[PDF] Top 20 Activation of Focal Adhesion Kinase by Hepatitis B Virus HBx Protein: Multiple Functions in Viral Replication
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Activation of Focal Adhesion Kinase by Hepatitis B Virus HBx Protein: Multiple Functions in Viral Replication
... of HBx, including its stimulation of HBV replication (9; this ...of HBx activities by dominant-negative forms of FAK likely also involve inhibition of Pyk2 activity ...inhibit HBx activi- ties ... See full document
9
Multiple Functions of Cellular FLIP Are Essential for Replication of Hepatitis B Virus
... ABSTRACT Hepatitis B virus (HBV) infection is a leading cause of liver diseases; however, the host factors which facilitate the replication and persistence of HBV are largely ...inhibitory ... See full document
19
The Hepatitis B Virus X Protein Modulates Hepatocyte Proliferation Pathways To Stimulate Viral Replication
... HBV replication may be affected by the status of cellular proliferation pathways (29, ...HBV replication suggested that quiescent hepatocytes do not present an ideal environment for viral rep- ... See full document
12
Role of NF-κB and Myc Proteins in Apoptosis Induced by Hepatitis B Virus HBx Protein
... While HBx has been shown to display proapoptotic effects during replication of HBV and WHV in tissue culture (95), a possible proapoptotic effect of HBx during natural infection has not yet been ... See full document
11
Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication
... and HBx proteins in both WHV-infected woodchuck liver (11) and HCC cells overex- pressing HBx (reference 12 and our unpublished results) have been found in the cytoplasm, as assessed by cell fractionation ... See full document
7
Novel Roles of Focal Adhesion Kinase in Cytoplasmic Entry and Replication of Influenza A Viruses
... activates focal adhe- sion kinase (FAK) via phosphorylation of ...tyrosine kinase protein (⬃1,052 amino acids) and a major component of focal adhesion complexes ...FAK ... See full document
15
The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication
... ical functions in HBV replication remain largely ...of HBx in HBV replication with different molecular mechanisms, including ac- tivation of the calcium signaling cascade (5), proteasome mod- ... See full document
9
Hepatitis B Virus HBx Protein Activation of Cyclin A–Cyclin-Dependent Kinase 2 Complexes and G1 Transit via a Src Kinase Pathway
... with hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma in ...human virus, encodes a 17-kDa regulatory protein known as HBx (or X ... See full document
11
Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins.
... HBV HBx protein acti- vates NF- k B and characterized the DNA-binding complexes that were ...of HBx protein, its mechanism of action, and the molecular partners with which it ...the ... See full document
9
Focal Adhesion Kinase Is Involved in Rabies Virus Infection through Its Interaction with Viral Phosphoprotein P
... of viral infection on actin ...cellular functions in a kinase-independent manner. Among emerging functions of FAK, recent data implicate FAK as a regulator of mitochondrial antivi- ral ... See full document
12
Posttranscriptional regulation of hepatitis B virus replication by the precore protein.
... precursor protein inhibits HBV DNA replication. The size of the p22 protein close- ly resembles that of the processed nonsecreted HBeAg precur- sor protein (15, 31, 42, ...this protein ... See full document
9
Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner
... ayw, replication-competent 1.3-mer HBV WT, and the HBx- deficient mutant (kind gifts from ...tagged HBx WT, PCR-amplified HBx DNA (Table 1) was digested with MscI and EcoRI and inserted into a ... See full document
25
Fucoidan from Fucus vesiculosus suppresses hepatitis B virus replication by enhancing extracellular signal regulated Kinase activation
... Next, we evaluated the effect of fucoidan on HBV replica- tion in vitro. CCK8 assay showed that fucoidan was not cytotoxic at concentrations lower than 200 μg/ml on HepG2.2.15 cells (Fig. 2a). Real-time PCR revealed that ... See full document
8
Intracellular Antibody Fragment Against Hepatitis B Virus X Protein Does Not Inhibit Viral Replication
... suppresses HBx-mediated tumori- ...HBV replication even though it reduced gene transactivation in this cell line compared with cells transfected with control ...to viral proteins important in ... See full document
8
Specificity and localization of the hepatitis B virus-associated protein kinase.
... Recently, a protein kinase PK was detected in purified preparations of core particles from virus or from liver; this enzyme phosphorylates the major core protein in vitro 1.. It is not y[r] ... See full document
6
RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication.
... coli systems, a 642-bp SphI-SspI fragment carrying the T7 promoter and the 5' half of the p21.5 gene was cleaved from pARC and inserted into Downloaded from http://jvi.asm.org/ on Novemb[r] ... See full document
10
Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin
... mammalian protein expression system. The purified rTMD1 was homogeneous as judged by SDS-PAGE and western blotting (Figure 1A). Various ECM proteins, including collagen type I, type IV, fibronectin, laminin, ... See full document
18
Core particles of hepatitis B virus and ground squirrel hepatitis virus. II. Characterization of the protein kinase reaction associated with ground squirrel hepatitis virus and hepatitis B virus.
... Both activities are associated with the DNA polymerase-positive heavy core fractions on CsCl gradients which may convert to light cores during purification, phosphorylate mainly the majo[r] ... See full document
8
Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis
... tional activation of NF-κB and synergistically increases HBx-mediated NF-κB activation [13, ...NF-κB activation, we investi- gated the molecular functions of CPAP and HBx in ... See full document
14
Inhibition of Hepatitis B Virus Replication by the Interferon-Inducible MxA Protein
... MxA protein induced a marked reduction in the synthesis of envelope and capsid proteins and of HBV DNA replicative ...total viral RNAs, suggesting that MxA inhibits HBV replication at a ... See full document
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