ZAIRE-EBOLAVIRUS
Comparison of FilmArray and Quantitative Real Time Reverse Transcriptase PCR for Detection of Zaire Ebolavirus from Contrived and Clinical Specimens
... whole blood and urine (10, 11). The apparent differences likely have more to do with variations in the harshness of the protocols used to inactivate the virus in the analyte preparations than the ability of the test ...
5
Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus
... Zaire ebolavirus causes uveitis in EVD survivors [26, 27]. We have identified miRNAs produced in human RPE cells following infection with EBOV. Viruses take advantage of host miRNAs to adjust gene ...
7
Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein
... outbreak, Zaire ebolavirus was first isolated and characterized (3, ...identified: Zaire, Sudan, Taï Forest, Bundibugyo, and Reston ebolavirus ...
18
Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease
... genus Ebolavirus, on the other hand, first emerged in 1976 as the causative agent of two simultaneous VHF outbreaks in southern Sudan and northern Zaire [1, ...genus Ebolavirus, four of which are ...
19
Serological evidence of ebolavirus infection in bats, China
... of ebolavirus have been identi- fied: Ivory Coast ebolavirus, Sudan ebolavirus, Zaire ebolavirus (EBOV), Reston ebolavirus (RESTV) and Bun- dibugyo ...of ebolavirus in ...
5
High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo
... had Zaire ebolavirus species as source of ...cross-species ebolavirus antibodies ...cross-reactive ebolavirus species in the study ...unknown ebolavirus species of lower pathogenicity, ...
6
Positive Impact Program Evaluation
... The third epidemic in Zaire ebolavirus in Gabon occurred in Booue area. Virus was isolated from two of six samples from patients hospitalized at Booue (Georges, et al., 1999). A retrospective study of the ...
42
The Tyro3 Receptor Kinase Axl Enhances Macropinocytosis of Zaire Ebolavirus
... Axl, a plasma membrane-associated Tyro3/Axl/Mer (TAM) family member, is necessary for optimal Zaire ebolavirus (ZEBOV) glycoprotein (GP)-dependent entry into some permissive cells but not others. To date, ...
14
Filoviruses in Bats: Current Knowledge and Future Directions
... 4.2. Develop More Sensitive, Non-Invasive Tools for Longitudinal Monitoring of Bat Populations As part of a more unified filovirus surveillance strategy in bats, it will also be necessary to develop non-invasive sampling ...
31
Ebolavirus diagnosis made simple, comparable and faster than molecular detection methods: preparing for the future
... The Ebolavirus outbreak dominated international news in 2014 and the World Health Organization reported more than 28,000 cases worldwide and over 11,000 deaths ...of Ebolavirus outbreaks [6], based on the ...
9
The face of Ebola: changing frequency of haemorrhage in the West African compared with Eastern Central African outbreaks
... (WA) Zaire Ebolavirus disease (EVD) outbreak was characterized by an exceptionally high number of cases and deaths as compared with the Eastern-Central African (ECA) ...the Zaire Ebolavirus ...
10
Inclusion Bodies Are a Site of Ebolavirus Replication
... the ebolavirus life cycle has so far been ...of ebolavirus inclusions in viral genome replication and transcription by detecting ethynyl-uri- dine incorporation into nascent RNA followed by detection with ...
10
Replication-Deficient Ebolavirus as a Vaccine Candidate
... Ebolavirus, Ebola ⌬ VP30, which lacks the essential VP30 gene, grows only in cells stably expressing this gene product, and is genetically stable. Here, we evaluated the vaccine potential of Ebola ⌬ VP30. First, ...
6
Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry
... assumes a trimeric conformation (23), whereas sGP assembles as a parallel homodimer using two intermolecular disulfide bonds at the N and C termini of each monomer (3). ssGP is secreted as a homodimer that is held ...
12
Role of the GTPase Rab1b in Ebolavirus Particle Formation
... COPI complexes function primarily in retrograde transport FIG. 2. Dominant-negative mutants of Rab1b reduce Ebolavirus VLP production. (A) Inhibition of secretory pathways by dominant-negative mutants of Rab1a or ...
5
Novel functional hepatitis C virus glycoprotein isolates identified using an optimised viral pseudotype entry assay
... replicating molecular clone JFH-1 and chimeras derived from this virus possessing the structural genes of other viruses pro- vide a method of assessing neutralization of small panels of genetically diverse viruses ...
15
Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes
... A s evidenced by the recent crisis in West Africa, ebolavirus (EBOV) can cause widespread disease and death in human populations. Entry of EBOV into cells, which is mediated by its sole glycoprotein (GP), is a ...
6
Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses
... To construct a system for comparing these mechanisms of infection, genes encoding the MBG GP and the Zaire subtype EBO (EBO-Z) GP (provided by A. Sanchez, Centers for Dis- ease Control and Prevention), cloned into ...
5
Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins
... carrying Ebolavirus glycoprotein with glycogag and Serinc5 were unique in our ...that Ebolavirus penetrates cells by a complex, circuitous route, very different from that of any known retrovirus ...the ...
14
Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication
... Volume 7, no. 4, e00882-16, 2016, https://doi.org/10.1128/mBio.00882-16. We correct the following error in our published paper. In Materials and Methods, we described all support plasmids used in the ebolavirus ...
11