Y box binding protein 1
Original Article High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer
... Abstract: Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide. Novel prognostic biomarkers are urgently warranted to help improve the treatment of CRC. Y-box-binding ...
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Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)
... phosphorylates Y-box binding protein-1 (YB-1), an oncogenic transcription/translation factor, highly expressed in TNBC (~70% of cases) and associated with poor prognosis, drug ...
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Original Article Y-box-binding protein-1 and E-cadherin are potential prognostic factors in human bladder carcinoma
... unclear. Y-Box-binding protein 1 (YB-1) is a transcrip- tion/translation regulatory factor that belongs to the cold-shock domain superfamily ...
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Serum Y Box Binding Protein 1 (YBX 1) and Interleukin 6 (IL 6) Are Associated with Metastasis in Breast Cancer Patients
... of Y-box binding protein 1 (YBX-1) and interleukin 6 (IL-6) in the sera of metastatic and non-metastatic breast cancer patients (BC), investigate their clinicopatholog- ical ...
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Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y box binding protein 1 (YB 1) and can be inhibited with Iressa in basal like breast cancer, providing a potential target for therapy
... factor, Y-box binding protein-1 (YB-1), protein is commonly expressed in ER-nega- tive breast cancers [4], and loss of this receptor is one of the hallmarks of BLBC ...
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The transcription factor X-box binding protein-1 in neurodegenerative diseases
... Unfolded Protein Response ...defective, protein aggregates overwhelm cells and affect, among other mechanisms, synaptic function, signaling transduction and cell ...exacerbated protein aggregation, ...
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Y-Box-Binding Protein 1 Interacts with Hepatitis C Virus NS3/4A and Influences the Equilibrium between Viral RNA Replication and Infectious Particle Production
... YB-1 protein was expressed and efficiently immunoprecipi- ...anti-core protein, and anti-actin ...to 1 for wild-type ...day 1 posttransfection were arbitrarily set to 1 for each ...
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Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells
... In recent years, much attention has been paid to the anti-tumor effect of emodin, with the main focus on neuroectodermal tumors, liver cancer, lung squamous cell carcinoma, merkel cell skin cancer, stomach cancer, and ...
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Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation
... viral protein involved in multiple steps in the HCV life cycle, including HCV RNA replication (14, 63), infec- tious virus production (12, 13, 15), and the recently suggested early stage of HCV RNA replication ...
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High expression of Y-box-binding protein 1 correlates with poor prognosis and early recurrence in patients with small invasive lung adenocarcinoma
... The influence of YBX1 expression and other clinical factors on the patients’ overall survival (OS) was evalu- ated. As shown in Figure 4 and Table 3, the Kaplan–Meier survival curves of all 75 patients demonstrated that ...
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Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction
... As for the dose-dependent YB-1-TOPO1 interaction perturbations in cells treated by CPT, it is an intriguing phenomenon deserves further discussion. The toxicity of CPT on cells has been reported to be ...
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X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D
... Cell lines. HONE-1/EBV is a human nasopharyngeal carcinoma cell line that stably maintains the EBV (Akata strain) genome under G418 selection in a latent form (47). HeLa is a malignant human epithelial cervical ...
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Stable expression of Y box protein 1 gene in early development of the abalone Haliotis diversicolor
... Abalone H. diversicolor is a major cultured shellfish in south coastal areas of China. Prior studies of our lab have sequenced seven non-normalized transcriptomes of H. diversicolor that covered whole early developmental ...
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Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1
... IF. Dual immunofluorescence IF for ORF45 and vIL-6 was performed on FFPE slides of MCD lymph node biopsy specimens that were deparaf- finized and rehydrated in Histo-Clear (National Diagnostics, Atlanta, GA) and an ...
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X-Box Binding Protein 1 Contributes to Induction of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle under Hypoxic Conditions
... a 1-kb splicing sequence of RTA that drives the expression of firefly luciferase (FL) (4) as well as truncated promoters named pRpluc1115-1327 (HRE2 only) and pRpluc1-550 XRE (HRE4 ...
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Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression
... up-regulating Y-box binding protein-1 (YB-1) and β-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and β-catenin that bound to the EGFR promoter ...
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<p>Elevated nuclear YBX1 expression and the clinicopathological characteristics of patients with solid tumors: a meta-analysis</p>
... Y-box binding protein 1 (YBX1) is a multifunctional protein of the cold-shock superfamily which plays different roles in both nucleus and ...by binding to the ...
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Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis
... promoting protein folding, maturation and secretion to induce ER-associated deg- radation and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) expression ...
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Characterization of the DNA-Binding Domain of the Avian Y-Box Protein, chkYB-2, and Mutational Analysis of Its Single-Strand Binding Motif in the Rous Sarcoma Virus Enhancer
... chkYB-2 binding (Table ...affinity binding by ...major protein-DNA complex formed with the double-motif oligonucleotide was comparable to the one found with the single-motif ...
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High mobility group box 1 protein, lipopolysaccharide binding protein, interleukin 6 and C reactive protein in children with community acquired infections and bacteraemia: a prospective study
... LBP is a comparatively recently identified protein synthesized mainly in liver. It binds to lipopolysacchar- ide of Gram negative bacteria, and elevated levels have been seen in infections caused by Gram positive ...
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