[PDF] Top 20 A prediction model for progressive disease in systemic sclerosis

... of prediction of pro- gressive disease in the short term in a heterogeneous population with ...of disease duration and subtype, the study population re fl ects the whole population present in a ... See full document

... Multiple sclerosis is an idiopathic inflammatory disease of the central nervous system and the second most common cause of disability in young ...fourteen disease-modifying therapies in MSBase, an ... See full document

... Abstract: Systemic sclerosis (SSc), previously known as progressive systemic sclerosis, is a form of scleroderma and a multisystem connective tissue disease which can impact on ... See full document

... Systemic sclerosis is an acquired sporadic disease affecting all races ...year. Systemic sclerosis is an uncommon connective tissue disorder characterized by chronic progressive ... See full document

... Slowly progressive exertional dyspnea is the most common symptom of PAH. The diagnosis of PAH is a process of exclusion. In the absence of other causes, dyspnea should prompt evaluation for PAH in SSc patients, ... See full document

... In progressive systemic sclerosis the disease extends to involve the upper extremities, trunk, face, and, finally, the lower extremities, which may sometimes be ... See full document

... vascular disease in ...animal model of ...early disease and decrease with increasing disease dura- ...cardiovascular disease, in which a decreased number in the peripheral circulation ... See full document

... of disease, with approximately 25% of the patients developing sig- ni fi cant pulmonary involvement within 3 years of SSc ...lung disease (ILD) constitutes one of the most common types of direct pulmonary ... See full document

... rare disease in which visceral manifestations oc- cur, particularly peripheral vascular, digestive, cardiopulmonary and ...this disease required a high dose of corti- costeroid therapy and extra-renal ... See full document

... The progressive profile is hetero- geneous and can schematically determine three different profiles: the decliners rapid patients (approximately 25%); the median survival is less than 12 months of decliners slow ... See full document

... nective tissue disease, esophageal manometry was per- formed on seven patients with progressive systemic sclerosis, four patients with mixed connective tissue.. disease, and two patients[r] ... See full document

... Steroid and/or initiation or escalation of immunosuppressive agents is often used (especially with co- existing peripheral myositis) although a good evidence base for this does not exist. The time-course of individual ... See full document

... Systemic sclerosis (SSc) is characterised by obliterative microvasculopathy, activation of the immune system, and fibrosis of the skin and internal ...vascular disease leading to pulmonary arterial ... See full document

... Amyotrophic lateral sclerosis is a steadily progressive disease and does not usually have abrupt exacerba- tions. Swallowing gradually becomes more difficult to the point that a gastrostomy tube ... See full document

... Tobacco smoking is one of the main preventable causes of chronic disease and death. Smoking, as an environmental factor, is associated with increased risk of some autoim- mune diseases such as rheumatoid ... See full document

... The incidence of ILD in mixed connective tissue depends on the selection of patients and the method used for diagnosing the lung disorder. The prevalence of interstitial lung disease is found to be higher than ... See full document

... rapidly progressive interstitial lung disease; CADM: clinically amyopathic dermatomyositis; TIF1: transcription intermediary factors-1; TRIM: tripartite motif-containing proteins; NXP-2: nuclear matrix ... See full document

... Secondary outcome measures supported the equivalence of lithium and riluzole based upon disease progression, as measured by the ALSFRS, neurophysiological measures, clinical parameters and vital capacity. ... See full document

... The degree of perivascular and tissue accumulation of T cells, B cells, monocytes, natural killer (NK) cells, and mast cells is variable and often present early in the disease. The cytokines, growth factors, ... See full document

... tially systemic disease characterized by an inflammatory, symmetric, additive and erosive arthritis affecting about 1% of the population of developed countries ...the disease is currently not fully ... See full document