[PDF] Top 20 Alternative splicing in prostate cancer.

... advanced prostate cancer has been better appreciated, culminating in the introduction of abiraterone and enzalutamide into routine clinical practise, which have been shown to provide additional survival ... See full document

... epithelial splicing regulatory protein 1 (ESRP1) and polypyrimidine tract binding protein 1 (PTBP1) are closely related to the expression of AS ...and prostate cancer [53, ...in splicing, ... See full document

... The Cancer Genome Atlas (TCGA) project collects RNA sequencing (RNA-Seq) data from several differ- ent types of cancer, providing a rich resource for study- ing aberrant RNA splicing in ...study ... See full document

... for alternative splicing modulators this can pose a problem, because there may be multiple down- stream pathways that are modified and these may be cell type, tissue type, and context ...the ... See full document

... the splicing factor SF35B, a non-snRNP multiprotein complex essential for spliceosome formation in which it ensures accurate excision of introns from pre-mRNA transcript by recognizing the branch site of pre-mRNA ... See full document

... of alternative splicing data based on EST predictions in human and ...had alternative splicing and in mouse the frequency of alternative splicing was estimated to 33% of the ... See full document

... An intricate regulation of hTERT expression is orchestrated by several transcription factors and DNA/histone modifying complexes at the promoter region. HSP90 (whose involvement is important for telomerase DNA binding ... See full document

... a splicing factor that stimulates CD44 alternative splicing and, therefore, the production of ...other splicing factors that stimulate or inhibit CD44 alternative splicing, in ... See full document

... cellular splicing have mainly focused on Herpes simplex virus 1 (HSV-1) and its immediate early ICP27 ...the splicing machinery and thus contributes to host protein synthesis shut-off during HSV-1 infection ... See full document

... of cancer cells [8, ...of cancer cells on a certain transcriptional regulator, which maintains an altered transcriptional pro- gram ...of cancer cells and are being tested as anti- tumor ...affects ... See full document

... breast cancer specific gene 1 (BCSG1), is localized to chromosome 10q23 and is composed of five ...multiple cancer types such as advanced stage breast and ovarian cancers ... See full document

... of alternative outcomes to cell metabolic pathway ...for cancer stem cells and splicing variants of CD133 are implicated in the complicated gene regulation in a context-dependent man- ner ... See full document

... Alternative splicing is a major mechanism for the expansion of proteomic complexity from the limited number of genes, playing critical roles in normal development and physiology ...diseases, splicing ... See full document

... the splicing pathway were not included, whereas in the present study, we identified an mRNA splicing path- way containing 6 ...the splicing of RPL9 might alter the UPF3A -mediated NMD of NR3C2 ... See full document

... Tissue specimens were collected after obtaining written informed consent permission from 40 CRC patients undergo- ing curative resection at the University Hospital S. Anna of Fer- rara over an 18-month period. ... See full document

... “noisy splicing” model makes several testable predictions, which are based on three ...of splicing errors is expected to increase with gene expression level: for a given splicing error rate, the ... See full document

... on cancer screening behaviors especially as well as enhances health-promoting behaviors in a variety of diseases [13] ...about prostate cancer, the screening rate was only ...liver cancer ... See full document

... TABLE OF CONTENTS Chapter 1: General Introduction Dissertation Organization Literature Cited Chapter 2: The ASRG database: identification and survey of Arabidopsis thaliana genes involve[r] ... See full document

... Table 2 shows clinical characteristics and biopsy outcome stratified by age category. Patients were divided into 3 age groups by cutoffs of 60 and 70 years. As expected, PSA level, prostate volume and ... See full document

... same splicing patterns in all three ...of alternative splicing were variable among the species (based on the region of the gene demonstrating differential exon usage and the direction in which exon ... See full document