Woodchuck Hepatitis Virus
Combination Therapy with Lamivudine and Adenovirus Causes Transient Suppression of Chronic Woodchuck Hepatitis Virus Infections
... wild-type virus present in the liver, hasten the rebound in virus titers associ- ated with emergence of lamivudine-resistant virus? In par- ticular, we examined the consequences of infection with an ...
10
Natural and experimental infection of woodchucks with woodchuck hepatitis virus, as measured by new, specific assays for woodchuck surface antigen and antibody
... Natural and Experimental Infection of Woodchucks with Woodchuck Hepatitis Virus, as Measured by New, Specific Assays for Woodchuck Surface Antigen and Antibody WONG,'* JAMES W.-K... Soli[r] ...
7
Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors
... The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle for their widespread use in human gene therapy. Here, we explored the possibility that the posttranscriptional regu- ...
7
Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication.
... The woodchuck hepatitis virus (WHV) X gene (WHx) is required for infectivity of WHV in woodchucks, and the gene encodes a broadly acting transcription ...
9
Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope.
... during hepatitis B virus (HBV) ...of woodchuck hepatitis virus (WHV) in woodchucks contributes to the understanding of these ...of woodchuck peripheral blood mononuclear cells ...
10
In Vivo Effects of Mutations in Woodchuck Hepatitis Virus Enhancer II
... Woodchuck hepatitis virus (WHV) is a mammalian hepa- dnavirus that is closely related to HBV and is strikingly onco- genic in its natural host (12, ...WHV-induced woodchuck hepatocellular ...
6
Woodchuck hepatitis virus X protein is required for viral infection in vivo.
... 4 have observed that woodchuck hepatitis virus WHV genomes bearing mutations in the X gene, in contrast to wild-type WHV genomes, were not able to initiate a viral infection in susceptib[r] ...
5
Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence.
... Recently we were able to locate within the whole cloned DNA genome of woodchuck hepatitis virus WHV the gene coding for the WHsAg protein and to compare the amino acid sequences of the s[r] ...
15
Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II.
... Woodchuck hepatitis virus (WHV) is a mammalian hepad- navirus closely related to ...chronic hepatitis, but it is even more po- tently oncogenic than HBV: virtually 100% of animals chron- ...
10
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.
... HCC has also been observed in animals chronically infected with two other hepadnaviruses: ground squirrel hepatitis virus GSHV and woodchuck hepatitis virus WHV 16, 27.. In captive groun[r] ...
7
Primary Human Hepatocytes Are Susceptible to Infection by Hepatitis Delta Virus Assembled with Envelope Proteins of Woodchuck Hepatitis Virus
... B virus (HBV) and hepatitis delta virus (HDV) share the HBV envelope ...with woodchuck hepatitis virus (WHV) are superinfected with HDV, they produce HDV with a WHV envelope, ...
8
Immunization of Woodchucks with Plasmids Expressing Woodchuck Hepatitis Virus (WHV) Core Antigen and Surface Antigen Suppresses WHV Infection
... to woodchuck hepatitis core antigen (WHcAg) and surface antigen (WHsAg) of woodchuck hepatitis virus (WHV) elicited by DNA- based ...
9
Structure and Glycosylation Patterns of Surface Proteins from Woodchuck Hepatitis Virus
... Woodchuck hepatitis virus (WHV) (39) and human hepatitis B virus (HBV) are members of the virus family Hepadnaviridae (27) which cause persistent infections of hepatocytes, ...
8
Woodchuck Gamma Interferon Upregulates Major Histocompatibility Complex Class I Transcription but Is Unable To Deplete Woodchuck Hepatitis Virus Replication Intermediates and RNAs in Persistently Infected Woodchuck Primary Hepatocytes
... of hepatitis B virus (HBV) by a noncytolytic mechanism in the transgenic mouse ...recombinant woodchuck IFN- ␥ (wIFN- ␥ ) in Escherichia coli and mammalian ...protected woodchuck cells against ...
10
Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.
... with woodchuck hepatitis virus (WHV), there appears to be a 10- to 20-fold increase in cell proliferation (16), as assessed by an increase in the number of hepatocytes reactive with an antibody to ...
8
Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens.
... 15-23 0022-538X/83/070015-09$02.00/0 Copyright © 1983, American Society for Microbiology Nonoverlapping Antigenic Sites of Woodchuck Hepatitis Virus Surface Antigen and Their Cross-React[r] ...
9
Woodchuck Hepatitis Virus Enhancer I and Enhancer II Are Both Involved in N-myc2 Activation in Woodchuck Liver Tumors
... FIG. 2. Enhancer activity of the 2260T1 viral integrant. (A) Schematic representation of the constructs used in transient transfections of HepG2 cells. N-myc2, minimal N-myc2 promoter (coordinates are relative to the ...
6
The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.
... First, we investigated whether proteins were produced from ORF5 and ORF6 by in vitro translation of appropriate viral transcripts, searched for antibodies against the putative proteins i[r] ...
9
Novel forms of woodchuck hepatitis virus DNA isolated from chronically infected woodchuck liver nuclei.
... When one calculates the sizes of generated fragment the 23.8-kb band is undi- the partial digest fragments, the map of restricgested material from partial digestion, repre- tion sites ob[r] ...
12
Expression of infectious woodchuck hepatitis virus in murine and avian fibroblasts.
... Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA.. Expression and replication of the hepatitis B virus genom[r] ...
5