Y-box binding protein (YB-1)
Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)
... phosphorylates Y-box binding protein-1 (YB-1), an oncogenic transcription/translation factor, highly expressed in TNBC (~70% of cases) and associated with poor prognosis, ...
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Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y box binding protein 1 (YB 1) and can be inhibited with Iressa in basal like breast cancer, providing a potential target for therapy
... factor, Y-box binding protein-1 (YB-1), protein is commonly expressed in ER-nega- tive breast cancers [4], and loss of this receptor is one of the hallmarks of BLBC ...
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Original Article High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer
... CRC. Y-box-binding protein 1 (YB-1) has been identified as a multifunctional oncoprotein in various ...that YB-1 may promote malignant progression of CRC ...
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Original Article Y-box-binding protein-1 and E-cadherin are potential prognostic factors in human bladder carcinoma
... of Y-box binding protein 1 (YB-1) and E-cadherin with many cancers, including bladder carcinoma ...of YB-1 and E-cadherin in BC ...of YB-1 and ...
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Serum Y Box Binding Protein 1 (YBX 1) and Interleukin 6 (IL 6) Are Associated with Metastasis in Breast Cancer Patients
... protocols. Y-Box binding protein 1 (YBX-1) is an evolutionary con- served cold shock pleotropic protein that belongs to the Y-box transcription factors ...by ...
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Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation
... viral protein involved in multiple steps in the HCV life cycle, including HCV RNA replication (14, 63), infec- tious virus production (12, 13, 15), and the recently suggested early stage of HCV RNA replication ...
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Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction
... that YB-1 aggregates TOPO1 thereby enhancing DNA relaxation To explore whether the YB-1-TOPO1 interaction modu- lates the primary function of TOPO1, DNA relaxation as- says were ...GST- ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... the YB-1 protein resulted in its localization to the nucleus versus the full-length protein that remained principally in the cytoplasm ...fusion protein of GFP and truncated dbpB, it ...
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Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells
... Cell culture materials were obtained from Invitrogen (Burlington, Ontario, Canada). The reagents 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), propidium iodide (PI) and the PureLink™ HiPure Plasmid ...
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Y-Box-Binding Protein 1 Interacts with Hepatitis C Virus NS3/4A and Influences the Equilibrium between Viral RNA Replication and Infectious Particle Production
... Flag– YB-1 protein was expressed and efficiently immunoprecipi- ...of YB-1 in HCV repli- cation, HCV RNA was more abundant in cells that overexpressed Flag-YB-1 than in ...
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Physical and Functional Interaction between the Y-Box Binding Protein YB-1 and Human Polyomavirus JC Virus Large T Antigen
... fusion protein and bound to a glutathione resin while the other pro- tein was passed over the resin and analyzed for its ability to be specifically retained by the GST fusion ...between YB-1 and ...
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Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1.
... factor, YB-1. Band shift studies indicated that YB-1 and p65 modulate each other’s binding to DNA: YB-1 augments the affinity of p65 for the NF- k B site, while p65 ...
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Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression
... up-regulating Y-box binding protein-1 (YB-1) and β-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and β-catenin that bound to the ...
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High expression of Y-box-binding protein 1 correlates with poor prognosis and early recurrence in patients with small invasive lung adenocarcinoma
... mammalian protein extraction kit (KW-BIO, Beijing, Peo- ple’s Republic of China) and then quantified by BCA protein assay kit (Thermo Fisher ...(diluted 1:2,000) and GAPDH (diluted 1:5,000), ...
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GFP Fusion Proteins: A Solution or a Problem?
... The Y-box binding protein 1 (YB-1) is a pleiotropic protein involved in a widenumber of cellular processes and a substantial amount of knowledge on ...
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Functional Interaction between JC Virus Late Regulatory Agnoprotein and Cellular Y-Box Binding Transcription Factor, YB-1
... the Y-box binding protein YB-1 (6, 21, 39, 40), NF-B, Sp-1, Tst-1, NF-1, and Pur␣ (2, 6, 10, 15, 33–36, 41, ...factor YB-1 has been shown to ...
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Characterization of the DNA-Binding Domain of the Avian Y-Box Protein, chkYB-2, and Mutational Analysis of Its Single-Strand Binding Motif in the Rous Sarcoma Virus Enhancer
... DNA binding with the mutant chkYB-2 (1- 155), which has an intact CSD but no carboxyl ...DNA binding ability returned incrementally upon the progres- sive lengthening of the carboxyl tail, as ...
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<p>Elevated nuclear YBX1 expression and the clinicopathological characteristics of patients with solid tumors: a meta-analysis</p>
... Y-box binding protein 1 (YBX1) is a multifunctional protein of the cold-shock superfamily which plays different roles in both nucleus and ...by binding to the ...
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Stable expression of Y box protein 1 gene in early development of the abalone Haliotis diversicolor
... Abalone H. diversicolor is a major cultured shellfish in south coastal areas of China. Prior studies of our lab have sequenced seven non-normalized transcriptomes of H. diversicolor that covered whole early developmental ...
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Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
... of YB-1 target genes MMP-2 and collagen type I [11,37] were ...full-length YB-1 (Figure 6). Notably, co-expression of CTF and full- length YB-1 resulted in a loss of ...
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