[PDF] Top 20 Analysis of gene copy number changes in tumor phylogenetics
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Analysis of gene copy number changes in tumor phylogenetics
... of tumor cells from the FISH copy number data and show that such a progression of FISH cell count patterns over a tree effectively models the evolution of tumor ...single gene ... See full document
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Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
... acquiring tumor tissue can partly be addressed by elaborate procedures such as rapid autopsy programs to obtain high-quality metastatic tissue for analysis ...circulating tumor cells (CTCs) in ... See full document
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Molecular classification of tissue from a transformed non-Hogkin’s lymphoma case with unexpected long-time remission
... global gene expression in a patient with unexpected long‑term remission following ...resistance gene signatures (REGS) for R‑CHOP as described at ...component analysis, mutation screening and ... See full document
10
Genome-Wide Analysis of DNA Copy Number Changes in Liver Steatosis
... lower copy number at chromosome region 3q29 than reference ...MUC20 gene mapping to this region, and represented for more than three consecutive probes in the array, encodes for a protein that ... See full document
13
High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors
... measuring copy number gains or ...measure copy number changes in ovarian serous carcinoma ...of copy number changes across the genome, focusing on rare ... See full document
15
<p>Prognostic Value of Plasma HER2 Gene Copy Number in HER2-Positive Metastatic Breast Cancer Treated with First-Line Trastuzumab</p>
... metastatic tumor tissues and plasma was lacking, because HER2 gene ampli fi cation by FISH was not available for all metastatic patients in this retrospective ...ROC analysis has been performed to ... See full document
11
Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics
... on gene copy number variation (CNV) in 10 breast cancer metastatic brain tumors, assayed by array comparative genomic hybridization ...Cancer gene aberrations were identified in all specimens ... See full document
11
Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples
... genomic analysis of DNA methyla- tion showed large genomic regions that are highly methylated in neurons compared to fibroblasts that span large regions of 15q11-q13 ...MS-HRM analysis of the PWS-IC ... See full document
15
TRAF6 is an amplified oncogene bridging the RAS and NF κB pathways in human lung cancer
... and copy number alterations (as a result of deletion or amplification of large portions of a chromosome) are major drivers of human lung ...Detailed analysis of lung cancer–associated chro- mosomal ... See full document
12
MET amplification as a potential therapeutic target in gastric cancer
... the number of centromeric signals directly reflects the copy number of the chromosome, FISH analysis yields the copy number gain for the target gene from the ratio of the ... See full document
9
Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer.
... Based on the outcome of the COG trial, we hypothesized that there was a subgroup of patients whose tumors were driven by EGFR signaling and who, accordingly, benefitted from treatment with gefitinib. This is analogous to ... See full document
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Genomic Subtypes of Non-Invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency
... extensive analysis of the genome of MIBC (Gui et ...candidate gene analysis include mutations in the TERT promoter, activating point mutations in FGFR3 and PIK3CA, and inactivating mutations in STAG2 ... See full document
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Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis
... and gene copy numbers for the 15,942 genes con- sidered in the CCLE cancer cell line data ...obtain gene-specific copy number log-ratios for each tumor patient, we mapped the ... See full document
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Genomic Stability of Palmer amaranth Plants Derived by Macro Vegetative Propagation
... some changes occurred in the genetic profiles may be important in characterizing the stability and primal cause(s) involved in the phenomenon of elevated EPSPS gene copy num- ...qPCR analysis ... See full document
10
Low copy number of the FCGR3B gene and rheumatoid arthritis: a case control study and meta analysis
... An update of the meta-analysis for the association of low FCGR3B CN (< 2) with RA, originally reported by McKinney and colleagues [17], was also performed, which included two subsequently published studies ... See full document
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iSOM-GSN: An Integrative Approach for Transforming Multi-omic Data into Gene Similarity Networks via Self-organizing Maps
... CNNs are a type of neural networks that are proven to be very effective in image classification and sequence prediction problems. In many applications, position and frequency of features are not relevant for learning and ... See full document
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Gerland, Thomas (2017): The Drosophila speciation factor HMR localizes to genomic insulator sites. Dissertation, LMU München: Medizinische Fakultät
... While only one insulator protein, CCCTC-binding factor (CTCF), is known in vertebrates, arthropods have experienced a successive gain of insulator proteins during evolution (Heger et al., 2013; Pauli et al., 2016; ... See full document
135
A next-generation sequencing method for overcoming the multiple gene copy problem in polyploid phylogenetics, applied to Poa grasses
... nuclear gene, known as homeologues, it is usually impos- sible to amplify a homogeneous, single amplicon using ...one copy is amplified with a particular PCR primer pair, direct sequencing will give double ... See full document
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... Three commonly used cell lines (293T cells, GC-1 cells and GC-2 cells) were employed for the function analysis in vitro [51–54]. All cell lines were cultured in DMEM (Gibco, USA), with 10% fetal bovine serum (FBS) ... See full document
9
Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number
... 51p1 gene locus is highly polymorphic, consisting of 13 alleles that can be classified as being either 51p1-related or hv1263-related, based on distinctive se- quence motifs in the second complementarity ... See full document
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