Wnt/β-catenin signalling
Activation of Wnt/β-catenin signalling promotes mesenchymal stem cells to repair injured alveolar epithelium induced by lipopolysaccharide in mice
... of Wnt/β-catenin signalling may be involved in the pulmonary ...of Wnt/β-catenin signalling in AT II cells has been linked to the pathogenesis of pul- monary ...of ...
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Wnt/β-catenin signalling is necessary for gut differentiation in a marine annelid, Platynereis dumerilii
... the Wnt/β-catenin pathway from 5 to 7 dpf does affect the expression of the Wnt target gene Pdu-Axin, but not dramatically, although reported to be the case at 55 dpf [46], which may be ...
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The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5
... canonical Wnt/ β -catenin signalling observed in the ciliopathy disease ...canonical Wnt signalling following loss of TMEM67 is dependent on ...canonical Wnt/ β ...
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Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
... The Wnt/ β -catenin pathway plays critical roles in regulating embryonic development and physiological ...of Wnt ligands, β -catenin is degraded by a destruction ...a Wnt ...
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Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation
... multiple signalling path- ...(Wnt/ β -Catenin) signalling pathways on zebrafish ...manipulate signalling and show that osx gene expression responds with similar kinetics to that ...
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Wnt/β catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse
... of β-catenin in epiblast progenitors leads to ectopic cardiac mesoderm at the expense of DE formation, indicating that Wnt/β-catenin signalling is essential for the specification ...
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LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
... Two of our three cell lines have NRAS mutations (SK-N-AS [12] and SH-SY5Y [48]), and, while the SK-N-BE(2)-C line does not (our unpublished data and reference 16), it has inactivating mutations of NF1, providing an ...
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Amphioxus sp5 is a member of a conserved SP complement, and is modulated by Wnt/β catenin signalling
... ABSTRACT A cluster of three Specificity Protein (Sp) genes (Sp1-4, Sp5 and Sp6-9) is thought to be ancestral in both chordates and the wider Eumetazoa. Sp5 and Sp6-9 gene groups are associated with embryonic growth ...
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Wnt Signalling During F9 Cell Differentiation
... modulate WNT signaling during development by preventing the interaction of WNT ligands with their FZD receptors and/or co-receptors ...of WNT signalling are divided into two functional ...
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Wnt/β-catenin controls follistatin signalling to regulate satellite cell myogenic potential
... non-canonical Wnt/PCP-pathway ...canonical Wnt/β-catenin pathway during adult skeletal muscle ...suggests Wnt/β-catenin signalling promotes the proliferation and ...
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RPE specification in the chick is mediated by surface ectoderm derived BMP and Wnt signalling
... and Wnt-expressing surface ectoderm is required for RPE ...that Wnt signalling from the overlying surface ectoderm is involved in restricting BMP-mediated RPE specification to the dorsal optic ...of ...
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A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling
... of Wnt/β-catenin ...activate Wnt signalling at low and inhibit at high doses ...of Wnt ligands ...modified Wnt proteins to the plasma membrane and ...of Wnt/CRD ...
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Tcf7L2 is essential for neurogenesis in the developing mouse neocortex
... Canonical Wnt signaling is mediated through activation of β-catenin and its translocation to the nucleus in which β-catenin associates with transcrip- tion factors of Tcf/Lef family and ...
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Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling
... basal Wnt signalling Finally, we sought to use Lrrk2 knockout fibroblasts to determine the effect of pathogenic LRRK2 mutations on basal canonical Wnt ...canonical Wnt signalling ...
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Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2
... to inhibit endogenous peroxidase activity and sealed with 5% normal goat serum working solution (C1771, Beijing Applygen Technology Co., Ltd., Beijing, China). After incubation for 10–15 min at 37 °C, the sections were ...
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The anti-apoptotic PON2 protein is Wnt/β-catenin-regulated and correlates with radiotherapy resistance in OSCC patients
... stabilized β-catenin enters the nucleus and interacts with transcriptional regulators, including lymphoid enhancing factor-1 (Lef-1) and T cell factors (TCFs), to activate gene transcription ...
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LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway
... Materials: Quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the expressions of CASC11 in cancerous and adjacent normal tissues of patients with cervical cancer as well as in cell lines. The ...
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Circular RNAs Regulate Cancer Onset and Progression via Wnt/β Catenin Signaling Pathway
... inhibit Wnt/β-catenin signaling pathway to impact biological ...modulate Wnt/β-catenin signaling pathway not only through the classic approach, but also via other bypass path- ...
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PubMedCentral-PMC5647938.pdf
... deregulated β -catenin sig- naling in APC-deficient radial progenitors, we expressed dominant-negative T-cell factor 4 (DNTCF; a repressor of β -catenin/TCF4-regulated transcriptional ...
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Regulation of Wnt/β-catenin signaling by posttranslational modifications
... Gsk3 β have redundant function in the Wnt/ β -catenin pathway ...canonical Wnt signaling regulates Gsk3 to inhibit β -catenin proteolysis remains largely ...in Wnt ...
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