[PDF] Top 20 B cell selection and the development of autoantibodies
Has 10000 "B cell selection and the development of autoantibodies" found on our website. Below are the top 20 most common "B cell selection and the development of autoantibodies".
B cell selection and the development of autoantibodies
... nity B cells and generation of class- switched antibodies ...the B cells by promoting the expression of ...murine B cells missing type I interferon receptor respond weakly to TLR7 ligands ...naive ... See full document
13
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions
... the development of cardiovascular pathologies that can lead to serious complica- tions, including stroke or myocardial infarction (2, ...many cell types, but the precise cellular events that allow its ... See full document
17
Developments in the scientific and clinical understanding of inflammatory myopathies
... Although the exact pathogenesis of idiopathic inflammatory myopathies remains obscure, some scientific endeavors during the past decade have brought us closer to understanding the pathophysiology of these diseases. There ... See full document
10
Systemic translocation of Staphylococcus drives autoantibody production in HIV disease
... of B cells has revealed that high ANA HIV+ subjects had upregulation of IL1B and IL23 genes, which favor immune activation and are essential for disease development in several models of autoimmune disease ... See full document
16
B cell targeted therapeutics in clinical development
... However, B cells can also be pathogenic and the origin of disease. Deregulated B-cell function has been implicated in several autoimmune diseases, including systemic lupus erythematosus, rheumatoid ... See full document
21
Therapeutic implications of autoantibodies in rheumatoid arthritis
... DIAGNOSTIC ASSOCIATIONS OF AUTOANTIBODIES FOR RA RF and ACPA have been associated with the diagnosis of RA. RF has been associated with a diagnosis of RA when used in patients with early undifferentiated arthritis ... See full document
8
Checkpoints that control B cell development
... developing B cell repertoires at check- points 2 and ...the development of SLE, as in the complement components C1q, C4, and CR2, serum IgM, or serum amyloid protein, have been used to formulate two ... See full document
9
B cell antigen receptor isotypes : implications for immune memory
... “ligand” selection, to explain observations such as V h gene useage and clonal enrichment in certain B cell subsets (Gu, 1991; Martin, 1999; Pillai, ...that B cells are selected and maintained ... See full document
248
MicroRNAs in B cell development and malignancy
... miRNAs can be grouped in to at least three categories depending on their genomic location: exonic miRNAs in non-coding genes, intronic miRNAs in non-coding genes and intronic miRNAs in protein-coding genes [9]. miRNAs ... See full document
10
Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib
... of B-NHL, copanlisib might offer greater effi- cacy than idelalisib in situations where alternative isoforms are upregulated in response to selective PI3K δ inhibition as a resistance ...The selection of ... See full document
14
Recent advances in the biology and treatment of B-cell acute lymphoblastic leukemia
... The improved outcomes with TKIs set the stage for the consideration of chemotherapy de-escalation for the treat- ment of Ph + ALL to lessen the morbidity and mortality associated with induction chemotherapy. In ... See full document
15
<p>How the discovery of rituximab impacted the treatment of B-cell non-Hodgkin’s lymphomas</p>
... Abstract: Non-Hodgkin’s lymphoma (NHL) is the sixth-most common cancer in the UK, accounting for around 13,700 new cases every year. Until the late 1990s, treatment relied on intensive chemotherapy, such as CHOP ... See full document
14
Diffuse large B-cell lymphoma of the breast: prognostic factors and treatment outcomes
... A total of 113 patients were included in the analysis: 42 cases (37%) from our hospital and 71 cases (63%) from 12 pub- lications. The baseline characteristics of the patients are shown in Table 2. The median age at ... See full document
12
<p>miR-19 promotes the proliferation of clear cell renal cell carcinoma by targeting the FRK–PTEN axis</p>
... cancer cell proliferation via the FrK–PTen axis. (A, B) The effects of mir-19a/b-3p on the proliferation of achn cells were analyzed by ccK-8 ... See full document
15
Generation and analysis of clonal IgM and IgG producing human B cell lines expressing an anti DNA associated idiotype
... immunoglobulin V gene utilization in an anti-DNA-associated idiotypic system. The 31 anti- DNA-associated idiotype is encoded preferentially by the VK1 gene family, and, in all probability, reflects a germ line ... See full document
8
Intraclonal Cell Expansion and Selection Driven by B Cell Receptor in Chronic Lymphocytic Leukemia
... The following antibodies were used: FITC-conjugated anti-IgD (DAKO, Glostrup, Denmark), PE-Cy5 conjugated anti-IgM (BD, Franklin Lakes, New Jer- sey, USA), APC-conjugated anti-IgG (BD), PE- conjugated anti-CD3 (BD), ... See full document
6
Update on the use of rituximab for intractable rheumatoid arthritis
... depleted B cells, was approved by the FDA for the treatment of moderate to severe rheumatoid arthritis (RA) with an inadequate response to anti-TNF thera- ...including B cell subsets in peripheral ... See full document
12
Advancement and applications of peptide phage display technology in biomedical science
... Membrane receptors are pivotal for cell-cell biochemical and electrical signaling in essential physiological func- tions. Therefore, the pharmaceutical industries tend to focus on developing drugs targeting ... See full document
14
Datafication and the Development of Global Digital Civilizations
... the development of new kinds of study programmes for archivists and museums due to technol- ogy would mean that eventually other fields would be impacted too, leading to new methods and content in ... See full document
16
Increased frequency of circulating IL 21 producing Th cells in patients with granulomatosis with polyangiitis (GPA)
... and APC-conjugated anti-CD3 for 15 minutes at room temperature. Cells were fixed with 100 μL Reagent A (Cal- tag/Invitrogen., Breda, The Netherlands) for 10 minutes. After washing, the pellet was resuspended in 100 μL ... See full document
12
Related subjects