zinc finger domain
Zinc Finger Domain of Murine Leukemia Virus Nucleocapsid Protein Enhances the Rate of Viral DNA Synthesis in Vivo
... one zinc-binding motif (termed the zinc finger domain or CCHC motif) and numerous basic amino acids and is tightly associated with the genomic RNA dimer in the virion core ...the zinc ...
12
The N terminus zinc finger domain of Xenopus SIP1 is important for neural induction, but not for suppression of Xbra expression
... 4 domain-deletion mutants of XSIP1. Deletion of the N-terminus zinc finger domain suppressed neural induction and BMP inhibition, but these were not affected by deletion of the other domains ...
6
Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect
... two zinc finger domains, inhibits human immunodefi- ciency virus type 1 replication in the absence of ...each zinc finger domain. Thus, although both zinc finger domains ...
11
Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein
... the zinc finger motif did not affect nuclear export of NP at ...the zinc finger domain had a major impact on nuclear export of RNPs, the viral growth characteristics of the R101S, ...
7
ZNF300 tight self-regulation and functioning through DNA methylation and histone acetylation
... Methylation‑specific PCR (MSP) and bisulfite sequencing 293T cells were transfected with pGL3-ZNF300pro-luc plasmids with or without zinc finger domain-encod- ing region of ZNF300 on the downstream. ...
11
Abnormal Turning Behavior in Drosophila Larvae: Identification and Molecular Analysis of scribbler (sbb)
... single zinc finger (C2H2 behavior is not ...type) domain and one tyrosine kinase phosphorylation larvae carrying the rover allele of the foraging ( for) gene site that are not part of the first 929 ...
14
Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
... p1 domain, which gives rise to V1 ...p1 domain and animals lacking prdm12 function demonstrate a defective touch-evoked escape response [22, 23], suggesting that the V1 interneurons are ...p1 domain ...
19
The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.
... SETT, unpublished results). In all experiments both the full-length SUHW and zinc finger domain shifted the topoisomer distribution peak to the same direction and extent as [r] ...
13
Diastereomeric Recognition of 5',8-cyclo-2'-deoxyadenosine Lesions by Human poly(ADP-ribose) Polymerase 1 in Biomimetic Model
... the zinc finger domain of PARP1 in mediating its binding to the undamaged and damaged substrates with cdA lesions, we examined the binding of mouse PARP2 to the ...a zinc finger, the ...
17
Original Article Low nuclear zinc finger and BTB domain containing 7A expression is an independent prognostic factor for recurrence-free survival in invasive ductal carcinoma of the breast
... Zinc finger and BTB domain containing 7A (ZBTB7A; also known as factor that binds to inducer of short transcripts protein 1, Pokemon, leukemia/lymphoma-related factor, and osteo- clast-derived ...
8
Leader-Induced Phosphorylation of Nucleoporins Correlates with Nuclear Trafficking Inhibition by Cardioviruses
... Picornaviruses disrupt nucleocytoplasmic trafficking pathways during infection. Poliovirus and rhinovirus inhibit nuclear protein import/export through a series of 2A protease-dependent cleavages within nuclear pore ...
11
A barley PHD finger transcription factor that confers male sterility by affecting tapetal development
... PHD finger domain at the C-terminal region (Figure ...conserved domain is also observed in AtMS1 and OsPTC1; however, the zinc finger domain, which is seen in the Arabidopsis MS1 ...
13
Structure of Arabidopsis HISTONE DEACETYLASE15
... The zinc finger domain enhances HDA15HD dimerization and enzymatic. 796[r] ...
48
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.
... the zinc finger-like and catalytic domains of ...catalytic domain point mutants and att site deletion mutants were estimated to be ...the zinc finger-like domain synthesized much ...
10
Exploration of the determinants of protein structure and stability by protein design
... Attempts to redesign DNA binding proteins to bind alternate DNA sequences have enjoyed only modest success to date. Zinc fingers have been frequent targets for redesign. Although some investigators have argued for ...
136
Mutational analysis of the GAL4-encoded transcriptional activator protein of Saccharomyces cerevisiae.
... FIGURE 4.-(A) Sequence and proposed structure of the GAL4 zinc finger, (B) sequence of the 29 amino acids adjacent to the zinc finger, and (A and B) amino acid changes caused b[r] ...
12
Inhibition of Filovirus Replication by the Zinc Finger Antiviral Protein
... The zinc finger antiviral protein (ZAP) was recently shown to inhibit Moloney murine leukemia virus and Sindbis virus ...fourth zinc finger motif, as tested with cell lines expressing NZAP-Zeo ...
10
The GTPase domain of Galphao contributes to the functional interaction of Galphao with the promyelocytic leukemia zinc finger protein
... Fig. 2. The GTPase domain of Gαο contributes to PLZF interactions. A – A schematic diagram of the structures of Gαο GST fusion proteins (full-length and deletion mutants). N, N-terminus; L1, linker 1; L2, linker ...
11
Comparative analysis of the genetic variability within the Q-type C2H2 zinc-finger transcription factors in the economically important cabbage, canola and Chinese cabbage genomes
... the zinc fingers while the EAR motif binds to bridging proteins such as TPL or TPL-like pro- teins in Arabidopsis that subsequently interacts with HDAC proteins such as ...
11
POGZ truncating alleles cause syndromic intellectual disability
... We identified five patients with heterozygous truncat- ing mutations in POGZ. Four of the five variants were confirmed to be de novo in the affected individual; the father of patient 1 was unavailable for analysis but ...
11