[PDF] Top 20 Axonal Transport: A Constrained System
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Axonal Transport: A Constrained System
... demonstrated how the increased viscosity due to the wall effect and macromolecular crowding can impede axonal transport. They started by considering the simple case of a single motor hauling a cargo through ... See full document
5
Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features
... DRG from the different experimental groups were lysed in 250 μl methanol/acetonitrile 1:1 containing [U-13C6]-Glucose-1 ng/μl (internal standard, Sigma Aldrich, 389374) by tissue lyser and spun at 20,000 g for 5 min at 4 ... See full document
14
Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
... various axonal connections through the CNS is supported by key observations: first, the seemingly dynamic association of structural viral material along axons both ex vivo and in vitro ... See full document
21
Receptor-Dependent and -Independent Axonal Retrograde Transport of Poliovirus in Motor Neurons
... PV transport in hPVR-Tg mice ranges from ...and transport of PV in non-Tg mice, and in hPVR-Tg mice in the presence of MAb p286, are comparable to each other and much lower ...PV transport do coexist ... See full document
10
Retrograde Axonal Transport: a Major Transmission Route of Enterovirus 71 in Mice
... A steady viremia was constantly observed before and at the same times as detection of EV71 in the CNS. Therefore, the question of whether or not viremia was responsible for the transport of the viruses to the CNS ... See full document
8
Two Modes of Herpesvirus Trafficking in Neurons: Membrane Acquisition Directs Motion
... nervous system is dependent upon the long-distance intra- cellular transport of viral particles in ...of axonal transport has, in part, been obscured by contradictory findings regarding ... See full document
6
Dual Role of Herpes Simplex Virus 1 pUS9 in Virus Anterograde Axonal Transport and Final Assembly in Growth Cones in Distal Axons
... anterograde transport and assembly of HSV-1 in the distal axon of human and rat dorsal root ganglion (DRG) neurons using US9 deletion (US9 ⴚ ), repair (US9R), and wild-type (strain F, 17, and KOS) ...anterograde ... See full document
11
The disruption of mitochondrial axonal transport is an early event in neuroinflammation
... II respiration together with complex I respiration in the OXPHOS CI + CII state; oligomycin (2 μg/ml; Sigma) to detect endogenous uncoupled respiration from ATP syn- thesis through complexes I and II substrates by ... See full document
15
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein
... APP-YFP movement was monitored in vivo in adult Drosophila sensory wing neurons essentially as de- scribed for other fluorescent protein-tagged cargoes [53, 54, 58]. Images were captured using a Nikon spinning disk ... See full document
13
Selective spread of herpes simplex virus in the central nervous system after ocular inoculation.
... In a similar fashion, axonal transport was probably responsible for the spread of the virus to the neurons of the midline raphe nuclei, nucleus locus coeruleus, and VII nerve nuclei by 5[r] ... See full document
6
Network Slicing And Performance Analysis Of 5g Networks Based On Priority
... the system execution perspective, cutting suggests that each 5G cut needs to have its own arrangement of distributed assets, this angle presents an oddity in the administration of system assets in versatile ... See full document
5
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
... Axonal transport of mitochondria in rat cortical neurons ...mitochondrial axonal transport in cortical neurons was performed with an Axiovert S100 microscope (Carl Zeiss) equipped with a ... See full document
12
Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.
... Transblot system (BioRad) and, following blocking with Tris – HCl buffered saline (TBS) containing 5% milk powder and ...chemiluminescence system (GE ... See full document
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Ladwig, Anne (2017): Morphologische Analyse der distalen Auswirkungen des axonalen Transportdefizits in einem Tiermodell der Multiplen Sklerose. Dissertation, LMU München: Medizinische Fakultät
... its transport system, anterograde transport may be inhibited and wider ranging transport modifications can be suggested ...anterograde transport deficits are apparent PINK1, Parkin, ... See full document
164
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains
... Cells were harvested for SDS-PAGE and immunoblot- ting by scraping into SDS-PAGE sample buffer contain- ing 2% ( w/v ) SDS, 100 mM dithiothreitol, 10% ( w/v ) glycerol, 0.1% ( w/v ) bromophenol blue and protease in- ... See full document
16
Decreased axonal transport of structural proteins in streptozotocin diabetic rats
... various axonal transport rates in sciatic nerve of streptozotocin diabetic rats 3 h and 10,25, and 50 d after the injection of tritiated proline into the fifth lumbar dorsal root ...slow transport ... See full document
7
Axonal Transport and Sorting of Herpes Simplex Virus Components in a Mature Mouse Visual System
... and transport of two major proteins of herpes simplex virus (HSV) has been determined for mature mouse retinal ganglion cell axons in ...viral transport in neurons and suggest that there is a 4- to 5-day ... See full document
10
Axonal degeneration in paraplegin deficient mice is associated with abnormal mitochondria and impairment of axonal transport
... anterograde axonal transport. Axonal transport is an energy- dependent process that is especially crucial to the long axons affected in HSP, which transport molecules and organelles ... See full document
13
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation
... Figure 3 Models of HTT-cargo complexes and their regulation during transport. Notes: (A) HTT may attach to BDNF or Rab protein containing vesicles and associate with kinesin-1 and dynein via interactions with HAP1 ... See full document
19
Anterograde Glycoprotein-Dependent Transport of Newly Generated Rabies Virus in Dorsal Root Ganglion Neurons
... restricted transport of cytoplasmically expressed RNP proteins, we included recombinant NDV EGFP-P-expressing Newcastle disease ...from transport into axons of infected DRG neurons ...particle ... See full document
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