF activity (measured by the VWF monoclonal antibody assay; VWF:Ab) and FVIII coagulant activity (FVIII:C) were centrally ...
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Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin Role of platelet activation, fibrinogen, and two distinct membrane receptors
... purified von Willebrand factor (vWF), obtained from unrelated patients affected by type IIB von Willebrand disease, were found to have normal sialic acid content (between 129 and 170 ...
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Elevated coagulation factor levels affect the tissue factor-threshold in thrombin generation
... Hemostasis is tightly regulated by pro- and anticoagulant pathways. Any irregularity in these regulatory pathways may shift the balance to a hypercoagulable state, which in turn could lead to venous thromboembolism ...
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von Willebrand factor binds to platelets and induces aggregation in platelet type but not type IIB von Willebrand disease
... Platelet-type von Willebrand disease (vWD) and pseudo-vWD are two recently described intrinsic platelet defects characterized by enhanced ristocetin-induced agglutination in platelet-rich ...a von ...
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Genetic Variations in Exon 3 of VWF Gene in Patients with Von Willebrand Disease (VWD) from South-West Iran
... Von Willebrand disease (VWD) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population ...in Von Willebrand Factor (VWF) which is a glycoprotein with ...
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Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... chromatography and 4% agarose gel filtration was subjected to sodium dodecyl sulfate gel electrophoresis on gels containing 2% acrylamide and 0.5% agarose. We find a series of multimers of which the apparent molecular ...
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Carbohydrate of the Factor VIII/von Willebrand Factor in von Willebrand's Disease
... plasma Factor VIII/von Willebrand factor (FVIII/vWF) molecule from 16 patients with von Willebrand's disease, and have found no evidence of a significant decrease of carbohydrate ...
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Functional domains on von Willebrand factor Recognition of discrete tryptic fragments by monoclonal antibodies that inhibit interaction of von Willebrand factor with platelets and with collagen
... the von Willebrand factor (VWF) moiety of the Factor VIII-von Willebrand factor complex (FVIII-VWF), one interacting with blood platelets, and one interacting with vessel ...
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Inactivation of human factor VIII by activated protein C Cofactor activity of protein S and protective effect of von Willebrand factor
... endogenous von Willebrand factor, resulting in a complete protection against APC (4 ...severe von Willebrand's disease, we could vary the amount of von Willebrand ...of ...
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Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor
... von Willebrand factor (vWF) is a large, multimeric glycoprotein that helps platelets adhere to vascular subendothelium. Although vWF binding to platelet receptors and connective tissue constituents ...
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Correction of a dominant-negative von Willebrand factor multimerization defect by small interfering RNA-mediated allele-specific inhibition of mutant von Willebrand factor
... VWF-HA and VWF-MYC protein and mRNA levels were normalized to the VWF-HA and VWF-MYC protein and mRNA levels measured in HEK293 cells co-transfected with the two VWF alleles and siNEG [r] ...
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Heritability of plasma concentrations of clotting factors and measures of a prethrombotic state in a protein C-deficient family
... prothrombin, factor (F)V, factor VIII, factor (F)IX, ®brinogen, von Willebrand factor (VWF), antithrombin, protein C, protein S, protein Z, protein Z-dependent protease inhibitor ...
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... the von Willebrand factor is a biomarker of endothelial ...dysfunction. Von Willebrand fac- tor is primarily synthesized in endothelial cells and released into circulation when ...
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Salvage therapy with high dose Intravenous Immunoglobulins in acquired Von Willebrand Syndrome and unresponsive severe intestinal bleeding
... Von Willebrand factor (VWF) is an adhesive glycopro- tein synthesized by endothelial cells and megacaryocytes and released through a regulated pathway after storage in endothelial Weibel-Palade ...
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Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC)
... of von Willebrand's disease has been identified in which sodium dodecyl sulfate agarose electrophoresis provides evidence that the von Willebrand factor present is structurally ...
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Binding of Staphylococcus aureus Protein A to von Willebrand Factor Is Regulated by Mechanical Force
... ABSTRACT Binding of Staphylococcus aureus to the large plasma glycoprotein von Willebrand factor (vWF) is controlled by hydrodynamic flow conditions. Currently, we know little about the molecular ...
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von Willebrand factor
... risk factor for recurrent myocardial infarction and death ...severe von Willebrand disease, who have mark- edly reduced levels of vWF, are protected from developing aortic plaques even when fed a ...
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