[PDF] Top 20 Are animal models predictive for humans?
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Are animal models predictive for humans?
... between animal carcinogens and human carcinogens strong enough so the animal model can be said to be predictive, then we see much evidence to sup- port the null hypothesis but very little if any to ... See full document
20
Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models
... Since the emergence of this H7N9 virus, experimental infec- tions in ferrets (Mustela putorius furo), cynomolgus macaques (Macaca fascicularis), laboratory mice (Mus musculus domesticus), domestic pigs (Sus scrofa ... See full document
5
The clinical relevance of animal models in Sjögren’s syndrome: the interferon signature from mouse to man
... mouse models for clin- ical relevance in humans, a proper understanding of both the similarities and differences in immune function between mouse and man remains crucial for adequate interpretation of mouse ... See full document
12
Amelioration of Murine Dry Eye Disease by Topical Antagonist to Chemokine Receptor 2
... Studies in various animal models and humans have made it clear that desiccating stress is often associated with Tcell infiltration of the conjunctiva.15,16 The T cells migrate into the p[r] ... See full document
7
In vivo antidepressant and anxiolytic activities of ethanol extract of Trema orientalis leaves in mice
... using animal behavioral ...valid animal model able to sufficiently and accurately identified diverse depressant treatments, without making errors of omission ... See full document
6
Facing the Challenge of Data Transfer from Animal Models to Humans: the Case of Persistent Organohalogens
... in animal models and human ...from animal studies due to the following: 1) the significant delay between the commercialisation of a substance and studies with animal models; 2) ... See full document
18
Animal models and conserved processes
... between humans and animals when BSA is taken into account ...six animal species and concluded that the maximum tolerated dose (MTD) for humans was 1/12 of the dose in mice that resulted in the death ... See full document
33
A review on the development of individual-based model in ecology
... in animal-aspect ...the models about animal populations, because in order to assess the impact of humans having on the mortality of young fish, abundance in fish population number and ... See full document
18
A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review
... to humans (Table 1), probably because of genetic similarity and similar demands during ...in humans and rhesus mon- keys which can be associated with a different load on the femur in these species ... See full document
13
The enigma of sepsis
... infusion animal models did not accurately reflect clinical developments in human ...in humans) were found to be very low, and extreme elevations of TNF-α levels were not observed in rodent LPS ... See full document
9
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL 13 transdifferentiation signals
... First, altered EGFR expression has been found in humans with asthma known to exhibit goblet cell metaplasia and in animal models of asthma, but expression has been variably found on gobl[r] ... See full document
14
Rheostat regulation of integrin mediated leukocyte adhesion
... Multiple lines of evidence from animal models and diseased humans have Nonstandard abbreviations used: ADMIDAS, adjacent to metal ion–dependent adhesion site; CAM, cell adhesion molecule[r] ... See full document
6
“Reverse torque of 30 Ncm applied to dental implants as test for osseointegration”—a human observational study
... in humans [5, 9], last phase of study, and counting on previous results from in vitro and in vivo researches with animal models on long bones (femur, tibia, mandibles) in dogs, pigs, baboons, ... See full document
6
A General Model of Zoonosis Where the Diseases Can Only Be Transmitted from Animals to Humans
... different models for different infectious diseases [13] [14] ...Many models consider the vaccination [12] [16], but there are only a few people get vaccinated in poor area, even there is not an effective ... See full document
11
The post 2009 influenza pandemic era: time to revisit antibody immunodominance
... vaccinated humans and experimentally infected mice, guinea pigs, and ferrets, which are the three most commonly stud- ied animal models for influenza ... See full document
5
The institutional review board is an impediment to human research: the result is more animal-based research
... of animal models with a strong capacity to predict human efficacy” ...preclinical animal modes to predict human ...that animal models have misled scientists into taking wrong research ... See full document
10
On the predictive utility of animal models of osteoarthritis
... Age is one of the strongest risk factors for OA. Ageing causes changes in chondrocytes and articular cartilage, as well as in other joint tissues (meniscus, ligaments, bone, and synovium) and these age-related changes ... See full document
14
The Nuremberg Code subverts human health and safety by requiring animal modeling
... among humans. Indeed, humans vary so much in our response to chemi- cals that the majority of drugs are only an option for a minority of ...as models for humans. For which humans are we ... See full document
17
Predictive formulas expressing relationship among dose rate, duration of exposure and mortality probability in total body irradiation in humans
... mathematical models in the literature that express the quantitative relationship among dose rate of radiation, duration of exposure and mortality probability and /or to determine LD 50 for humans in ... See full document
9
Marburg virus pathogenesis – differences and similarities in humans and animal models
... in humans, but requires an adapted virus, and has a limited array of commer- cially available reagents and ...The animal models for MVD reviewed in this paper are effective at recapitulating human ... See full document
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