[PDF] Top 20 Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals
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Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals
... adsorption analysis were based on clade B strains BaL and ...protein from each of the strains could sufficiently adsorb significant neutralization activity (Table 1) against heterolo- gous ... See full document
15
Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies
... ing human monoclonal antibodies (MAbs) that have been iso- lated from HIV ⫹ clade B-infected human donors (35, ...some from different clades, indicating that certain elements of Env ... See full document
21
Genetic and Functional Analysis of R5X4 Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Derived from Two Individuals Homozygous for the CCR5Δ32 Allele
... Approximately 1% of Caucasians are homozygous for a non- functional CCR5 allele containing a 32-bp deletion (CCR5 ⌬ 32) ...of human immunodeficiency virus type 1 (HIV-1) ... See full document
8
Cross-Clade Neutralizing Activity of Human Anti-V3 Monoclonal Antibodies Derived from the Cells of Individuals Infected with Non-B Clades of Human Immunodeficiency Virus Type 1
... the neutralization of luciferase-encoding virions pseudotyped with the desired HIV-1 Env proteins, as previously described ...The virus-MAb mixtures were added to HOS-CD4 ⫹ CCR5 ⫹ cells (NIH ARRRP ... See full document
8
Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals.
... the virus, indicating that their presence could be beneficial in preventing vertical transmission (48, ...HIV-2-infected individuals, higher titers of NA (5, 54) and a lower rate of genome ... See full document
8
Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity
... Functional analysis of these molecularly cloned envelope genes was performed by incorporation of the molecularly cloned envelope protein into pseudotyped HIV ...provirus derived from the molec- ... See full document
5
Neutralizing Antibodies in Sera from Macaques Infected with Chimeric Simian-Human Immunodeficiency Virus Containing the Envelope Glycoproteins of either a Laboratory-Adapted Variant or a Primary Isolate of Human Immunodeficiency Virus Type 1
... Sera from SHIV-infected macaques were assessed for their ability to neutralize multiple SHIV variants and heterologous TCLA strains of HIV-1 (MN and SF-2) in either MT-2 or CEMx174 cells as ... See full document
5
Factors Determining the Breadth and Potency of Neutralization by V3-Specific Human Monoclonal Antibodies Derived from Subjects Infected with Clade A or Clade B Strains of Human Immunodeficiency Virus Type 1
... primary virus isolates remains an elusive goal of HIV-1 vaccine ...“principal neutralization domain” of HIV-1 (16), subsequent data re- sulted in more pessimistic attitudes about the ... See full document
9
Multivariate analysis of human immunodeficiency virus type 1 neutralization data.
... map analysis. The neutralization data in Table 1 were subjected to spectral map ...extracted from neutralization data in Table 1 by spectral map analysis account for the ... See full document
9
An Envelope Modification That Renders a Primary, Neutralization-Resistant Clade B Human Immunodeficiency Virus Type 1 Isolate Highly Susceptible to Neutralization by Sera from Other Clades
... of polyclonal anti-HIV ...the virus susceptibility to neutralization by polyclonal sera collected from patients in- fected with clade B viruses (Table ...to neutralization ... See full document
6
Comparison of the Antibody Repertoire Generated in Healthy Volunteers following Immunization with a Monomeric Recombinant gp120 Construct Derived from a CCR5/CXCR4-Using Human Immunodeficiency Virus Type 1 Isolate with Sera from Naturally Infected Individuals
... of sera from infected individuals, serological rec- ognition of other linear peptides was poor ...of sera from these immunized individuals which bound peptides ... See full document
6
Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera.
... a polyclonal HIV anti- serum ...with 1% formalin prior to dual-parameter flow cytometric analysis (PE, 532 nm; FITC, 488 ...CD4 1 lymphocyte population was compared with PE staining of the CD4 ... See full document
10
Antibody Specificities Associated with Neutralization Breadth in Plasma from Human Immunodeficiency Virus Type 1 Subtype C-Infected Blood Donors
... the specificities of the anti-human immunodeficiency virus type 1 (HIV-1) envelope antibodies able to mediate broad heterologous neutralization will assist in ... See full document
13
Evidence that Antibody-Mediated Neutralization of Human Immunodeficiency Virus Type 1 by Sera from Infected Individuals Is Independent of Coreceptor Usage
... of virus neutralization by sera from infected individuals, coreceptor usage probably does not de- termine the ability of HIV-1 to be neutralized by ...used human ... See full document
8
Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected Donors
... by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited ...cross- neutralization of HIV-1, we have characterized the neutralizing ... See full document
15
Neutralizing Antibodies from the Sera of Human Immunodeficiency Virus Type 1-Infected Individuals Bind to Monomeric gp120 and Oligomeric gp140
... reagents. Sera from patients US20 and US22, selected based on their broad and strong neutralization of primary HIV-1 isolates, were ob- tained with informed consent from clade B ... See full document
12
Neutralization Profiles of Sera from Human Immunodeficiency Virus (HIV)-Infected Individuals: Relationship to HIV Viral Load and CD4 Cell Count
... primary human immunodeficiency virus (HIV) in- fection, there is little heterogeneity among HIV strains isolated from an individual ...the virus population (3, 12, ...or ... See full document
5
Both Memory and CD45RA+/CD62L+ Naive CD4+ T Cells Are Infected in Human Immunodeficiency Virus Type 1-Infected Individuals
... cells from patients carrying replication-competent HIV-1, micrococul- ture assays were carried out as previously described ...a 1/4,000 dilu- tion) and irradiated autologous PBMCs were added to the ... See full document
6
Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1.
... taken from C499 at the time of acute ...taken from an age-matched, uninfected ...hybridization analysis of the lymph node section in panel A. Digoxigenin-labeled HIV-1 riboprobes were ... See full document
6
Evolution of Lamivudine Resistance in Human Immunodeficiency Virus Type 1-Infected Individuals: the Relative Roles of Drift and Selection
... wild type in the presence of drug, leading to a rapid replacement of the wild type in patients on mono- ...widely from 0.12:1 to 0.33:1 among the seven ...tween individuals gave ... See full document
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