zebrafish xenograft
Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
... the zebrafish embryo model to study human tumors. Using the zebrafish xenograft model, we observed that TNBC cells make contact with the endothelium, after inoculation in the blood ...in ...
13
Zebrafish xenograft model of human lung cancer for studying the function of LINC00152 in cell proliferation and invasion
... in zebrafish xenograft model, we transplanted the SPCA1 and A549 cells with LINC00152 siRNA transfection into zebrafish ...transplanted zebrafish larvae at 1 dpi, and these selected samples ...
11
Embryonic zebrafish xenograft assay of human cancer metastasis
... the zebrafish for imaging (Wittbrodt et ...mouse xenograft models as large numbers of patient primary tumour cells are required for successful ...embryonic zebrafish xenograft assay is the ...
16
Transforming growth factor β signalling controls human breast cancer metastasis in a zebrafish xenograft model
... such, zebrafish transplanted with MDA-MB-231 or M4 cells, treated with and without SB-431542 or LY-294002 (as above) were subjected to im- munohistochemistry to determine if pSmad2 in tumour cells had been ...
13
Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
... the zebrafish xenograft model is the ability to perform high-throughput drug screening on human cancer cells and samples in a way that is not possible using any other model ...to zebrafish, for the ...
160
Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model
... into zebrafish embryos resulted in localized tumour growth and micrometastasis within 6 ...the zebrafish embryonic circulation (green) via the ventral side of the duct of ...
15
The Zebrafish Xenograft Platform – A Novel Tool for Modeling KSHV-Associated Diseases
... Positive larvae (those with a compact bolus of cells present in the yolk sac) were separated into appropriate experimental groups of 30-40 and monitored daily in 60 x 15 mm plates at 35°C. For XT cell proliferation data, ...
16
Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model
... on zebrafish embryos was initially established by a toxicity assay conducted at 35°C in 96 well-plates for 96 ...the zebrafish embryo toxicity test (OECD Test ...
17
Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos
... the zebrafish is a suitable organism for modeling UM tumor progression via engraftment, we selected F IGURE ...the zebrafish embryonic xenograft ...
11
Abstract: Though the cancer research community has used mouse xenografts for decades more than
... used xenograft models transplant human cancer cells into immunocompromised mice, the chorioallantoic membrane (CAM) of developing chicks, or into various tissue contexts within zebrafish ...serial ...
16
Zebrafish embryo, a tool to study tumor angiogenesis
... In zebrafish embryos, MO injection induce a translational block in gene function (Nasevicius and Ekker, ...2008b) zebrafish gene orthologs results in a significant inhibition of the angiogenic process ...
6
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models
... Here we demonstrate that αv integrin is required for breast cancer cell invasion and metastasis by regulating mesen- chymal markers expression and crosstalk with TGF-β sig- naling. We translate findings obtained in cell ...
16
Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish
... Figure 2. Zebrafish Foxp3 (zFoxp3). (A) Sequence comparison of putative FoxP3 genes of zebrafish, human and mouse. The stars indicate identity, dashes were introduced for optimal alignment. The zinc finger, ...
11
Zebrafish regenerate full thickness optic nerve myelin after demyelination, but this fails with increasing age
... in zebrafish, we mea- sured the G-ratio in cross sections through the lesion site in remyelinated optic nerves, compared to the unle- sioned control ...remyelinated zebrafish optic nerve, we made use of the ...
14
Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors
... Introduction: DNA repair by the nonhomologous end joining (NHEJ) pathway promotes tumor recurrence after chemotherapy and radiotherapy. Discovery of rapid and high-throughput techniques to screen for an effective NHEJ ...
9
Cannabinoids and zebrafish
... adult zebrafish (Danio rerio) of AB wild type were purchased from Selecta Aquarium Speciaalzaak (Leiden, the Netherlands) who obtain stock from Europet Bernina International BV (Gemert-Bakel, the ...
179
PubMedCentral-PMC4817687.pdf
... the zebrafish, and provides a reference for future studies investigating the crosstalk between developing zebrafish hosts and their ...adult zebrafish (such as Fusobacteria and the CK-1C4-19 class) ...
11
Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos.
... To investigate the transcriptome at the level of an in- dividual, we performed a high-resolution time course gene-expression experiment, in which on average one embryo per minute was measured from late blastula to mid ...
15
FREQUENCY OF γ-RAY INDUCED SPECIFIC LOCUS AND RECESSIVE LETHAL MUTATIONS IN MATURE GERM CELLS OF THE ZEBRAFISH, BRACHYDANIO RERIO
... Comparison of zebrafish and mouse mutagenesis: The frequency of mutations induced in zebrafish eggs or sperm appears to be higher than reported for any germ line stages in the m[r] ...
15
Nodal signaling and the zebrafish organizer
... in zebrafish have led to the discovery of mutations that affect organizer function and ...in zebrafish has thus provided a framework to understand the mecha- nisms underlying organizer ...
9