[PDF] Top 20 Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis

... of COMT Val158Met polymorphism on BC risk were ...with COMT 1222 G>A polymorphism ...the meta-analysis ...between COMT Val108/158Met polymorphism ... See full document

... MCF-7 breast cancer cells, inducing extracel- lular regulated kinase1/2 (ERK1/2) activation and transcriptional activity, which finally results in upregulation of the expression of VDR gene ...the ... See full document

... with cancer risk [32]. The NQO1 Pro187Ser polymorphism is a C-to-T transition in the NQO1 gene which leads to a proline to serine amino acid substitution at codon 187 in the protein ...Pro187Ser ... See full document

... We used the methods of the Newcastle-Ottawa Scale (NOS) to assess the quality of the studies included in our meta-analysis. As a result, three studies [7,18,20] were rewarded eight stars, while two studies ... See full document

... pancreatic cancer, cervical cancer, and esopha- geal cancer ...and breast cancer susceptibility has existed for a long ...the association between MTHFR gene 1298A>C ... See full document

... stratified meta- regression analyses to explore major causes of heterogeneity among the ...the association between genetic mutants and cancer risk in allelic contrast (T vs C), homozygote ... See full document

... this meta-analysis is based on single-factor calculation without adjustment by other important co-variables, such as meno- pausal state, age of menarche, tobacco smoking habit, life- style factors, and ... See full document

... Different cancer types might contribute to the overall result of our ...our meta-analysis, bladder cancer, colorectal cancer, breast cancer, and gastric cancer were ... See full document

... 28. Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, Scollen S, Baynes C, Ponder BA, Chanock S, Lissowska J, Brinton L, Peplonska B, Southey MC, Hopper JL, McCredie MR, Giles GG, Fletcher O, ... See full document

... bladder cancer patients and the health ...bladder cancer, and the homozygous genotype for the common allele of each SNP was used as the reference in the logistic regression ...the association between ... See full document

... to cancer (n = 34), and articles were not related to COMT (n = ...this meta- ...43,085 cancer cases and 57,882 control subjects were included in our meta- ...bladder cancer, two ... See full document

... a meta-analysis, suggesting that the allele met has a low association with risk of cancer (except breast and bladder cancers), contrary to the expected based on the biochemical ... See full document

... the association of the -160C/ A polymorphism with the risk and progression of various human cancers ...the polymorphism ’ s genetic effects vary in different cancer ...increased ... See full document

... a meta-analysis of pub- lished studies to evaluate the association between p73 G4A and risk of gastric cancer, because no such analysis has been reported to ...this ... See full document

... suicide show familial behavior. Family studies have found that those patients more likely to display suicidal behavior have parents with a history of suicidal beha- vioral with a heritability of about 40-50% [7-11]. A ... See full document

... separate from the alexithymic construct as it reflects a style of avoiding introspective thought rather than specifically measur- ing alexithymia. Another possible reason for the lack of associa- tion between COMT ... See full document

... colorectal cancer risk, high- protein diet could lead to DNA damage of colonocytes, decrease colonic mucosal thickness, and reduce the height of the colonocyte brushborder membrane [4 – ...the risk ... See full document

... this meta-analysis, unpublished data and ongo- ing studies were not sought, which may have biased our ...cise analysis would have been conducted if more detailed individual data were ...this ... See full document

... This meta-analysis had stronger statistical power compared with previous single studies, but some limitations might affect our conclu- ...relative risk of TC were not evaluated owing to the lack of ... See full document

... The findings of this study indicate that VDR gene polymorphism may have a significant role in increasing the risk of one of the most common adult hematologic malignancies known as AML. Since medical science ... See full document