[PDF] Top 20 B Cells Regulate Murine Gammaherpesvirus 68 Latency
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B Cells Regulate Murine Gammaherpesvirus 68 Latency
... of cells that reactivate gHV68 and the frequency of cells that carry gHV68 genome, we were able to determine the parameters that reg- ulate gHV68 ...genome-positive cells at this site are latently ... See full document
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Macrophages Are the Major Reservoir of Latent Murine Gammaherpesvirus 68 in Peritoneal Cells
... of B cells harboring the viral genome in the peritoneum of latently infected C57BL/6 ...for B cells), and relevant cell populations were isolated by FACS ...(A) Cells were pregated into ... See full document
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The Murine Gammaherpesvirus 68 M2 Gene Is Required for Efficient Reactivation from Latently Infected B Cells
... HV68 latency in specific B-cell subsets in the spleen at late times ...various B-cell populations at early times postinfection, while long-term latency is main- tained in memory B ... See full document
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Alpha/Beta Interferons Regulate Murine Gammaherpesvirus Latent Gene Expression and Reactivation from Latency
... viral latency, suggesting that IFN- ␣ /  exerts antiviral effects on latent cells, thereby leading to selective pressure to maintain vIRF expres- sion (9, 31, 65, ... See full document
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Inhibition of Interferon-Mediated Antiviral Activity by Murine Gammaherpesvirus 68 Latency-Associated M2 Protein
... response. Murine gammaherpesvirus 68 ( ␥ HV68) infects a wide range of cell types and establishes latent infections in ...HV68 latency-associated M2 protein has a cell-type-dependent ... See full document
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CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68
... T cells, but not Abs, mediate the control of acute viral replication in the lungs (14, ...During latency, CD4 ⫹ and CD8 ⫹ T cells and neutralizing Abs all significantly contribute to the surveil- ... See full document
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CD40 Engagement on Dendritic Cells, but Not on B or T Cells, Is Required for Long-Term Control of Murine Gammaherpesvirus 68
... When anti-CD40 was injected directly into mice, viral titers were reduced to levels similar to those in WT mice (27). How- ever, adoptive transfer of in vitro CD40-conditioned DC ap- peared to induce a slightly lower ... See full document
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Murine Gammaherpesvirus 68 Cyclin D Homologue Is Required for Efficient Reactivation from Latency
... of latency requires the absence of preformed infectious virus in an assay of high sensitivity along with the ability to reactivate virus from explanted ...ruptured cells cannot reactivate latent virus, ... See full document
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Immature and Transitional B Cells Are Latency Reservoirs for a Gammaherpesvirus
... and B) Latency ...marrow cells from 5 mice were pooled, and parallel samples of single-cell suspensions were analyzed to determine the frequencies of bone marrow cells that harbor viral ... See full document
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NF-κB p50 Plays Distinct Roles in the Establishment and Control of Murine Gammaherpesvirus 68 Latency
... B activation during ... B activation as assessed using an NF- B luciferase reporter assay (data not ... B subunits that are activated in this latently infected B-cell line, EMSAs ... See full document
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Absence of the Uracil DNA Glycosylase of Murine Gammaherpesvirus 68 Impairs Replication and Delays the Establishment of Latency In Vivo
... impacting B cell pro- cesses critical for gammaherpesvirus ...target B cells that undergo iso- type-class switching and, in some reports, upregulate the B cell specific host cytidine ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 RTA Reactivates Murine Gammaherpesvirus 68 from Latency
... dioactivity was detected with a phosphor-imaging system. Fig- ure 2B shows that transfection of S11E cells with M/RTA or H/RTA resulted in viral DNA replication and processing. Con- sistent with the Western blot ... See full document
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Identification of Closely Spaced but Distinct Transcription Initiation Sites for the Murine Gammaherpesvirus 68 Latency-Associated M2 Gene
... Murine gammaherpesvirus 68 (MHV68) infection of mice provides a tractable small-animal system for assessing viral requirements for establishment of and reactivation from ...MHV68 latency and ... See full document
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Role of CXCR3 in the Immune Response to Murine Gammaherpesvirus 68
... of murine gammaherpesvirus 68 (MHV-68) results in acute productive infection of lung alveo- lar epithelial cells and a latent infection in several cell types (7, 17, 19, ...or ... See full document
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A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
... deubiquitination regulate essential cel- lular ...and B-cell lymphomas (22), and KSHV ␥ -2 has been associated with Kaposi’s sarcoma and B-cell lymphomas ... See full document
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Complete sequence and genomic analysis of murine gammaherpesvirus 68.
... 67, 68, 76). Both CD4 and CD8 T cells are important for control of gHV68 infection (10, 26, 76), with persistent rather than latent infection seen in CD8-deficient mice (76) and progressive infection seen ... See full document
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Cytokine production in the immune response to murine gammaherpesvirus 68.
... node cells, whereas IFN- g and IL-2 induction required prior in vivo ...the cells to make IL-6 or IL-10 (Table 1), indicating that induction of these cytokines requires live or native ...of B ... See full document
5
Induction of Protective Immunity against Murine Gammaherpesvirus 68 Infection in the Absence of Viral Latency
... infected cells by using Tri-Reagent (MRC, Cincinnati, ...BHK-21 cells or spleno- cytes by using a DNeasy tissue kit (Qiagen, Valencia, CA) according to the manufacturer’s ... See full document
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Disruption of the Murine Gammaherpesvirus 68 M1 Open Reading Frame Leads to Enhanced Reactivation from Latency
... FIG. 1. Construction and verification of the M1.LacZ virus. (A) Genomic structure of wt ␥HV68, M1.LacZ, and M1.MR in the region containing the M1 ORF. In M1.LacZ, the M1 ORF was disrupted through targeted excision of bp ... See full document
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Disruption of the M2 Gene of Murine Gammaherpesvirus 68 Alters Splenic Latency following Intranasal, but Not Intraperitoneal, Inoculation
... with murine gammaherpesvirus 68 ( ␥ HV68; also referred to as MHV68) provides a tractable small-animal model with which to address the requirements for the establishment and maintenance of ... See full document
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