[PDF] Top 20 Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia
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Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia
... (H/R)-induced cell death [25]. Thus, over-expression of the BCL2L1 gene suggests that it might be related to the occurrence of T-ALL by defective regulation of ...of T-ALL, ... See full document
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Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
... For BCL11b aberrant expression levels, deletions and mutations have been reported in T-ALL ...altered BCL11b expression and loss of function mutations in a large cohort of adult ... See full document
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Pattern of ABCC Transporter Gene Expression in Pediatric Patients with Relapsed Acute Lymphoblastic Leukemia
... resistance (MDR). This can be a result of abnormal ATP-binding cassette (ABC) transporter gene expression (4-6). The ABCC transporter subfamily of the ABC transporters is also known as multidrug resistance ... See full document
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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... smear analysis revealed an abnormal increase in the amount of lymphoblast and Immature lymphocytes (60% and ...lineage leukemia (MLL) fusion gene was ...TCR Gene rearrangement detec- tion were ... See full document
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Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... in T-ALL Transcriptional analysis of the expression level of 65 receptor and receptor-associated kinases in 32 T-ALL (test series) and normal thymic subsets (cell-sorting described in ... See full document
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Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
... ROR1 expression in lymphoid and myeloid malignancies in ...Hairy Cell leukemia compared with follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, diffuse large B cell ... See full document
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Unique amplification of BCR-ABL1 gene fusion in a case of T-cell acute lymphoblastic leukemia
... blood cell count of 109,500/mcL (differential: 31% segmented neutrophils, 25% myelocytes, 21% lymphocytes, 2% monocytes, 7% eo- sinophils, 14% blasts), hemoglobin ...cytometric analysis confirmed the ... See full document
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Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia
... lymphoblastic leukemia (T-ALL) and in three CD3- leukemic T cell lines (HSB2, CEM, and ...these patients and in the T cell lines. All T-ALL and the three ... See full document
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Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia
... The expression of the Bmi1 gene was analyzed using cells from the bone marrow at the time of recur- rence in 2 cases (of 4 relapse ...Bmi1 expression in the blast cells increased from the first onset ... See full document
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... [12–15]. T- ALL patients are more likely to have a worse steroid re- sponse than B-ALL patients [8, 10, ...and patients with ≥ 25 % blast cells in bone marrow usually have an inferior survival ... See full document
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WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
... in acute leukemia still remains unclear, and the role of WT1 in the process of leukemogenesis is not well ...WT1 expression patterns and its clinical implications in childhood ALL, we ... See full document
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The molecular basis of T cell acute lymphoblastic leukemia
... forced expression of Lmo2 in mouse T cell progenitor cells confers self-renewal capacity to this normally non–self-renewing population ...stem cell properties and the oncogenic effects of LMO2 ... See full document
10
Protein kinase inhibitors for acute leukemia
... Acute leukemia is subdivided into acute myelocytic leukemia (AML) and acute lymphoblastic leukemia (ALL) [1, ...all acute leukemias in adults, and the cure rates ... See full document
7
Profile of blinatumomab and its potential in the treatment of relapsed/refractory acute lymphoblastic leukemia
... cytotoxic T-cells to CD19+ target B-cells inducing serial perforin-mediated ...(R/R) acute lympho- blastic leukemia (ALL) and in ALL with minimal residual ...to its approval by the US Food and ... See full document
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<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... Childhood Lymphoblastic Leukemia (GBTLI-ALL 99/09) or to ALL Berlin- Frankfurt- Münster (BFM-ALL 95 and 2002) ...17,18 Patients were assigned into the group of a high risk of relapse, according to ... See full document
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Immunotherapy in hematologic malignancies: past, present, and future
... CAR T cells would not be complete without highlighting the CRS, an inflammatory process related to exponential T cell proliferation associ- ated with massive cytokine ...CAR T cells have ... See full document
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Immunoglobulin mu chain gene rearrangement in a patient with T cell acute lymphoblastic leukemia
... with T cell acute lymphoblastic leukemia (ALL) is ...expressed T cell-associated antigens (Leu 1+, OKT3+, OKT9+, and ...mu-chain gene rearrangement with germ-line ... See full document
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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines
... by patients with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor ...of T-ALL relapse patient ...p53 gene. ... See full document
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Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor
... A 9-year-old boy was diagnosed with AML-M5 by French American British (FAB) classification in December 2005. The bone marrow aspirate showed 100% blasts and cere- brospinal fluid was positive for leukemic blasts. ... See full document
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Childhood leukemia: central nervous system abnormalities during and after treatment
... Bacterial or fungal infections associated with neutropenia are common in patients with newly diagnosed or recurrent acute leukemia (32, 33). Three of our five patients with CNS infections had ... See full document
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